Supramolecular Peptide Amphiphile Vesicles through Host–Guest Complexation

Jiao, Dezhi; Geng, Jin; Loh, Xian Jun; Das, Debapratim; Lee, Tung‐Chun; Scherman, Oren A.

doi:10.1002/anie.201202947

Cited by 197 publications

(144 citation statements)

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“…261 The strategy was further used to prepare supramolecular peptide amphiphiles that self-assemble into stimuli-responsive vesicles. 262,263 The preparation of supramolecular polymers using CB [8] connections has been hampered by its low solubility (<1 mM) in water and the inability to increase the monomer concentration past the critical concentration which has resulted in the predominant formation of dimers and other small cyclic oligomers. 264 Zhang and coworkers have reported the ,dimer in dimer' strategy to overcome this limitation.…”

mentioning

confidence: 99%

Controlling supramolecular polymerization through multicomponent self‐assembly

Besenius

2016

J. Polym. Sci. Part A: Polym. Chem.

128

102

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The self-assembly into supramolecular polymers is a process driven by reversible non-covalent interactions between monomers, and gives access to materials applications incorporating mechanical, biological, optical or electronic functionalities. Compared to the achievements in precision polymer synthesis via living and controlled covalent polymerization processes, supramolecular chemists have only just learned how to developed strategies that allow similar control over polymer length, (co)monomer sequence and morphology (random, alternating or blocked ordering). This highlight article discusses the unique opportunities that arise when coassembling multicomponent supramolecular polymers, and focusses on four strategies in order to control the polymer architecture, size, stability and its stimuli-responsive properties: (1) endcapping of supramolecular polymers, (2) biomimetic templated polymerization, (3) controlled selectivity and reactivity in supramolecular copolymerization, and (4) living supramolecular polymerization. In contrast to the traditional focus on equilibrium systems, our emphasis is also on the manipulation of selfassembly kinetics of synthetic supramolecular systems. V C 2016

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confidence: 99%

Controlling supramolecular polymerization through multicomponent self‐assembly

Besenius

2016

J. Polym. Sci. Part A: Polym. Chem.

128

102

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“…Liposome formulations have progressed and they are still improving [2,3], and currently they represent an innovative area of great scientific interest due to their wide variety of potential applications in biomedicine. Liposomes protect encapsulated molecules against degradation and can be designed to deliver them into specific target cells [4].…”

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confidence: 99%

Liposome-Based Immunotherapy Against Autoimmune Diseases: Therapeutic Effect on Multiple Sclerosis

Pujol‐Autonell

Mansilla

Rodríguez-Fernández

et al. 2017

Nanomedicine (Lond.)

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Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. Materials & methods: Phosphatidylserine-rich liposomes were loaded with disease-specific autoantigen. Therapeutic capability of liposomes was assessed in vitro and in vivo. Results: Liposomes induced a tolerogenic phenotype in dendritic cells, and arrested autoimmunity, thus decreasing the incidence, delaying the onset and reducing the severity of experimental disease, correlating with an increase in a probably regulatory CD25+ FoxP3- CD4+ T-cell subset. Conclusion: This is the first work that confirms phosphatidylserine-liposomes as a powerful tool to arrest multiple sclerosis, demonstrating its relevance for clinical application.

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“…In addition to self-assembled vesicles [14][15][16][17][18] or synthetic polymersomes 19 , the majority of reported structures rely on templating by exo [20][21][22] , meso 23,24 , endo 25 or exo-endo 26,27 methods. These approaches are experimentally laborious, with the use of a solid template requiring subsequent etching under relatively harsh conditions to obtain a hollow structure, lowering encapsulation and loading efficiencies.…”

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confidence: 99%

Interfacial assembly of dendritic microcapsules with host–guest chemistry

et al. 2014

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The self-assembly of nanoscale materials to form hierarchically ordered structures promises new opportunities in drug delivery, as well as magnetic materials and devices. Herein, we report a simple means to promote the self-assembly of two polymers with functional groups at a water-chloroform interface using microfluidic technology. Two polymeric layers can be assembled and disassembled at the droplet interface using the efficiency of cucurbit[8]uril (CB[8]) host-guest supramolecular chemistry. The microcapsules produced are extremely monodisperse in size and can encapsulate target molecules in a robust, well-defined manner. In addition, we exploit a dendritic copolymer architecture to trap a small hydrophilic molecule in the microcapsule skin as cargo. This demonstrates not only the ability to encapsulate small molecules but also the ability to orthogonally store both hydrophilic and hydrophobic cargos within a single microcapsule. The interfacially assembled supramolecular microcapsules can benefit from the diversity of polymeric materials, allowing for fine control over the microcapsule properties.

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Supramolecular Peptide Amphiphile Vesicles through Host–Guest Complexation

Cited by 197 publications

References 50 publications

Controlling supramolecular polymerization through multicomponent self‐assembly

Controlling supramolecular polymerization through multicomponent self‐assembly

Liposome-Based Immunotherapy Against Autoimmune Diseases: Therapeutic Effect on Multiple Sclerosis

Interfacial assembly of dendritic microcapsules with host–guest chemistry

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