Surface amplification of pencil graphite electrode with polypyrrole and reduced graphene oxide for fabrication of a guanine/adenine DNA based electrochemical biosensors for determination of didanosine anticancer drug

Karimi-Maleh, Hassan; Bananezhad, Asma; Ganjali, Mohammad Reza; Norouzi, Parviz; Sadrnia, Abdolhossein

doi:10.1016/j.apsusc.2018.01.237

Cited by 115 publications

(26 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LOD of 50 pg mL −1 and 1 ng mL −1 was determined for VEGF and PSA, respectively. In another study performed by Karimi‐Maleh and his team, it was found that graphene performed a significant role in signal amplification and construction of ultrasensitive DNA sensing probe for detection of didanosine (DDI) . A pencil graphite electrode functionalized with polypyrrole (PPy) and rGO (PGE/PPy/rGO) was utilized to immobilize dsDNA forming the final sensing probe.…”

Section: Carbon Based Nmmentioning

confidence: 99%

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

et al. 2019

View full text Add to dashboard Cite

The design and development of modern biosensors for sensitive and selective detection of various biomarkers is important in diversified arenas including healthcare, environment, and food industries etc. The requirement of more robust and reliant biosensors lead to the development of various sensing modules. The nanomaterials having specific optical, electrical, and mechanical strength can pave the way towards development of ultrafast, robust, and miniaturized modules for biosensors. It can provide not only the point‐of‐care applicability but also has tremendous commercial as well as industrial justification. In order to improve the performance of the sensor systems, various nanostructure materials have been readily studied and applied for development of novel biosensors. In the last few years, researchers are engaged on harnessing the unique atomic and molecular properties of advance‐engineered materials including carbon nanotubes, graphene nanosheets, metal nanoparticles, metal oxide nanoparticles, and their nano‐conjugates. In view of such recent developments in nanomaterial engineering, the current review has been formulated emphasizing the role of these materials in surface engineering, biomolecule conjugation, and signal amplification for development of various ultrasensitive and robust biosensors having commercial as well as industrial viability. Attention is given on the electrochemical biosensors incorporating various nanomaterials and their conjugates. Importance of nanomaterials in the analytical performance of the various biosensor has also been discussed. To put a perceptive insights on the importance of various nanomaterials, an extended table is incorporated, which includes probe design, analyte, LOD, and dynamic range of various electrochemical biosensors.

show abstract

Section: Carbon Based Nmmentioning

confidence: 99%

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

et al. 2019

View full text Add to dashboard Cite

show abstract

“…These nanoparticles provide the researchers with more efficient techniques for interfacing DNA recognition with electrochemical signal transduction. The recent electrochemical drug‐DNA binding studies based on nanomaterials are summarized in Table ; the types of drugs that have been analyzed are anticancer agents antibiotics, antihistaminic, antivirals, nonsteroidal anti‐inflammatory drugs, neurotransmitters, vitamins and retroviral . Upon discovery of the advantages that nanomaterials could bring to analytical science, the first researches regarding to DNA‐drug interaction were done in solution.…”

Section: Nanomaterialsmentioning

confidence: 99%

“…Using the drug−DNA interaction, useful analytical information can be obtained from the increased DNA (guanine) response, in a manner that one can determine several drugs concentration using an electrochemical approach in complex biological matrices .…”

Section: Nanomaterialsmentioning

confidence: 99%

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

View full text Add to dashboard Cite

The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA‐targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA‐targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug‐DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug‐nucleic acid interaction. We summarize types of drug‐DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring.

show abstract

“…In the study, gold‐silver (Au−Ag) nanocomposite has been adsorbed on electrochemically fabricated polypyrrole coated platinum (Pt) electrode. Karimi‐Maleh and his colleagues have presented a polypyrrole and reduced graphene oxide deposited pencil graphite electrode for the electrochemical detection of anticancer drug didanosine (PGE) …”

Section: Introductionmentioning

confidence: 99%

Polypyrrole‐Based Nanohybrid Electrodes: Their Preparation and Potential Use for DNA Recognition and Paclitaxel Quantification

Kuralay

Dükar

2020

ChemistrySelect

View full text Add to dashboard Cite

Fabrication of conducting polymer networks based on polypyrrole/multi-walled carbon nanotubes (PPy/MWCNTs) modified graphite electrodes that were achieved with a single-step electropolymerization and potential use of these electrodes for deoxyribonucleic acid (DNA) recognition and anticancer drug (Paclitaxel, PTX) quantification were presented in the present work. PPy/MWCNTs nanohybrid PGEs were constructed in aqueous solution of pyrrole (Py) and MWCNTs using cyclic voltammetry (CV) and constant potential electrolysis. Soformed electrodes were characterized with cyclic voltammetry and electrochemical impedance spectroscopy (EIS). Surface morphologies of the surfaces were investigated by scanning electron microscopy (SEM) studies. Bio-application of the PPy/ MWCNTs nanohybrid modified PGEs were accomplished by subjecting them to double-stranded DNA (dsDNA) modification for direct DNA recognition and PTX determination. For the drug determination, interaction of DNA-based electrodes with PTX was investigated. Detection limit was found as 1.55 x 10 À 8 M based on the changes in the oxidation of guanine base which made the proposed electrode convenient for clinical trials.

show abstract

Surface amplification of pencil graphite electrode with polypyrrole and reduced graphene oxide for fabrication of a guanine/adenine DNA based electrochemical biosensors for determination of didanosine anticancer drug

Cited by 115 publications

References 37 publications

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

Polypyrrole‐Based Nanohybrid Electrodes: Their Preparation and Potential Use for DNA Recognition and Paclitaxel Quantification

Contact Info

Product

Resources

About