Supramolecular organization and enzyme-effector properties of double coordination salts with malatostannate/germanate(IV) anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-phenanthroline cations

Afanasenko, Eleonora; Сейфулліна, І. Й.; Марцинко, Е. Э.; Dyakonenko, Viktoriya V.; Shishkina, Svitlana V.; Гудзенко, О.В.; Varbanets, L.D.

doi:10.1016/j.molstruc.2022.133996

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2022.133996

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Supramolecular organization and enzyme-effector properties of double coordination salts with malatostannate/germanate(IV) anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-phenanthroline cations

Eleonora Afanasenko

І. Й. Сейфулліна

Е. Э. Марцинко

et al.

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Cited by 4 publications

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“…It is known that various synthetic eff ectors are able to increase the activity of enzymes and the effi ciency of hydrolysis of substrates. Previously [7][8][9], we have shown that a signifi cant part of the coordination compounds of various metals act as eff ectors of the activity of α-L-rhamnosidases. Th erefore, the purpose of this study was to investigate the effect of a number of newly synthesized coordination compounds of Ge(IV) with Ba(II) (Co(II), Ni(II), Cu(II), Zn(II)) and gluconic acid on the activity of α-L-rhamnosidases from Penicillium tardum and Eupenicillium erubescens.…”

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confidence: 97%

“…Analysis of the nature of the interaction of complexes with enzymes allows us to conclude that promising eff ectors among coordination compounds of biologically active metals and ligands are compounds whose structural organization ensures the synergism of the action of all components. Also, we have shown [7][8][9] that various germanium complexes with bioligands can be recommended for a targeted search of α-L-rhamnosidase eff ectors. (М=Co, n=4) stimulates the activity of P. tardum α-L-rhamnosidase by only 39%.…”

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confidence: 99%

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Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

Gudzenko,

Borzova,

Varbanets

et al. 2023

Mikrobiol. Z.

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α-L-Rhamnosidase (α-L-rhamnoside-rhamnohydrolase EC 3.2.1.40) showing specificity for terminal α-1,2-, α-1,4- and α-1,6-linked rhamnose residues, which often present in glycoconjugates and synthetic glycosides, can be successfully used in biotechnology for the hydrolysis of rhamnopyranoside residues present in some bioflavonoids, glycoproteins, glycolipids, and other glycoconjugates. Previously, we have shown that a significant part of the coordination compounds of various metals act as effectors of the activity of α-L-rhamnosidases. The aim of this investigation was to study the effect of a number of newly synthesized coordination compounds of Ge(IV) and Ba(II), (Co(II), Ni(II), Cu(II), Zn(II) with gluconic acid on the activity of Penicillium tardum and Eupenicillium erubescens α-L-rhamnosidases. Methods. The objects of the study were Penicillium tardum and Eupenicillium erubescens α-L-rhamnosidases. α-L-Rhamnosidase activity was determined by the Davis method using naringin as a substrate. Coordination compounds Ge(IV) and Ba(II), Co(II), Ni(II), Cu(II) ,and Zn(II) with gluconic acid were used as enzyme activity modifiers. The synthesized complexes correspond to the formulas [М(H2O)6][Ge2(OH)2(C6H8O7)2]·nH2O (М = Ba(1), n=2; Co(2), n=4; Ni(3), n=4; Cu(4), n=4; Zn(5), n=3). Results. The effect of coordination compounds 1-(5) on the activity of α-L-rhamnosidase in two strains of Penicillium tardum and Eupenicillium erubescens was studied depending on the exposure time and concentration of the effector. It was shown that compound (3) at a concentration of 0.01% (1 h incubation) led to a slight (by 5%) increase in the activity of P. tardum α-L-rhamnosidase. Compound 1 at a concentration of 0.1% led to a decrease in the activity of P. tardum α-L-rhamnosidase by 29% during the first hour, and after 24 h of incubation, a decrease in the inhibitory effect to 15% was noted. Compounds 2 and (4) activated the enzyme by 9-39% at 1h exposure. At a concentration of 0.1% and exposure time of 1 h, compound 1 increased the activity of E. erubescens α-L-rhamnosidase by 80%, while at a decrease in concentration to 0.01%, the activity increased only by 29%. In general, it should be noted that in most cases, an increase in the duration of incubation up to 24 h led to a decrease in the level of activation (or inhibition) and a return to the control values of enzyme activity. Conclusions. The variety of effects of metal coordination compounds on the activity of enzymes, depending on the nature of the cation and the origin of the enzyme, has been established. The involvement of Ba(II) had the greatest activating effect on the activity of E. erubescens α-L-rhamnosidase compared to other metals.

