Supranutritional Maternal Organic Selenium Supplementation during Different Trimesters of Pregnancy Affects the Muscle Gene Transcriptome of Newborn Beef Calves in a Time-Dependent Manner

Diniz, Wellison J. S.; Bobe, Gerd; Klopfenstein, Joseph J.; Gultekin, Yunus; Davis, T. Zane; Ward, Alison K; Hall, Jean A.

doi:10.3390/genes12121884

Cited by 11 publications

(9 citation statements)

References 59 publications

(103 reference statements)

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“…Compared with no treatment, maternal supplementation with Se-yeast boluses (105 mg of Se/week) during the third trimester was associated with increased expression of myosin and actin filament associated genes in newborn calves. These genes are involved in muscle development, potentially allowing for optimal muscle growth, functioning, and contraction [66]. In summary, Se dysregulation evokes muscular dysfunction by interfering with signaling that regulates muscle cell survival and activates atrophy genes [43,55,61], while Se supplementation during the third trimester can promote muscle growth [66], lower muscle loss, and improve meat quality [64,65].…”

Section: Selenium Deficiency In Livestockmentioning

confidence: 99%

“…These genes are involved in muscle development, potentially allowing for optimal muscle growth, functioning, and contraction [66]. In summary, Se dysregulation evokes muscular dysfunction by interfering with signaling that regulates muscle cell survival and activates atrophy genes [43,55,61], while Se supplementation during the third trimester can promote muscle growth [66], lower muscle loss, and improve meat quality [64,65]. Notably, Se supplementation during the first and second trimester has a potentially adverse effect on the development of muscle and collagen structures [66].…”

Section: Selenium Deficiency In Livestockmentioning

confidence: 99%

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Effects of Selenium Supplementation on Rumen Microbiota, Rumen Fermentation, and Apparent Nutrient Digestibility of Ruminant Animals: A Review

et al. 2021

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Enzymes excreted by rumen microbiome facilitate the conversion of ingested plant materials into major nutrients (e.g., volatile fatty acids (VFA) and microbial proteins) required for animal growth. Diet, animal age, and health affect the structure of the rumen microbial community. Pathogenic organisms in the rumen negatively affect fermentation processes in favor of energy loss and animal deprivation of nutrients in ingested feed. Drawing from the ban on antibiotic use during the last decade, the livestock industry has been focused on increasing rumen microbial nutrient supply to ruminants through the use of natural supplements that are capable of promoting the activity of beneficial rumen microflora. Selenium (Se) is a trace mineral commonly used as a supplement to regulate animal metabolism. However, a clear understanding of its effects on rumen microbial composition and rumen fermentation is not available. This review summarized the available literature for the effects of Se on specific rumen microorganisms along with consequences for rumen fermentation and digestibility. Some positive effects on total VFA, the molar proportion of propionate, acetate to propionate ratio, ruminal NH3-N, pH, enzymatic activity, ruminal microbiome composition, and digestibility were recorded. Because Se nanoparticles (SeNPs) were more effective than other forms of Se, more studies are needed to compare the effectiveness of synthetic SeNPs and lactic acid bacteria enriched with sodium selenite as a biological source of SeNPs and probiotics. Future studies also need to evaluate the effect of dietary Se on methane emissions.

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Section: Selenium Deficiency In Livestockmentioning

confidence: 99%

Section: Selenium Deficiency In Livestockmentioning

confidence: 99%

Effects of Selenium Supplementation on Rumen Microbiota, Rumen Fermentation, and Apparent Nutrient Digestibility of Ruminant Animals: A Review

et al. 2021

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“…In the current study, Se supplementation of dams during the last trimester of pregnancy was better suited than during earlier trimesters of pregnancy to accumulate Se-body reserves in calves. In support, we observed higher muscle Se concentrations in calves of TR-3 cows compared with calves from CTR or TR-1 and TR-2 cows [ 37 ].…”

