Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system

Abstract

Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic agents. A supramolecular approach that may allow co-delivery of two drugs is described here.

Research Progress and Prospects for Polymeric Nanovesicles in Anticancer Drug Delivery

“…Host-guest nanovesicles were also used to (Li et al, 2017) simultaneously carry DOX and oxaliplatin. Within 24 h, the release of both drugs at pH 7.4 was ~10% of that at pH 5.0, and in vivo experiments with a HepG-2 tumor model confirmed the safety of this drug delivery system (Chen et al, 2020). Xiao et al developed copper-zeolitic imidazolate/carboxylated pillar six arene/methylene blue hybrid nanovesicles combining photodynamic and anticancer drug carriers.…”

Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy

“…S24 †), which agreed well with reported work. 34,35 Further support for the low toxicity inferred for CP6A came from histological analyses of brain slices, including the cerebral cortex and hippocampal region. Compared with the control group, no detectable lesions or histopathological abnormalities could be noted (Fig.…”

A biocompatible hydrogel as a template for oxidative decomposition reactions: a chemodosimetric analysis and in vitro imaging of hypochlorite

“…11–22 On the other hand, as a signalling moiety, pyrene remains as the fluorophore of choice due to its excellent photostability, high quantum yield and ability to undergo monomer to excimer transformation depending upon the microenvironment. 23–28…”