Surface and depth profile investigation of a phosphorylcholine-based contact lens using time of flight secondary ion mass spectrometry

Braun, Robert M.; Ingham, Scott J.; Harmon, Patricia S.; Hook, Daniel

doi:10.1116/1.2432350

Cited by 5 publications

(2 citation statements)

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“…Some researchers showed the surface changes by AFM after daily wear to investigate the wearing effect of the lens [26,27]. Surface techniques such as X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were also used to analyze the pigment distribution as well as lens materials [28][29][30][31][32][33][34][35]. Among the surface analytical techniques, AFM is a wellestablished technique for flatness analysis and imaging of biomaterial surfaces so that it has been often used to analyze the roughness of various soft contact lenses [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

Kim

Lee

Jang

et al. 2020

Journal of Analytical Methods in Chemistry

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Over the years, soft contact lenses for vision correction and cosmetic and therapeutic purposes have been greatly improved. For cosmetic contact lenses, the pigments need to be nontoxic, and the position of the pigment layer is particularly important because of the risks posed by pigment elution and the roughness of the lens surface. In this paper, we characterized the properties of brown cosmetic contact lenses made by three different manufacturers using surface analytical techniques. The surface topographies of the noncolored and colored parts were obtained by atomic force microscopy (AFM), and the position and composition of the pigment layer were determined by analyzing the cross section of the contact lenses using scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX). The influence of pigment location on surface roughness was also examined. In addition, to find the method of the evaluation for the risk of surface elution of the pigments in the colored parts, the mass spectra and ion images of the surfaces were obtained by time-of-flight secondary ion mass spectrometry (ToF-SIMS) with a new sample preparation. From the ToF-SIMS spectra, we observed specific fragment ions of the poly(hydroxyethyl methacrylate) (PHEMA) polymer and found differences in the composition of the pigment layer depending on the manufacturers. The cross-sectioned image and 3D chemical characterizations of metallic and specific ions in the brown cosmetic contact lenses clearly indicated the spatial distribution and location of the pigment layer that can be used for the evaluation of pigment elution.

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Section: Introductionmentioning

confidence: 99%

“…Above all, ToF-SIMS has been used to obtain the surface chemical information of contact lenses [30][31][32][33][34][35]. It has previously been used to investigate soft contact lens materials, providing chemical information on the surface.…”

Section: Introductionmentioning

confidence: 99%

ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

Kim

Lee

Jang

et al. 2020

Journal of Analytical Methods in Chemistry

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Current literature in mass spectrometry

2008

J. Mass Spectrom.

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Localization of Lysozyme Sorption to Conventional and Silicone Hydrogel Contact Lenses Using Confocal Microscopy

Luensmann

Zhang

Subbaraman

et al. 2009

Current Eye Research

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Surface and depth profile investigation of a phosphorylcholine-based contact lens using time of flight secondary ion mass spectrometry

Cited by 5 publications

References 28 publications

ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

ToF-SIMS and AFM Characterization of Brown Cosmetic Contact Lenses: From Structural Analysis to the Identification of Pigments

Current literature in mass spectrometry

Localization of Lysozyme Sorption to Conventional and Silicone Hydrogel Contact Lenses Using Confocal Microscopy

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