Surface Activities, Antibacterial Activity and Corrosion Inhibition Properties of Gemini Quaternary Ammonium Surfactants with Amido Group and Carboxylic Counterions

Hu, Sien; Fu, Duojiao; Chen, Hanyu; Liu, Hongqin; Xu, Bin

doi:10.5650/jos.ess19339

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…In turn, Liu and collaborators obtained amide-linked GS 46 bearing diverse counterions (Scheme 25). Bacteriostatic activity against P. aeruginosa, E. coli, and B. subtilis was higher at 50 µg/mL than that of BAC, even at 100 µg/mL [112][113][114]. Akram and coworkers designed and synthesized eco-friendly ester-ether GS 47 (Scheme 26).…”

Section: Gemini Surfactants and Polycationic Qacsmentioning

confidence: 99%

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds

Fedorowicz,

Sączewski

2024

IJMS

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This review provides a comprehensive overview of recent advancements in the design and synthesis of biologically active quaternary ammonium compounds (QACs). The covered scope extends beyond commonly reviewed antimicrobial derivatives to include synthetic agents with antifungal, anticancer, and antiviral properties. Additionally, this review highlights examples of quaternary ammonium compounds exhibiting activity against protozoa and herbicidal effects, as well as analgesic and anesthetic derivatives. The article also embraces the quaternary-ammonium-containing cholinesterase inhibitors and muscle relaxants. QACs, marked by their inherent permanent charge, also find widespread usage across diverse domains such as fabric softeners, hair conditioners, detergents, and disinfectants. The effectiveness of QACs hinges greatly on finding the right equilibrium between hydrophilicity and lipophilicity. The ideal length of the alkyl chain varies according to the unique structure of each QAC and its biological settings. It is expected that this review will provide comprehensive data for medicinal and industrial chemists to design and develop novel QAC-based products.

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Section: Gemini Surfactants and Polycationic Qacsmentioning

confidence: 99%

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds

Fedorowicz,

Sączewski

2024

IJMS

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“…The potential uses and applications of Gemini surfactants lie in their unique physical properties, most notably their low cmcs (critical micelle concentrations), good wettabilities and surface tension lowering properties. Potential applications include oil spill remediation agents [1], anti-corrosives [2,3], antimicrobial and anti-algal agents [3][4][5][6] and gene therapy [8] to name a few. The major features governing the physical properties of a dicationic Gemini surfactant are:…”

Section: Introductionmentioning

confidence: 99%

Gemini surfactants with short linkers: thermodynamics of Micelle formation

Sutorius,

McKim,

Aquilar

et al. 2024

J Therm Anal Calorim

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We have been investigating the physical properties of simple Gemini surfactant with short linker chains using conductivity, dynamic light scattering (DLS) and isothermal titration calorimetry (ITC). The surfactants used here have the general formula (CH3(CH2)11)(CH3)2-N+-(CH2)n-N+(CH3(CH2)11)(CH3)2·Br2, where n = 2, 3 or 4 and, as such, are designated as 12-2-12, 12-3-12 and 12-4-12. The ultimate goal of this work was to determine the enthalpy of demicellization using ITC. To determine the proper experimental conditions, it was necessary to first determine the critical micelle concentration (cmc) using conductivity and the size of the formed micelles using DLS for each surfactant. The results indicate a number of linear relationships between the number of carbons in the linker and certain physical properties such as cmc and ΔGmic as determined by conductivity studies. As expected, demicellization is enthalpically unfavorable but entropically driven. Linear relationships are also observed between the number of linker carbons and some thermodynamic properties as determined by ITC. Graphical abstract

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“…Gemini surfactants are getting increased attention because of their unique physical properties, most notably their low cmc s (critical micelle concentrations), good wettabilities, and surface tension-lowering properties. Potential applications range from oil spill remediation agents, anticorrosives, , and antimicrobial and antialgal agents − to gene therapy agents , for example.…”

Section: Introductionmentioning

confidence: 99%

The Interaction of a Gemini Surfactant with a DNA Quadruplex

Howard,

Little,

Boatwright

et al. 2024

ACS Omega

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DNA secondary structures are stabilized by mono-and divalent cations. To examine the stability of the DNA quadruplex formed from (TTAGGG) 4 , its interaction with a dicationic Gemini surfactant in standard phosphate buffer was investigated. The Gemini surfactant begins to form micelles in buffer at a cmc (critical micelle concentration) of 1.5 mM. In this study, solutions of DNA were prepared in buffer with surfactant concentrations ranging from 0.0 to 3.0 mM, i.e., above and below the cmc of the surfactant. In all samples of DNA and surfactant, a precipitate formed. The fraction of DNA precipitated depends upon both the initial DNA concentration and the initial concentration of the surfactant. In those samples where the DNA did not totally precipitate, the residual DNA assumed a quadruplex conformation. It was determined that two surfactant molecules per DNA phosphate are needed to completely precipitate all of the DNA in a particular sample. An estimated apparent K sp for the DNA:surfactant complex was determined.

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Surface Activities, Antibacterial Activity and Corrosion Inhibition Properties of Gemini Quaternary Ammonium Surfactants with Amido Group and Carboxylic Counterions

Cited by 9 publications

References 20 publications

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds

Gemini surfactants with short linkers: thermodynamics of Micelle formation

The Interaction of a Gemini Surfactant with a DNA Quadruplex

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