Surface charge impact in nonsynaptic model of epilepsy in rat hippocampus

Zapukhliak, O.S.; Kachanovska, V O; Isaeva, Elena; Netsyk, Olga; Isaev, Dmytro

doi:10.15407/fz62.02.035

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Slice preparation. The method used in this study for preparation of acute rat brain slices was described previously [17]. Briefly, animals were deeply anesthetized with sevoflurane and decapitated.…”

Section: Methodsmentioning

confidence: 99%

Mecamylamine modulates epileptiform discharges in low-Mg2+ model of epilepsy

Zapukhliak¹,

Isaev²

2021

Fiziol Zh

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Mecamylamine is a nonselective antagonist of nicotinic acetylcholine receptors that was developed as an antihypertensive medication and is now being studied for its beneficial effects in several pathological conditions, such as substance abuse, depression, anxiety and epilepsy. In this work, we investigate the effect of mecamylamine on the manifestations of seizure-like activity evoked by perfusion of hippocampal slices with low-Mg2+ solution of artificial cerebrospinal fluid. Reducing Mg2+ concentration in extracellular solution induced two distinct types of epileptiform activity: recurring seizure-like activity and continuous discharges. Application of mecamylamine significantly increased internal frequency of recurring seizurelike activity and significantly decreased inter-event intervals between continuous discharges. We also show that mecamylamine significantly decreased internal frequency of continuous epileptiform discharges. The results of our work show that mecamylamine exerts modulatory effect on the low-Mg2+ epileptiform activity induced in hippocampal acute rat brain slices. Additionally, obtained results indicate the role of nicotinic acetylcholine receptors in the modulation of hippocampal network activity, which might explain some of the therapeutic effects of mecamylamine in CNS.

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Section: Methodsmentioning

confidence: 99%

Mecamylamine modulates epileptiform discharges in low-Mg2+ model of epilepsy

Zapukhliak¹,

Isaev²

2021

Fiziol Zh

Self Cite

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Precision drug delivery to the central nervous system using engineered nanoparticles

Gao,

Xia,

Gunasekar

et al. 2024

Nat Rev Mater

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Russia-Japan fishery Relations under sanctions

Kurmazov

2022

Fisheries

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The problem of the influence of anti-Russian sanctions did not immediately affect Russian-Japanese relations in the field of fisheries, but began to manifest itself in rather unexpected ways. The impact of sanctions on the negotiation process on fisheries between Russia and Japan, the problem of non-payments is considered. Also, the impact of sanctions on the supply of Norwegian salmon to Japan, since the delivery routes passed through the sky of Russia, now it is closed to many countries. Fish products from Russia continue to be in high demand on the world market even under sanctions. Therefore, the import of fish by many countries from Russia remains high. In the Russian press, the issue of sanctions in Russian-Japanese fishing relations is covered little and insufficiently competently. The author's analysis of the problem is mainly based on publications in the Japanese media and Japanese government publications.

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Surface charge impact in nonsynaptic model of epilepsy in rat hippocampus

Abstract: Decreasing of surface charge screening near voltage-gated ion channels via reduction of extracellular

Cited by 3 publications

References 25 publications

Mecamylamine modulates epileptiform discharges in low-Mg2+ model of epilepsy

Mecamylamine modulates epileptiform discharges in low-Mg2+ model of epilepsy

Precision drug delivery to the central nervous system using engineered nanoparticles

Russia-Japan fishery Relations under sanctions

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