Supramolecular Organic Frameworks: Exploring Water-Soluble, Regular Nanopores for Biomedical Applications

Li, Zhan‐Ting; Yu, Shang‐Bo; Liu, Yamin; Tian, Jia; Zhang, Dan‐Wei

doi:10.1021/acs.accounts.2c00335

Cited by 45 publications

(13 citation statements)

References 50 publications

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“…Since 2013, a variety of well-defined self-assembled porous systems termed supramolecular organic frameworks (SOFs) have been constructed in water. 29,30 SOFs and HOFs are organic molecular frameworks which are discussed in this review (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Luminescent organic molecular frameworks from tetraphenylethylene-based building blocks

Wei

2023

J. Mater. Chem. C

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Section: Introductionmentioning

confidence: 99%

Luminescent organic molecular frameworks from tetraphenylethylene-based building blocks

Wei

2023

J. Mater. Chem. C

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“…Notably, in the SOF-3/PES beads, the pores were not as flat and smooth as the pure beads, indicating that SOF-3 powders were loaded and maintained their spongy-like pores. Previous studies showed that SOFs have very low surface areas but efficiently adsorb organic guests driven by hydrophobicity and/or ion-pairing electrostatic interaction . It is thus reasonable to propose that the adsorption of bilirubin by PES bead-supported SOF composites should take place through a similar mechanism.…”

Section: Resultsmentioning

confidence: 95%

“…Previous studies showed that SOFs have very low surface areas 40 but efficiently adsorb organic guests driven by hydrophobicity and/ or ion-pairing electrostatic interaction. 53 It is thus reasonable to propose that the adsorption of bilirubin by PES beadsupported SOF composites should take place through a similar mechanism. The above modeling studies showed that all four SOFs possessed a comparable or identical pore aperture or void volume.…”

Section: ■ Introductionmentioning

confidence: 99%

Supramolecular Organic Frameworks as Adsorbents for Efficient Removal of Excess Bilirubin in Hemoperfusion

Liu

Wang

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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Excess bilirubin accumulates in the bodies of patients suffering from acute liver failure (ALF) to cause much irreversible damage and bring about serious clinical symptoms such as kernicterus, hepatic coma, or even death. Hemoperfusion is a widely used method for removing bilirubin from the blood, but clinically used adsorbents have unsatisfactory adsorption capacity and kinetics. In this study, we prepared four supramolecular organic framework microcrystals SOF-1−4 via slow evaporation of their aqueous solutions under infrared light. SOF-1−4 possess good regularity and excellent stability. We demonstrate that all the four SOFs could serve as adsorbents for bilirubin with fast adsorption kinetics within 20 min and ultrahigh adsorption capacity of 609.1 mg g −1 , driven by electrostatic interaction and hydrophobicity. The superior adsorption performance of the SOFs outperformed most of the reported bilirubin adsorbents. Remarkably, SOF-3 could remove about 90% of bilirubin in the presence of 40 g L −1 BSA with a minimal loss of albumin and was thus further processed to a bead-shaped composite with a diameter of 2 mm with poly(ether sulfone) (PES). This PES-loaded SOF could efficiently adsorb bilirubin to the normal level from human plasma with an adsorption equilibrium concentration of 7.8 mg L −1 in 6 h through a dynamic hemoperfusion process. This work provides a new vitality for the development of novel bilirubin adsorbents for hemoperfusion therapy.

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“…[44] The simulated 1 : 2 host-guest structures of Guest 2 �GBox-4 4 + indicated that guest molecules can be stably located in the two host cavities via typical donor-acceptor interactions (Figures 2e, S42-S45). This 1 : 2 host-guest cyclophane motif is reminiscent of the ternary supramolecular system comprising a cucurbit-[8]uril host and two aromatic guests, [45][46] which has been extensively employed to construct various systems including artificial receptors, [47] supramolecular organic frameworks [48][49] and polymers. [50] Taking high solubility of GBox-4 4 + and convenient derivatization of the 3,3'-bipyridinium moiety into consideration, our ternary assembly motif Guest 2 �GBox-4 4 + is a promising subunit for constructing complex multicomponent systems such as mechanically interlocked molecules, molecular machines or supramolecular polymers, which will be reported elsewhere.…”

Section: Resultsmentioning

confidence: 99%

Manipulating Host‐Guest Charge Transfer of a Water‐Soluble Double‐Cavity Cyclophane for NIR‐II Photothermal Therapy

Yang

Zhang

et al. 2023

Angewandte Chemie

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Water‐soluble small organic photothermal agents (PTAs) over NIR‐II biowindow (1000–1350 nm) are highly desirable, but the rarity greatly limits their applications. Based on a water‐soluble double‐cavity cyclophane GBox‐44+, we report a class of host–guest charge transfer (CT) complexes as structurally uniform PTAs for NIR‐II photothermal therapy. As a result of its high electron‐deficiency, GBox‐44+ can bind different electron‐rich planar guests with a 1 : 2 host/guest stoichiometry to readily tune the CT absorption band that extends to the NIR‐II region. When using a diaminofluorene guest substituted with an oligoethylene glycol chain, the host–guest system realized both good biocompatibility and enhanced photothermal conversion at 1064 nm, and was then exploited as a high‐efficiency NIR‐II PTA for cancer cell and bacterial ablation. This work broadens the potential applications of host–guest cyclophane systems and provides a new access to bio‐friendly NIR‐II photoabsorbers with well‐defined structures.

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Supramolecular Organic Frameworks: Exploring Water-Soluble, Regular Nanopores for Biomedical Applications

Cited by 45 publications

References 50 publications

Luminescent organic molecular frameworks from tetraphenylethylene-based building blocks

Luminescent organic molecular frameworks from tetraphenylethylene-based building blocks

Supramolecular Organic Frameworks as Adsorbents for Efficient Removal of Excess Bilirubin in Hemoperfusion

Manipulating Host‐Guest Charge Transfer of a Water‐Soluble Double‐Cavity Cyclophane for NIR‐II Photothermal Therapy

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