The human body is known as a thermodynamic system that interacts with the environment. Wetting and drying events are essential factors that affecting the physiological comfort of clothes and depending on many parameters such as fiber type, yarn structure, knitting structure, fabric thickness, or finishing processes etc. For removing the sweat quickly and keep the body dry, knowing wetting and drying behavior of textiles is important in terms of clothing comfort. In this experimental research, cotton and tencel fibers are used which can be known as comfort fibers. By using the yarns produced from these fibers, single jersey knitted fabric surfaces have been formed in the circular knitting machine. The obtained fabrics are colored by digital printing method. Fabrics were tested before and after digital printing because of measuring the effect of digital printing on drying behavior. Interaction of samples with water were analyzed by testing out transfer capillary wetting ability test and drying time determination. It was observed that, the time-dependent rate of drying-thus the mass loss-and transfer capillary wetting ability were consistent with the results found in the literature.