Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs

Nosálóvá, G; Prisenžňáková, L.; Košťálová, Zuzana; Ebringerová, Anna; Hromàdková, Zdenka

doi:10.1016/j.fitote.2010.11.006

Cited by 27 publications

(9 citation statements)

References 37 publications

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“…The hypocholesterolemic effect depends on the viscosity of pectins, which correlates with the degree of esterification and influences the rate of glucose absorption. The anti-cough effect of pectin appears to be correlated with the degree of branching [ 27 ]. Pectins rich in GalA effectively chelate heavy metals and reduce the adhesion of pathogens [ 12 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: A comparative evaluation

et al. 2018

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The physicochemical characteristics and functional properties of pumpkin (Cucurbita maxima D. var. Cabello de Ángel) pectin obtained by cavitation facilitated extraction from pumpkin pulp have been evaluated and compared with commercial citrus and apple pectins. C. maxima pectin had an Mw value of 90 kDa and a high degree (72%) of esterification.The cytoprotective and antioxidant effects of citrus, apple and pumpkin pectin samples with different concentrations were studied in vitro in cell lines HT-29 (human colon adenocarcinoma) and MDCK1 (canine kidney epithelium). All pectin samples exhibited cytoprotective effect in HT-29 and MDCK1 cells after incubation with toxic concentrations of cadmium and mercury for 4 h. Pumpkin pectin increased the proliferation of cadmium-treated MDCK1 cells by 210%. The studied pectins also inhibited oxidative stress induced by 2,2′-azobis(2-methylpropionamidine) dihydrochloride (AAPH) in cell cultures, as determined by measuring the production of intracellular reactive species using dihydrochlorofluorescein diacetate (DCFH-DA). Pectin from pumpkin pomace had the highest (p < 0.05) protective effect against reactive oxygen species generation in MDCK1 cells induced by AAPH. Distinctive features of pumpkin pectin were highly branched RG-I regions, the presence of RG-II regions and the highest galacturonic acid content among the studied samples of pectins. This correlates with a considerable protective effect of C. maxima pectin against oxidative stress and cytotoxicity induced by heavy metal ions. Thus, C. maxima pectin can be considered as a source of new functional foods of agricultural origin.

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Section: Introductionmentioning

confidence: 99%

Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: A comparative evaluation

et al. 2018

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“…Biological activity studies on this isolate confirmed as well its ability to suppress experimentally elicited cough reflex in dose-dependent manner and moderate relaxation of airways smooth muscle without provoking any notable undesirable reactions. Similarly, a significant cough suppressive effect and insignificant decrease of sRaw of polysaccharide-proteins isolated from medicinal plants Cucurbita pepo and Glycyrrhiza glabra were noticed [33,34]. Unlike Sc complex the polyphenolic-polysaccharide conjugate isolated from Lythrum salicaria showed mild antitussive effect only while its bronchodilator effect was significant [21].…”

Section: Antitussive Activity Of S Canadensis Complexmentioning

confidence: 98%

Characterization and biological activity of Solidago canadensis complex

Šutovská

Capek

Kočmálová

et al. 2013

International Journal of Biological Macromolecules

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“…I ranija ispitivanja su pokazala da antitusično delovanje kiselih polisaharida raste sa sadržajem uronske kiseline u njima. Najsnažniji efekat pokazan je za mucilaginozne ramnogalakturonane [20].…”

Section: Biološka Aktivnost Polisaharida Bundeveunclassified

Medicinal potential of cucurbita polysaccharides

et al. 2014

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IZVODBundeva pored primene u ishrani ima i široku primenu u tradicionalnoj medicini brojnih zemalja. Poslednjih godina, zahvaljujući pokazanim farmakološkim efekatima, polisaharidi bundeve privlače sve više pažnje istraživača. Naime, različita ispitivanja pokazala su njihov antidijabetični, antioksidantni, hipolipidemijski, antibakterijski i antitusični efekat. Ipak, obzirom da je biološka aktivnost polisaharida bundeve pokazana uglavnom u in vitro studijama i na životinjskim modelima, kontrolisane kliničke studije su neophodne kako bi se potvrdili ovi efekti. Svrha ovog revijalnog rada je da prikaže dosadašnja dostignuća u ekstrakciji, karakterizaciji i određivanju biološke aktivnosti ove grupe jedinjenja.

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Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs

Cited by 27 publications

References 37 publications

Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: A comparative evaluation

Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: A comparative evaluation

Characterization and biological activity of Solidago canadensis complex

Medicinal potential of cucurbita polysaccharides

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