Suprathreshold laser injuries in excised porcine skin for millisecond exposures at 1070 nm

Abstract

Skin injury response to near-infrared (NIR) laser radiation between the minimum visible lesion threshold and ablation onset is not well understood. This study utilizes a 1070-nm diode-pumped Yb-fiber laser to explore the response of excised porcine skin to high-energy exposures in the suprathreshold injury region without inducing ablation. Concurrent high-speed videography is employed to determine a dichotomous response for three progressive damage categories: observable surface distortion, surface bubble formation due to contained intracutaneous water vaporization, and surface bubble rupture during exposure. Median effective dose (ED 50 ) values are calculated in these categories for 3-and 100-ms pulses with beam diameters (1∕e 2 ) of 3 mm (28, 35, and 49 J∕cm 2 ) and 7 mm (96, 141, and 212 J∕cm 2 ), respectively. Double-pulse cases are secondarily investigated. Experimental data are compared with the maximum permissible exposure limits and ablation onset simulated by a one-dimensional multiphysics model. Logistic regression analysis predicted injury events with ∼90% of accuracy. The distinction of skin response into progressive damage categories expands the current understanding of high-energy laser safety while underlining the unique biophysical effects during induced water phase change in tissue. These results prove to be useful in the diagnosis and treatment of NIR laser injuries.

Thermal damage thresholds for multiple-pulse porcine skin laser exposures at 1070 nm

“…Subsequent studies also explored the 1060-nm wavelength for both human and porcine subjects, for 1-s 4,5 and 0.2-to 0.3-s 6,7 exposures. A recent study by Vincelette et al 8 determined the contribution of beam diameter to porcine skin MVL thresholds for 1070-nm laser exposure durations ranging from 10 ms to 10 s. DeLisi et al 9 further investigated skin injury response to 1070-nm lasers but at suprathreshold endpoints for 3-and 100-ms exposures in excised porcine tissue. Cain et al 10 and Montes de Oca et al 11 presented porcine skin MVL thresholds for light near 1315 nm and pulse durations of 0.35 ms, whereas Oliver et al 12 provided thresholds at 1319 nm for exposure durations of 0.25, 1, 2.5, and 10 s. Several porcine skin MVL threshold studies for 1540-nm laser are available, including for 30-ns, 13,14 0.6-, 13 0.8-, 15 and 60-ms pulses.…”