Section: Discussionmentioning

confidence: 60%

“…Interestingly, the calves from TR-1 dams in the current study had lower birth weights compared with the calves from CTR dams. This was likely because the genes involved in muscle development (specifically muscle-structure-related genes) were downregulated in the TR-1 calves compared with the CTR calves [ 37 ]. In addition, the TR-1 calves tended to have a higher proportion graded select at slaughter compared with the other two Se-supplemented groups combined.…”

Section: Discussionmentioning

confidence: 99%

“…The hot carcass weight of the calves from TR-2 cows tended to be lower compared with the calves from CTR cows ( p = 0.07). In addition, we previously reported that the genes involved in collagen formation were downregulated in the muscle of newborn beef calves of TR-2 vs. CTR cows [ 37 ]. Given that the growth characteristics of the calves from TR-1 and TR-2 cows were inferior to the calves of CTR cows, supranutritional maternal Se supplementation throughout pregnancy is not recommended.…”

Section: Discussionmentioning

confidence: 99%

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Supranutritional Selenium-Yeast Supplementation of Beef Cows during the Last Trimester of Pregnancy Results in Higher Whole-Blood Selenium Concentrations in Their Calves at Weaning, but Not Enough to Improve Nasal Microbial Diversity

Hall

Isaiah

McNett

et al. 2022

Animals

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We previously reported that feeding Se-biofortified alfalfa hay to weaned beef calves in a preconditioning program increases whole-blood Se (WB-Se) concentrations and nasal microbiome abundance and diversity during the preconditioning period, decreases morbidity and mortality during the feedlot period, and increases carcass weight and quality at slaughter. The objective of the current study was to see whether similar improvements can be achieved through Se supplementation of dams during various pregnancy trimesters. In a two-year experimental study, 80 Angus-cross cows received once-weekly Se-yeast boluses containing 105 mg of Se, during either the first (TR-1), second (TR-2), or third (TR-3) pregnancy trimester, or were not bolused (CTR). Whole-blood Se concentrations were higher from CTR, to TR-1, to TR-2, and to TR-3 in newborn calves (all p < 0.01). At weaning, only calves from TR-3 mothers had higher WB-Se concentrations compared with calves from CTR mothers (p = 0.02), and no significant differences in nasal microbiome abundance and diversity or nasal microbiota were observed. In the feedlot period, morbidity was low, and no differences were observed. At slaughter, no differences in carcass weight and quality were observed. In conclusion, Se supplementation of pregnant cows is effective for increasing WB-Se concentration of newborn calves, and the increase can be sustained until weaning for calves born to TR-3 dams. However, the increase in WB-Se concentrations is small and does not result in beneficial changes in the nasal microbiome. Thus, calves should be fed Se-biofortified forages again at weaning in a preconditioning program in order to diversify the nasal microbiome prior to entering the feedlot.

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Epigenetics and Nutrition: Molecular Mechanisms and Tissue Adaptation in Developmental Programming

Diniz,

Reynolds,

Ward

et al. 2024

Epigenetics and Human Health

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Supranutritional Maternal Organic Selenium Supplementation during Different Trimesters of Pregnancy Affects the Muscle Gene Transcriptome of Newborn Beef Calves in a Time-Dependent Manner

Cited by 11 publications

References 59 publications

Effects of Selenium Supplementation on Rumen Microbiota, Rumen Fermentation, and Apparent Nutrient Digestibility of Ruminant Animals: A Review

Effects of Selenium Supplementation on Rumen Microbiota, Rumen Fermentation, and Apparent Nutrient Digestibility of Ruminant Animals: A Review

Supranutritional Selenium-Yeast Supplementation of Beef Cows during the Last Trimester of Pregnancy Results in Higher Whole-Blood Selenium Concentrations in Their Calves at Weaning, but Not Enough to Improve Nasal Microbial Diversity

Epigenetics and Nutrition: Molecular Mechanisms and Tissue Adaptation in Developmental Programming

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