Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model

Murakami, Maki; Ota, Hiroyoshi; Sugiyama, Atsushi; Ishizone, Satoshi; Maruta, Fukuto; Akita, Noriyuki; Okimura, Yukie; Kumagai, Toshiko; Jo, Megumi; Tokuyama, Takashi

doi:10.1007/s00535-005-1570-7

Cited by 15 publications

(24 citation statements)

References 31 publications

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“…A lack of any direct correlation between anti-H. pylori IgG antibody titers and number of colonies was also reported by Murakami et al 37 Canola oil is a traditional cooking oil in many countries. The canolol concentration in crude canola oil is estimated to be 220-1,200 ppm, which could provide doses similar to that used in our study.…”

Section: Discussionmentioning

confidence: 52%

4‐Vinyl‐2,6‐dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori‐infected carcinogen‐treated Mongolian gerbils

Cao

Tsukamoto

Seki

et al. 2008

Intl Journal of Cancer

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Oxidative stress is linked to gastric carcinogenesis because of its ability to damage DNA. Here we examined antioxidative and antiinflammatory effects of 4-vinyl-2,6-dimethoxyphenol (canolol), a recently identified potent antioxidative compound obtained from crude canola oil, on Helicobacter (H.) pylori-induced gastritis and gastric carcinogenesis using a Mongolian gerbil model. The animals were allocated to H. pylori-infection alone (12 weeks) or H. pylori 1 N-methyl-N-nitrosourea (MNU) administration (52 weeks). After oral inoculation of H. pylori, they were fed for 10 and 44 weeks with or without 0.1% canolol. H. pylori-induced gastritis, 5 0 -bromo-2 0 -deoxyuridine (BrdU) labeling and scores for cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) immunohistochemistry were attenuated in the canololtreated groups. Expression of interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a), COX-2 and iNOS mRNA in the gastric mucosa, and serum 8-hydroxy-2 0 -deoxyguanosine (8-OHdG), anti-H. pylori IgG and gastrin levels were also significantly lower in canolol-treated groups. Furthermore, the incidence of gastric adenocarcinomas was markedly reduced in the H. pylori 1 MNU 1 canolol-treated group [15.0% (6/40)] compared to the control group [39.4% (13/33)] (p < 0.05). These data indicate canolol to be effective for suppressing inflammation, gastric epithelial cell proliferation and gastric carcinogenesis in H. pylori-infected Mongolian gerbils. Interestingly, the viable H. pylori count was not changed by the canolol containing diet. Thus, the data point to the level of inflammation because of H. pylori rather than the existence of the bacteria as the determining factor. Importantly, canolol appears to suppress induction of mRNAs for inflammatory cytokines. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 52%

4‐Vinyl‐2,6‐dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori‐infected carcinogen‐treated Mongolian gerbils

Cao

Tsukamoto

Seki

et al. 2008

Intl Journal of Cancer

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“…Madathawalu showed the highest beneficial effects in management of diabetes among the traditional rice varieties tested in this experiment. Murakami et al (2005) reported that rice has become an interesting candidate as a natural antibacterial agent. The present study was conducted to identify effect of agronomic practices on antimicrobial activity of rice.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and antimicrobial activities and starch digestion rate of the organically- and non-organically grown traditional rice varieties in Sri Lanka

et al. 2017

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Abstract:The study was designed to assess the total phenolic content (TPC), free radical scavenging activity, antimicrobial property and in vitro starch digestion rate of three traditional rice varieties grown organically and non-organically in Sri Lanka. The 70% ethanol extractions of rice were subjected to TPC, DPPH -free radical scavenging assays to determine antioxidant activity, and antimicrobial susceptible test against three bacteria, namely, Escherichia coli, Salmonella typhi and Staphylococcus aureus to determine antimicrobial properties. Starch digestion of cooked rice samples were evaluated under in vitro conditions. Both TPC and free radical scavenging activity was significantly higher (P<0.05) in organically produced traditional rice while the non-organically produced traditional rice samples showed a significantly higher (P<0.05) antimicrobial activity against S. typhi and S. aureus. There was no significant difference (P>0.05) in the in vitro starch digestion rate between the two groups. Though the study only considered traditional rice varieties, the results suggested that organically produced traditional rice samples performed better than those non-organically produced, with regard to the antioxidant properties such as TPC and free radical scavenging activity. The Madathawalu cultivar performed superior role in total phenolic content, free radical scavenging activity and Glycemic Index compared to that of two other traditional rice varieties, namely, Suwandel and Handiran.

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“…It has also been shown effective in combating the problem associated with gastritis by suppressing damage to the gastric mucosa by Helicobater pyroli in infected Mongolian gerbils 31 . The rice hull smoke extract has been shown to inhibit S. enterica serovar Typhimurium in vitro in a study reported by Kim et al, 39 that protected an infected mice from death. Presently our study strongly suggested the antibacterial activity of the rice varieties with an increased activity of black rice and anti-staphylococcal activity.…”

Section: Minimum Inhibitory Concentrationmentioning

confidence: 96%

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2017

IJPSR

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ABSTRACT:The present study was conducted to evaluate the antioxidant, antibacterial and nutraceutical properties of three coloured scented rice varieties grown in North Eastern region. The study for the analysis of Nutraceutical content involved more than five contents to find a significant correlation of the all the rice varieties. Antioxidant activity was measured using hydrogen peroxide and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. The antioxidant activities of the studied samples were expressed as percentage (%) of DPPH and H 2 O 2 radicals inhibition and IC 50 value. Among different extracts of crude rice, methanolic extract of the black rice showed highest antioxidant activity compared to the aqueous extract of the other two varieties each for DPPH (89.29±0.139) as well H 2 O 2 (80.97±0.091) with an IC 50 value of 40 µg/ml and 42.6µg/ml respectively. Also the result of MIC against the tested staphylococcus strain was notably found to be effective with a significant value of 119 µg/ml for black rice taken DMSO as the positive control.

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Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model

Abstract: The rice extract was effective in suppressing inflammation and epithelial cell proliferation in the gastric mucosa in H. pylori-infected Mongolian gerbils. The rice extract has potential to exhibit a protective effect on H. pylori-related gastric mucosal diseases.

Cited by 15 publications

References 31 publications

4‐Vinyl‐2,6‐dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori‐infected carcinogen‐treated Mongolian gerbils

4‐Vinyl‐2,6‐dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori‐infected carcinogen‐treated Mongolian gerbils

Antioxidant and antimicrobial activities and starch digestion rate of the organically- and non-organically grown traditional rice varieties in Sri Lanka

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