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confidence: 99%

Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

Gudzenko,

Borzova,

Varbanets

et al. 2023

Mikrobiol. Z.

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The crystal structure of catena-poly[aqua-nitrato-κ³ O,O:O′′-(1,10-phenanthroline-κ² N,N ^′)sodium(I)], C₂₄H₁₈N₆O₇Na₂

Zeng-Bing,

Shu-Cheng,

Bing-Qi

et al. 2024

Zeitschrift Für Kristallographie - New Crystal Structures

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The influence of coordination compounds with malatogermanate/stannate anions and 1,10-phenanthroline cations of 3D metals on α-L-rhamnosidase activity of Penicillium tardum, Penicillium restrictum and Eupenicillium erubescens

Gudzenko,

Borzova,

Varbanets

et al. 2023

Ukr.Biochem.J.

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The search for effectors capable of influencing the catalytic activity of enzymes is an important area of modern enzymology. The aim of the study was to investigate the ability of 6 coordination compounds with malatogermanate/stannate anions and 1,10-phenanthroline cations of 3d metals to modify α-L-rhamnosidase activity of Penicillium tardum, Penicillium restrictum and Eupenicillium еrubescens strains. α-L-Rhamnosidase activity was determined by the Davis method using naringin as a substrate. It was demonstrated that [Ni(phen)3]2[{Sn(HMal)2(Mal)}Cl]•14H2O) in 0.1% concentration had the most pronounced activating effect on α-L-rhamnosidase activity of all strains studied. Noncompetitive inhibition of α-L-rhamnosidase in E. еrubescens by [Cu(phen)3]2[{Sn(HMal)2(Mal)}Cl]•10H2O was shown. The obtained results expand the idea of glycosidases possible activators and inhibitors and indicate the perspective of their use in modern biotechnological processes. Keywords: d-metals, double coordination compounds, Eupenicillium erubescens, germanium(IV), Penicillium restrictum, Penicillium tardum, stannum(IV), α-L-rhamnosidase

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Supramolecular organization and enzyme-effector properties of double coordination salts with malatostannate/germanate(IV) anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-phenanthroline cations

Cited by 4 publications

References 27 publications

Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

The crystal structure of catena-poly[aqua-nitrato-κ³ O,O:O′′-(1,10-phenanthroline-κ² N,N ^′)sodium(I)], C₂₄H₁₈N₆O₇Na₂

The influence of coordination compounds with malatogermanate/stannate anions and 1,10-phenanthroline cations of 3D metals on α-L-rhamnosidase activity of Penicillium tardum, Penicillium restrictum and Eupenicillium erubescens

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Supramolecular organization and enzyme-effector properties of double coordination salts with malatostannate/germanate(IV) anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-phenanthroline cations

Cited by 4 publications

References 27 publications

Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

Germanium (IV) Complexes with Gluconic Acid as Effectors of Penicillium tardum and Eupenicillium erubescens α-L-Rhamnosidases

The crystal structure of catena-poly[aqua-nitrato-κ3 O,O:O′′-(1,10-phenanthroline-κ2 N,N ′)sodium(I)], C24H18N6O7Na2

The influence of coordination compounds with malatogermanate/stannate anions and 1,10-phenanthroline cations of 3D metals on α-L-rhamnosidase activity of Penicillium tardum, Penicillium restrictum and Eupenicillium erubescens

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The crystal structure of catena-poly[aqua-nitrato-κ³ O,O:O′′-(1,10-phenanthroline-κ² N,N ^′)sodium(I)], C₂₄H₁₈N₆O₇Na₂