Supraglottoplasty outcomes in children with Down syndrome

Cockerill, Cara C.; Frisch, Christopher D.; Rein, Sarah; Orvidas, Laura J.

doi:10.1016/j.ijporl.2016.05.022

Cited by 20 publications

(16 citation statements)

References 18 publications

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“…Eleven articles describe specific cohorts with DS and an additional diagnosis which may give insight into risk factors. Specifically, pneumonia and respiratory infections were described in those: undergoing treatment for DS-AML (Hassler et al, 2016;Kudo et al, 2007;Lehrnbecher et al, 2004), with congenital heart disease (Bush et al, 2018;Layangool et al, 2014;Thompson, McElhinney, Jue, & Hodge, 1999), and those who had undergone orthopedic procedures (Boylan et al, 2016;Lerman, Emans, Hall, & Karlin, 2003;Siemionow, Hansdorfer, Janusz, & Mardjetko, 2017), intestinal surgeries (Buchin, Levy, & Schullinger, 1986;Cairo et al, 2019), or airway procedures (Cockerill, Frisch, Rein, & Orvidas, 2016;Pravit, 2014). Airway anomalies, GERD, and pulmonary hypertension were associated with recurrent pneumonia (Bush et al, 2018;Pravit, 2014;Thompson et al, 1999).…”

Section: Original Literature Reviewmentioning

confidence: 99%

Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Santoro

Chicoine

Jasien

et al. 2020

American J of Med Genetics Pt A

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Pneumonia and respiratory infections impact infants and children with Down syndrome; pneumonia is a leading cause of mortality in adults with Down syndrome. We aimed to review the literature to evaluate gaps and address key questions. A series of key questions were formulated a priori to inform the search strategy and review process; addressed prevalence, severity, etiology, risk factors, preventive methods, screening, and financial costs, potential benefits or harms of screening. Using the National Library of Medicine database, PubMed, detailed literature searches on pneumonia and respiratory infections in Down syndrome were performed. Previously identified review articles were also assessed. The quality of available evidence was then evaluated and knowledge gaps were identified. Forty‐two relevant original articles were identified which addressed at least one key question. Study details including research design, internal validity, external validity, and relevant results are presented. Pneumonia and respiratory infections are more prevalent and more severe in individuals with Down syndrome compared to healthy controls through literature review, yet there are gaps in the literature regarding the etiology of pneumonia, the infectious organism, risk factors for infection, and to guide options for prevention and screening. There is urgent need for additional research studies in Down syndrome, especially in the time of the current COVID‐19 pandemic.

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Section: Original Literature Reviewmentioning

confidence: 99%

Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Santoro

Chicoine

Jasien

et al. 2020

American J of Med Genetics Pt A

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“…Four additional studies were excluded due to lack of sufficient information [55], [86]- [88], one study was excluded due to reliance on symptom improvement rather than PSG [89], and three other studies were excluded because they employed more invasive surgeries [18], [59], [78]. [12], [83], [84].…”

Section: Surgery and Osa Outcomementioning

confidence: 99%

Obstructive Sleep Apnea in Individuals with Down Syndrome: A Meta-Analytic Literature Review

Ridore

Debbarma

Nazir

et al. 2017

JSDR

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Abstract:Objective:Individuals diagnosed with Down syndrome (DS) are predisposed to obstructive sleep apnea (OSA). The aim of this study is to assess the prevalence of OSA and factors associated with OSA in this population. Study Design:Systematic literature review and meta-analysis. Methods:Studies of DS and OSA in the English language through May 2017 were reviewed. Since parental report of symptoms has limited validity related to the diagnosis of OSA, only studies using in laboratory polysomnography to diagnose OSA were included. Results:Twenty three studies examining OSA among 1,469 people with DS were found. Among ten studies using community referred samples, 71.5% of people with DS had OSA, compared to 69.6% in referred community samples suspected of having respiratory events. There was an inverse relationship between apnea hypopnea index (AHI) cutoffs and OSA prevalence as higher cutoffs were associated with somewhat lower prevalence.Examining age groups, adults had a higher prevalence of OSA (90.0%) compared to infants (66.5%) and children between 2-21 years of age (69.9%). Oxygen desaturation and gender did not affect prevalence.Although surgery had less effect on successfully treating OSA among DS individuals compared to those without DS in prior studies, lingual tonsillectomy had the greatest effect (mean AHI decrease of 9.0). Conclusion:OSA appears to occur frequently in children and adults with DS. Untreated, OSA may contribute to health problems and premature death, highlighting the potential importance of identifying OSA among people with DS.Even after traditional surgeries (i.e., adenotonsillectomy, tonsillectomy, adenoidectomy), repeating PSG is highly recommended as residual OSA can persist

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“…34 Another study reviewed the outcomes of supraglottoplasty specifically in children with DS, and found that patients (n 5 4) had a median AHI decrease of 6.5 events/hour, although many required subsequent surgical treatment. 35 This study does have limitations that are common when using large national databases. There may be coding inaccuracies present, and patients may be erroneously included or excluded from the dataset due to possible coding errors.…”

Section: Discussionmentioning

confidence: 96%

“…A recent meta‐analysis showed that supraglottoplasty was an effective surgical option in patients with both laryngomalacia and OSA; however, the aggregated population was heterogeneous but also included children with DS . Another study reviewed the outcomes of supraglottoplasty specifically in children with DS, and found that patients (n = 4) had a median AHI decrease of 6.5 events/hour, although many required subsequent surgical treatment …”

Section: Discussionmentioning

confidence: 99%