Supramolecular Polymeric Materials Containing Cyclodextrins

Nakahata, Masaki; Takashima, Yoshinori; Harada, Akira

doi:10.1248/cpb.c16-00778

Cited by 30 publications

(15 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A hydrogel incorporating both CD and ferrocene (FC) units expands on oxidation with Ce 4+ salts, as the resulting cationic FC + can longer bind in the CD cavity (Figure ). The movement of this artificial muscle is reversible, as shown with a weight attached to a gel strip, which moves up and down in a redox circle . A powerful movement was demonstrated with chitosan hydrogel filled in a small tube with pores allowing contact with the surrounding solution (Figure ) .…”

Section: Chemomechanical Polymersmentioning

confidence: 94%

Logic‐Gate Functions in Chemomechanical Materials

Schneider

2017

ChemPhysChem

View full text Add to dashboard Cite

Chemomechanical polymers that change their shape or volume on stimulation by multiple external chemical signals, particularly on the basis of selective molecular recognition, are discussed. Several examples illustrate how such materials, usually in the form of hydrogels, can be used for the design of chemically triggered valves or artificial muscles and applied, for example, in self-healing materials or drug delivery. The most attractive feature of such materials is that they can combine sensor and actuator within single units, from nano- to macrosize. Simultaneous action of a cofactor allows selective response in the sense of AND logic gates by, for example, amino acids and peptides, which without the presence of a second effector do not induce any changes.

show abstract

Section: Chemomechanical Polymersmentioning

confidence: 94%

Logic‐Gate Functions in Chemomechanical Materials

Schneider

2017

ChemPhysChem

View full text Add to dashboard Cite

show abstract

“…6g). Recently, advanced gels such as topological gels based on polyrotaxane 29,30) and supramolecular gels based on crosslinking through host-guest interactions 19,[164][165][166][167][168][169][170][171][172][173] have become a trend in material sciences. However, application of these materials in pharmaceutical sciences is limited so far.…”

Section: Cyclodextrin-based Supramolecular Drug Deliverymentioning

confidence: 99%

“…CyDs and their derivatives are widely used as pharmaceutical excipients to improve pharmaceutical properties such as stability, solubility, bioavailability, and taste of drugs. 13,14,16) Notably, CyDs have been used as building blocks of supermolecules, [17][18][19][20] as well as crown ethers, 21) cucurbituril, 22) pillar[n] arenes, 23,24) cryptand, 25) and calixarene. 26) Therefore CyDs can play the role of mediators between supramolecular chemistry and pharmaceutical sciences.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules

et al. 2018

View full text Add to dashboard Cite

Supramolecular chemistry is an extremely useful and important domain for understanding pharmaceutical sciences because various physiological reactions and drug activities are based on supramolecular chemistry. However, it is not a major domain in the pharmaceutical field. In this review, we propose a new concept in pharmaceutical sciences termed "supramolecular pharmaceutical sciences," which combines pharmaceutical sciences and supramolecular chemistry. This concept could be useful for developing new ideas, methods, hypotheses, strategies, materials, and mechanisms in pharmaceutical sciences. Herein, we focus on cyclodextrin (CyD)-based supermolecules, because CyDs have been used not only as pharmaceutical excipients or active pharmaceutical ingredients but also as components of supermolecules.

show abstract

“…[99][100][101][102][103][104][105] These pioneering works were followed by a variety of studies in which the movable junction point played a crucial role. [106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122] In these reports on RCPs, the number of wheel components utilized for the crosslink points and their movable length or range on the axle …”

Section: Topology-transformable Polymersmentioning

confidence: 99%

Topology-transformable polymers: linear–branched polymer structural transformation via the mechanical linking of polymer chains

Takata

Aoki

2017

Polym J

View full text Add to dashboard Cite

In this review article, we discuss the synthesis and dynamic nature of macromolecular systems that have mechanically linked polymer chains capable of undergoing a topology transformation driven by a rotaxane molecular switch. The rotaxane linking of polymer chains plays a crucial role in these systems. A linear polymer possessing a crown ether/sec-ammonium salt-type [1] rotaxane moiety at the axle chain terminal was prepared via the rotaxane linking of a single polymer chain. A linear-cyclic polymer topology transformation was achieved via the movement of the wheel component from one end to the other end of the axle component using the rotaxane macromolecular switch function. The successful synthesis of a macromolecular [2]rotaxane (M2R) possessing a single polymer axle and one crown ether wheel led to a variety of unique applications, such as the development of topology-transformable polymers and the synthesis of rotaxane crosslinked polymers (RCPs). The introduction of a polymer chain to the wheel component of M2R (rotaxane linking of two polymer chains) produced a rotaxane-linked AB block copolymer that transformed its topology from linear to branched. Furthermore, a rotaxane-linked three-component polymer and an ABC triblock copolymer were synthesized and transformed to the corresponding 3-arm star (co)polymers, and the transformation was confirmed by measuring the hydrodynamic volume change. The structural transformation of 4-arm and 6-arm star polymers was also accomplished using the dynamic mobility of a similar rotaxane. As a useful application, M2R-based vinylic crosslinkers (RCs) were prepared and applied to the synthesis of RCPs, whereby the addition of RCs into radical polymerization systems of vinyl monomers afforded polymers with excellent toughness by enhancing both of tradeoff properties that cannot be achieved using typical covalent crosslinkers.

show abstract

Supramolecular Polymeric Materials Containing Cyclodextrins

Cited by 30 publications

References 62 publications

Logic‐Gate Functions in Chemomechanical Materials

Logic‐Gate Functions in Chemomechanical Materials

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules

Topology-transformable polymers: linear–branched polymer structural transformation via the mechanical linking of polymer chains

Contact Info

Product

Resources

About