Nitrile (Tab. 1) werden durch Umsetzung mit Ameisensaure und Chlor-bzw. Bromwasserstoff in Carbonsaureamide ubergefiihrt. Das Verfahren erfordert weder erhohten Druck noch erhohte Temperatur. Auch die partielle Verseifung von Polynitrilen zu Monoamiden ist moglich. Ausbeute und Reinheit der nach dieser Methode hergestellten Amide sind sehr gut.
SummaryA method of preparing 18 O-labelled nicotinamide, involving cyanopyridine, H 2 18 O, and 1,1 0 3,3 0 -tetramethylguanidine as a catalyst is described. The desired product is produced in 91% chemical yield and 97.5% isotopic incorporation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.