Suppressive effect of low-level laser therapy on tracheal hyperresponsiveness and lung inflammation in rat subjected to intestinal ischemia and reperfusion

Lima, Flávia Mafra de; Vitoretti, Luana Beatriz; Coelho, Fernando Rodrigues; Albertini, Regiane; Breithaupt‐Faloppa, Ana Cristina; Lima, Wothan Tavares de; Aimbire, Flávio

doi:10.1007/s10103-012-1088-1

Cited by 41 publications

(23 citation statements)

References 34 publications

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“…Other experimental and clinical investigations also reported the positive effects of PBM on acute and chronic pulmonary inflammation, and acute pulmonary inflammation induced by intestinal ischemic-reperfusion [22][23][24]. Also, it has been observed that PBM may be useful for decreasing pulmonary fibrosis [25].…”

Section: Effect Of Pbm On Lung Inflammationmentioning

confidence: 90%

Photobiomodulation therapy as a high potential treatment modality for COVID-19

2020

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COVID-19 is now a worldwide concern, causing an unprecedented pandemic. The infected cases show different symptoms based on the severity of the disease. In asymptomatic and non-severe symptomatic cases, the host immune system can successfully eliminate the virus and its effects. In severe cases, however, immune system impairment causes cytokine release syndrome which eventually leads to acute respiratory distress syndrome (ARDS). In recent years, photobiomodulation (PBM) has shown promising results in reducing acute pulmonary inflammation. Considering the high potential impact of PBM on immune responses, we hypothesized that using PBM could be an effective treatment modality for ARDS management in COVID-19 patients.

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Section: Effect Of Pbm On Lung Inflammationmentioning

confidence: 90%

Photobiomodulation therapy as a high potential treatment modality for COVID-19

2020

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“…They also studied a different model of ALI caused by intestinal ischemia and reperfusion (I/R), that produces an analogue of acute respiratory distress syndrome (ARDS) [78]. Rats were subjected to superior mesenteric artery occlusion (45 min) and received PBM (660 nm, 7.5 J/cm 2 ) carried out by irradiating the rats on the skin over the right upper bronchus for 15 and 30 min, and rats were euthanized 30 min, 2, or 4 h later.…”

Section: Effects Of Pbm On Inflammation In Animal Models Of Diseasementioning

confidence: 99%

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

2017

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Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis. There is a pronounced biphasic dose response whereby low levels of light have stimulating effects, while high levels of light have inhibitory effects. It has been found that PBM can produce ROS in normal cells, but when used in oxidatively stressed cells or in animal models of disease, ROS levels are lowered. PBM is able to up-regulate anti-oxidant defenses and reduce oxidative stress. It was shown that PBM can activate NF-kB in normal quiescent cells, however in activated inflammatory cells, inflammatory markers were decreased. One of the most reproducible effects of PBM is an overall reduction in inflammation, which is particularly important for disorders of the joints, traumatic injuries, lung disorders, and in the brain. PBM has been shown to reduce markers of M1 phenotype in activated macrophages. Many reports have shown reductions in reactive nitrogen species and prostaglandins in various animal models. PBM can reduce inflammation in the brain, abdominal fat, wounds, lungs, spinal cord.

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“…LLLT can also accelerate cellular metabolic processes and increase synthesis of ATP [8] with an anti-inflammatory effect (release of inflammatory mediators, stimulation of microcirculation, absorption of exudates, and interference in the synthesis of prostaglandins) [12,13]. Research corroborates the influence of LLLT in relation to the recruitment of muscle fibers and the torque peak, in addition to delaying development of muscle fatigue, which contributes to a greater musculoskeletal performance [6,[14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 69%

Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients

et al. 2016

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A cerebrovascular accident (CVA) may affect basic motor functions, including spasticity that may be present in the upper extremity and/or the lower extremity, post-stroke. Spasticity causes pain, muscle force reduction, and decreases the time to onset of muscle fatigue. Several therapeutic resources have been employed to treat CVA to promote functional recovery. The clinical use of low-level laser therapy (LLLT) for rehabilitation of muscular disorders has provided better muscle responses. Thus, the aim of this study was to evaluate the effect of the application of LLLT in spastic muscles in patients with spasticity post-CVA. A double-blind clinical trial was conducted with 15 volunteer stroke patients who presented with post-stroke spasticity. Both males and females were treated; the average age was 51.5 ± 11.8 years old; the participants entered the study ranging from 11 to 48 months post-stroke onset. The patients participated in three consecutive phases (control, placebo, and real LLLT), in which all tests of isometric endurance of their hemiparetic lower limb were performed. LLLT (diode laser, 100 mW 808 nm, beam spot area 0.0314 cm(2), 127.39 J/cm(2)/point, 40 s) was applied before isometric endurance. After the real LLLT intervention, we observed significant reduction in the visual analogue scale for pain intensity (p = 0.0038), increased time to onset of muscle fatigue (p = 0.0063), and increased torque peak (p = 0.0076), but no significant change in the root mean square (RMS) value (electric signal in the motor unit during contraction, as obtained with surface electromyography). Our results suggest that the application of LLLT may contribute to increased recruitment of muscle fibers and, hence, to increase the onset time of the spastic muscle fatigue, reducing pain intensity in stroke patients with spasticity, as has been observed in healthy subjects and athletes.

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Suppressive effect of low-level laser therapy on tracheal hyperresponsiveness and lung inflammation in rat subjected to intestinal ischemia and reperfusion

Cited by 41 publications

References 34 publications

Photobiomodulation therapy as a high potential treatment modality for COVID-19

Photobiomodulation therapy as a high potential treatment modality for COVID-19

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Effects of low-level laser therapy (LLLT 808 nm) on lower limb spastic muscle activity in chronic stroke patients

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