Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress

Ye, She-Fang; Ichimura, Kazuya; Wakame, Koji; Ohe, Masato

doi:10.1016/j.lfs.2003.06.038

Cited by 41 publications

(28 citation statements)

References 30 publications

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“…The acetylated forms of the a-1,4-glucan type of oligosaccharides have low molecular mass (5 kDa) and are considered the main active ingredient of AHCC (2)(3)(4). AHCC has been well tolerated both as a human nutritional supplement and as a therapeutic agent (1,5).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, several studies have proven that the oral administration of AHCC has a wide variety of therapeutic effects, including anticancer effects both in animal models and in clinical trials (2,3,(6)(7)(8), prevention of the onset of diabetes induced by streptozotocin in animal models (9), prevention of liver injury produced by CCl 4 in mice (10), and improvement of the immune response (7,11,12). The anticancer activity of AHCC has been ascribed to its immunomodulatory and antioxidant properties (4,7,13).…”

Section: Introductionmentioning

confidence: 99%

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Active Hexose Correlated Compound Acts as a Prebiotic and Is Antiinflammatory in Rats with Hapten-Induced Colitis

Daddaoua

Martinez-Plata

López-Posadas

et al. 2007

The Journal of Nutrition

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Active hexose correlated compound (AHCC) is a product prepared from the mycelium of edible Basidiomycete fungi that contains oligosaccharides. Here we have studied the antiinflammatory effect of AHCC in the trinitrobenzenesulfonic acid (TNBS) model of colitis in rats. Rats received AHCC (100 or 500 mg/kg) daily starting 2 d before (pretreatment) colitis induction and were killed 6 d after the TNBS challenge. The status of the rats was assessed by morphological and biochemical methods. The effect of AHCC on the colonic microflora was also assessed by studying the bacteria profile in feces by standard culture techniques. AHCC administration attenuated colonic inflammation, improving rat weight, food intake, damage score, extension of necrosis, colonic weight, colonic weight-to-length ratio, myeloperoxidase and alkaline phosphatase activities, glutathione concentration, and the expression of proinflammatory cytokines and chemokines (IL-1b, IL-1 receptor antagonist, TNF, and monocyte chemoattractant protein-1) and of mucins 2-4 and trefoil factor 3. The magnitude of the antiinflammatory effect of AHCC was similar to that of sulfasalazine (200 mg/kg). The study of colonic microflora indicated that rats treated with AHCC had higher aerobic and lactic acid bacteria counts as well as higher bifidobacteria counts, whereas clostridia were reduced when compared with the TNBS group. Therefore, our results indicate that AHCC is antiinflammatory and could be useful as a prebiotic to design functional foods for inflammatory bowel disease patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Active Hexose Correlated Compound Acts as a Prebiotic and Is Antiinflammatory in Rats with Hapten-Induced Colitis

Daddaoua

Martinez-Plata

López-Posadas

et al. 2007

The Journal of Nutrition

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“…Chemical analysis has shown that ϳ74% of AHCC is oligosaccharides and ϳ20% is of the ␣-1, 4-glucan type. The acetylated forms of the last group are oligosaccharides with low molecular mass (5 kDa) and are believed to be the molecules responsible for the biological activities of AHCC (27,28,51). AHCC has been shown to have an enhancing effect on the immune system of humans (27) and rodents (10,28,47), including an increase of natural killer cell activity (25) and IL-12 production (49,50).…”

