Surface Characterization and Hemocompatibility of Heparinized 316l Stainless Steel

Chuang, Tzu-Wen; Lin, Fa‐Hsuan

doi:10.1142/s1016237208000544

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Although drug eluting stents are effective against restenosis, increased rates of late thrombosis have raised doubts as to their safety [3,4]. In recent years, considerable efforts have been made to reduce in-stent acute, subacute, and late thrombosis [5][6][7]. Surface modification is a widely used approach for improving the anticoagulant activity of blood contacting devices.…”

Section: Introductionmentioning

confidence: 99%

A novel antithrombotic coronary stent: lysine-poly(HEMA)-modified cobalt–chromium stent with fibrinolytic activity

Wang

Chen

et al. 2012

Journal of Biomaterials Science, Polymer Edition

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Prevention of coagulation appears not to be possible when a foreign surface is in contact with blood; the alternative concept of a clot lysing surface has therefore been suggested. In this work, a mimic of the fibrinolytic system was constructed on L605 cobalt-chromium coronary stents. Lysine which, immobilized on a surface, has been shown previously to adsorb plasminogen in contact with blood was attached to the stent using poly(2-hydroxyethyl methacrylate) (poly(HEMA)) as a spacer. The lysine-poly(HEMA) modified stent was shown to have low nonspecific protein adsorption and to bind plasminogen in high quantity from plasma. Following exposure to plasma and treatment with tissue plasminogen activator, the lysine-modified stents showed clot-lysing properties in vitro while the unmodified L605 stents did not. It was shown that the modified stents retained their clot lysing properties after 24 h exposure to plasma.

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