Supramolecular polyelectrolyte complex (SPEC): pH dependent phase transition and exploitation of its carrier properties

Abstract

A supramolecular poly-electrolyte complex (SPEC) comprising poly-electrolyte acrylic acid with supramolecularly complexed guanidium is reported. This complex shows pH responsive phase transitions, which are described and characterized using microscopy, spectroscopy, density functional theory studies and Monte Carlo simulations. The phase behaviour of the SPEC is exploited by loading a dye like perylene and a drug, viz., doxorubicin, and their pH dependent controlled release is demonstrated, owing to the pH dependent phase change of the SPEC.

Preparation of chitosan and carboxymethylcellulose‐based polyelectrolyte complex hydrogel via SD‐A‐SGT method and its adsorption of anionic and cationic dye

“…Molecular dynamic simulation is a very powerful toolbox in modern molecular modeling, and enables us to follow and understand structures and dynamics with extreme detail‐literally on scales where motion of individual atoms can be tracked . It has been widely used to study the formation mechanism and microstructure of PECHs prepared under different conditions . Molecular dynamics simulation is an effective method to predict the formation process and the microstructure of PECHs prepared by SD‐A‐SGT.…”

“…[15] It has been widely used to study the formation mechanism and microstructure of PECHs prepared under different conditions. [16] Molecular dynamics simulation is an effective method to predict the formation process and the microstructure of PECHs prepared by SD-A-SGT. However, because the chain structure of natural polyelectrolyte is influenced by the pH and ion strength of solutions, the flexibility and conformation of polysaccharide vary with the solvent acidity, leading to the cumbersome calculation.…”

Peptide-Based Polymer–Polyoxometalate Supramolecular Structure with a Differed Antimicrobial Mechanism

“…Supramolecular self-assembly-driven electrostatic interaction plays a pivotal role in several biological events by creating hierarchical structural features with diverse functionalities. − By exploiting supramolecular interaction, it is possible to make a plethora of macromolecular hybrids having distinct bioactive properties along with an enhanced biocompatible feature. , Thus, utilization of supramolecular self-assembly becomes an attractive way to modulate microbial-killing feature. The tuning of bacterial-killing ability by reversible supramolecular assembly–disassembly processes has been recently explored by several groups. ,− For example, Diacon et al have reported a hybrid sandwich material consists of polymer colloids, silver nanoparticles, and multiwall carbon nanotubes with potential bioactivity .…”

Poly(acrylic acid) interpolymer complexes

“…Hydrogen bonding is one of the most important factors to consider in the self-assembly of both natural and synthetic macromolecules 1 . However, even a comparatively simple polymer such as poly(acrylic acid) (PAA), a weak polyelectrolyte, experiences a range of other interacting forces (such as hydrophobic and ion-dipole interactions), which affect complex stability and can drive phase transitions [2][3][4] .…”

“…Complexation with a variety of water soluble polymers were studied. Many of these systems have previously been studied, and besides pH IPC binding can vary depending on bothtemperature, concentration, molar mass and ionic strength [2][3][4][5][6][7][8] . For this study we have measured dilute solutions (0.1-0.5 mg ml -1 ), at low ionic strength at room temperature (18-22 ˚C) to ensure results are comparable.…”