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confidence: 99%

Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions

Avilés¹,

Belay²,

Vance³

et al. 2004

Journal of Applied Physiology

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Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 97: 1437-1444. First published June 11, 2004 10.1152 10. /japplphysiol.00259.2004 unloading is a ground-based model that simulates some of the aspects of spaceflight conditions, including lack of load bearing on hindlimbs and a fluid shift to the head. It has been shown that treatment with active hexose correlated compound (AHCC) restores resistance to infection in mice maintained under hindlimb-unloading conditions. The present study was designed to clarify the mechanisms by which AHCC enhances resistance to infection in this model. We hypothesized that oral administration of AHCC will enhance the function of the immune system, which could lead to the increased resistance to infection observed in this model. AHCC or the excipient was orally administered to mice, and the function of the immune system was assessed in spleen and peritoneal cells isolated from those groups. The results of the present study showed that administration of AHCC for 1 wk before and throughout the second day of the hindlimb-unloading period enhanced the function of the immune system assessed by spleen cell proliferation and cytokine production in spleens and nitric oxide and cytokine production in peritoneal cells. These findings suggest that AHCC can be used as a potent immunoenhancer, especially in cases in which the immune system is suppressed by any condition, including diseases such as human immunodeficiency virus infection and cancer.antiorthostatic; suspension; stress; mitogens; natural supplement; rodents ONE OF THE MAJOR LIMITATIONS to studying human physiology during and after spaceflight has been the relative infrequency of opportunities and the cost of spaceflight missions. As a result, research in this area has been conducted by using ground-based models (1). Hindlimb unloading of rodents is a ground-based model that has been used successfully to reproduce many of the effects of spaceflight on the physiology of the host (1). Exposure to hindlimb-unloading conditions induces muscle and bone loss and a fluid shift to the head, which are similar to changes induced in that area by spaceflight (20,(33)(34)(35)(36). The immune system is one of the important regulatory mechanisms affected by spaceflight (15, 23, 26, 40 -44, 46) and has been shown to be dramatically affected in groundbased models (14,24,29,30,45).Numerous substances have been used to revitalize the immune response of hosts with impaired function of the immune system (21, 27). Many of them are natural compounds that have proven to be nontoxic for humans and with great potential for anticancer activity (9, 31, 39, 48). Active hexose correlated compound (AHCC), an extract prepared from cocultured mycelia of several species of Basidiomycete mushrooms, has received special attention in the past few years (21). AHCC is commercially used as a nutritional supplement and contain a mixture of polysaccharides, amino acids, and mine...

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“…Active Hexose Correlated Compound (AHCC), extracted from several species of Basidiomycetes mushrooms, is a mixture of carbohydrates including oligosaccharides, amino acids, lipids, and minerals derived from fungi (11). The active ingredients of AHCC are a-glucan, acetylated a-glucan, and b-glucan of polysaccharides (12).…”

mentioning

confidence: 99%

“…The active ingredients of AHCC are a-glucan, acetylated a-glucan, and b-glucan of polysaccharides (12). It has been suggested that AHCC has anti-oxidative (11), anti-inflammatory (12,13) and immunostimulatory effects (14,15) as well as hepatoprotective properties in vitro (16,17) and in vivo (12).…”

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confidence: 99%

Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

Kim

2014

J Nutr Sci Vitaminol

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SummaryTo investigate the effects of Active Hexose Correlated Compound (AHCC) supplementation and the mechanism action of AHCC in patients with alcohol-induced mildly elevated liver enzyme levels, participants were randomly allocated to the placebo, 1 g AHCC, or 3 g AHCC group and took the supplement for 12 wk. Subjects visited the hospital for clinical and biochemical measurements, for examination of adverse events, to return unused supplements, and to obtain their next supplements. Biochemical tests including liver enzymes, a questionnaire survey, and anthropometric measurements were collected at baseline and every 4 wk thereafter. Adherence and adverse events were evaluated. After 12 wk of supplementation, the percentage change in alanine aminotransferase (ALT) level was significantly different between the placebo (4.02659.07%) and both AHCC groups (1 g AHCC: 223.89620.59%, 3 g AHCC: 224.09630.73%) (p50.04). Serum levels of tumor necrosis factor-a (p,0.05) and interleukin-1b (p,0.01) were significantly lower, while those of adiponectin were higher in both AHCC groups than in the placebo group (p,0.01). AHCC supplementation for 12 wk may improve the levels of liver enzymes and circulating pro-inflammatory and anti-inflammatory cytokines in patients with alcohol-induced liver enzyme elevation with mildly elevated liver enzyme levels.

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Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress

Cited by 41 publications

References 30 publications

Active Hexose Correlated Compound Acts as a Prebiotic and Is Antiinflammatory in Rats with Hapten-Induced Colitis

Active Hexose Correlated Compound Acts as a Prebiotic and Is Antiinflammatory in Rats with Hapten-Induced Colitis

Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions

Effect of Active Hexose Correlated Compound (AHCC) in Alcohol-Induced Liver Enzyme Elevation

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