Supramolecular solvent-based microextraction probe for fast detection of bisphenols by ambient mass spectrometry

Dueñas-Mas, María Jesús; Ballesteros‐Gómez, Ana; Rubio, Soledad

doi:10.1016/j.chemosphere.2022.133719

Cited by 15 publications

(4 citation statements)

References 39 publications

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“…On the basis of our previous study (Dueñas-Mas et al, 2022), SUPRASs were made up from solutions containing the amphiphile (either 1-hexanol or 1-decanol, 5% v/v), ethanol (10%, v/v) and water (85%, v/v). Mixtures were stirred for 5 min for extraction and centrifuged for 5 min at 2500 rpm to accelerate the phase separation.…”

Section: Supras Preparationmentioning

confidence: 99%

“…The application of SUPRASs to materials has been more limited. Recently, we developed a fast qualitative screening method for the analysis of BPA and analogs with SUPRASs loaded into ASAP probes, which were put in contact with thermal paper samples for few seconds before ASAP analysis by using low resolution MS/MS (Dueñas-Mas et al, 2022). In the present study, we apply the SUPRAS treatment in a separate step that is simple and fast, in order to make quantitative analysis easier.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Supramolecular Solvent Extraction and Ambient Mass Spectrometry for the Determination of Organic Contaminants in Food Packaging Material

Dueñas¹,

Dios-Pérez²,

Ballesteros‐Gómez³

et al. 2023

Preprint

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Section: Supras Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supramolecular Solvent Extraction and Ambient Mass Spectrometry for the Determination of Organic Contaminants in Food Packaging Material

Dueñas¹,

Dios-Pérez²,

Ballesteros‐Gómez³

et al. 2023

Preprint

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“…SUPRAS has mainly been applied for sample preparation and detection of trace substances, such as cadmium or bisphenols, in food and environmental samples [28,29]. However, they also have promising applications in the extraction of bioactive compounds from plants, especially because their safe and green properties are compatible with green fields such as food [30].…”

Section: Introductionmentioning

confidence: 99%

Green and efficient extraction of phenolic components from plants with supramolecular solvents: Experimental and theoretical studies

Xia,

Yu,

et al. 2024

Preprint

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Supramolecular solvent (SUPRAS) has received increasing interest as an innovative, efficient, and green solvent for the effective extraction and separation of bioactive compounds from natural resources. However, studies on the use of SUPRAS for the extraction of phenolic components from plants, which are highly valued in food products due to their excellent antioxidant capacity, are still lacking. The present study developed a green ultrasound-assisted and efficient SU-PRAS method to simultaneously determine three phenolic acids in Prunella vulgaris by high-performance liquid chromatography (HPLC) and the experimental parameters were optimized in detail. The efficiency and antioxidant properties of the phenolic compounds obtained by different extraction methods were also compared. Under the optimal conditions, the extraction efficiency of SUPRAS, prepared with octanoic acid reverse micelles dispersed in ethanol-water, was substantially higher than conventional organic reagents. Moreover, this SUPRAS method also showed more significant antioxidant capacities. The confocal laser scanning microscopy (CLSM) images presented the spherical droplet structure of SUPRAS (A well-defined circle), which coincided with the position of the fluorescence position of phenolic acids. The phenolic acids were encapsulated in the vesicles by the SUPRAS droplets, which indicated the efficient extraction capacities of SUPRAS for the target compounds. Finally, combined with the CLSM method, the mechanism of the proposed method was further clarified, and the superior extraction performance of SUPRAS was theoretically demonstrated through molecular dynamics simulations. In comparison with conventional methods, the higher extraction efficiency of SUPRAS can be illustrated by the larger solvent contact surface area, more types of hydrogen bonds between extractants and supramolecular solvents, and stronger and more stable interaction forces. The results of the theoretical studies are in rational agreement with the experimental outcome.

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“…The bypass of the chromatographic separation can lead to faster analytical methods, increasing the number of samples that can be scrutinized. Different ambient ionization techniques have been proposed in these couplings, including direct analysis in real time, − dielectric barrier desorption ionization, , atmospheric solids analysis probe, extractive-liquid sampling electron ionization mass spectrometry, or substrate spray ionization (SSI) . The latter technique is especially interesting due to its efficiency and simplicity.…”

Section: Introductionmentioning

confidence: 99%

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

López-Juan,

Millán-Santiago,

Benedé

et al. 2024

Anal. Chem.

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Direct coupling of sample preparation with mass spectrometry (MS) can speed up analysis, enabling faster decision-making. In such combinations, where the analysis time is mainly defined by the extraction procedure, magnetic dispersive solid-phase extraction emerges as a relevant technique because of its rapid workflow. The dispersion and retrieval of the magnetic sorbent are typically uncoupled stages, thus reducing the potential simplicity. Stir bar sorptive dispersive microextraction (SBSDME) is a novel technique that integrates both stages into a single device. Its miniaturization (mSBSDME) makes it more portable and compatible with low-availability samples. This article reports the direct combination of mSBSDME and MS using a needle-based electrospray ionization (NESI) emitter as the interface. This combination is applied to determine tetrahydrocannabinol in saliva samples, a relevant societal problem if the global consumption rates of cannabis are considered. The coupling requires only the transference of the magnet (containing the sorbent and the isolated analyte) from the mSBSDME to the hub of a hypodermic needle, where the online elution occurs. The application of 5 kV on the needle forms an electrospray on its tip, transferring the ionized analyte to the MS inlet. The excellent performance of mSBSDME-NESI-MS/MS relies on the sensitivity (limits of detection as low as 2.25 ng mL–1), the precision (relative standard deviation lower than 15%), and the accuracy (relative recoveries ranged from 87 to 127%) obtained. According to the results, the mSBSDME-NESI-MS/MS technique promises faster and more efficient chemical analysis in MS-based applications.

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Supramolecular solvent-based microextraction probe for fast detection of bisphenols by ambient mass spectrometry

Cited by 15 publications

References 39 publications

Supramolecular Solvent Extraction and Ambient Mass Spectrometry for the Determination of Organic Contaminants in Food Packaging Material

Supramolecular Solvent Extraction and Ambient Mass Spectrometry for the Determination of Organic Contaminants in Food Packaging Material

Green and efficient extraction of phenolic components from plants with supramolecular solvents: Experimental and theoretical studies

Coupling Miniaturized Stir Bar Sorptive Dispersive Microextraction to Needle-Based Electrospray Ionization Emitters for Mass Spectrometry: Determination of Tetrahydrocannabinol in Human Saliva as a Proof of Concept

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