Surface chemistry driven selective anticancer potential of functional silver nanoparticles toward lung cancer cells

Umapathi, Akhela; Madhyastha, Harishkumar; Pn, Navya; Singh, Mandeep; Madhyastha, Radha; Daima, Hemant Kumar

doi:10.1016/j.colsurfa.2022.129809

Cited by 5 publications

(2 citation statements)

References 66 publications

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“…Umapathi et al studied the anti-cancer potential of AgNPs synthesized using curcumin extract and functionalized with isonicotinic acid hydrazide in LK-2 lung cancer cells. 58 A previous study reported that AgNPs significantly inhibit the proliferative activity of malignant cells, owing to their potential to enhance reactive oxygen species formation. In contrast, NPs displayed antioxidant potential in normal lung fibroblasts (WI-38).…”

Section: Resultsmentioning

confidence: 99%

Biofabrication of Silver Nanoparticles Using Nostoc muscorum Lukesova 2/91: Optimization, Characterization, and Biological Applications

Hamida,

Ali,

Sharif

et al. 2023

IJN

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Purpose The biological synthesis of nanoparticles (NPs) has become a new methodology for the eco-friendly production of NPs with high scalability and biocompatibility. Cyanobacteria are one of the most widespread microorganisms on Earth and have been proven to be successful biofactories for synthesizing NPs. It is challenging to discover new microalgae with the potential to synthesize NPs of small size with high stability. Methods Nostoc muscorum Lukesova 2/91 was isolated, purified, and identified morphologically and genetically using microscopy and DNA sequencing. Volatile biomolecules in aqueous algal extracts were assessed using gas chromatography-mass spectroscopy (GC-MS). Results Data showed that the main biomolecules were fatty acids and their esters, followed by secondary metabolites. Algal extract was used to convert silver nitrate (AgNO 3 ) into silver NPs under various optimized parameters. 1 mM of AgNO 3 , 1:1 (V/V ratio of algal extract to AgNO 3 ), 25 °C, under light illumination, for 24 h, at pH 7.4 were the optimum conditions for NP production (Nos@AgNPs). Nos@AgNPs were characterized using UV-VIS spectroscopy, FTIR, TEM, SEM, EDx, mapping, and a Zetasizer. The wavelength of Nos@AgNPs was 401.4 nm and their shapes were cubic to oval, with an average diameter of 11.8 ± 0.5 nm. FTIR spectroscopy revealed that proteins/polysaccharides could be the main reductants, whereas these molecules and/or fatty acids could be stabilizers for NP synthesis. Nos@AgNPs (86.15%) was silver and had a hydrodynamic diameter of 10.7 nm with a potential charge of −19.7 mV. Antiproliferative and antimicrobial activities of Nos@AgNPs were evaluated. Nos@AgNPs exhibited significant inhibitory activity against lung, colon, and breast cancer cells and considerable biocidal activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia , and Pseudomonas aeruginosa . Conclusion N. muscorum Lukesova 2/91 is an excellent source for the biofabrication of small and stable AgNPs with potent inhibitory effects against cancer and bacterial cells.

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Section: Resultsmentioning

confidence: 99%

Biofabrication of Silver Nanoparticles Using Nostoc muscorum Lukesova 2/91: Optimization, Characterization, and Biological Applications

Hamida,

Ali,

Sharif

et al. 2023

IJN

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“…The cytotoxic behavior of nanomaterials mainly depends on their several physicochemical properties including morphology, shape, size, surface chemistry, surface area, composition, and action mechanism. ,,,,− Results revealed that exposure of nanomaterials induces ROS generation in a pro-inflammatory state, which further leads to membrane, protein, and lipid damage. Immune system continuous activation causes the development of several allergic and autoimmune diseases.…”

Section: Complications Associated With Nanomaterials-mediated Immune ...mentioning

confidence: 99%

Engineered Nanomaterials for Immunomodulation: A Review

Singh,

Kumawat,

Gogoi

et al. 2024

ACS Appl. Bio Mater.

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The immune system usually provides a defense against invading pathogenic microorganisms and any other particulate contaminants. Nonetheless, it has been recently reported that nanomaterials can evade the immune system and modulate immunological responses due to their unique physicochemical characteristics. Consequently, nanomaterial-based activation of immune components, i.e., neutrophils, macrophages, and other effector cells, may induce inflammation and alter the immune response. Here, it is essential to distinguish the acute and chronic modulations triggered by nanomaterials to determine the possible risks to human health. Nanomaterials size, shape, composition, surface charge, and deformability are factors controlling their uptake by immune cells and the resulting immune responses. The exterior corona of molecules adsorbed over nanomaterials surfaces also influences their immunological effects. Here, we review current nanoengineering trends for targeted immunomodulation with an emphasis on the design, safety, and potential toxicity of nanomaterials. First, we describe the characteristics of engineered nanomaterials that trigger immune responses. Then, the biocompatibility and immunotoxicity of nanoengineered particles are debated, because these factors influence applications. Finally, future nanomaterial developments in terms of surface modifications, synergistic approaches, and biomimetics are discussed.

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Recent Development and Importance of Nanoparticles in Disinfection and Pathogen Control

Verma,

Sharma,

Awasthi

et al. 2023

Smart Nanomaterials Technology

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Surface chemistry driven selective anticancer potential of functional silver nanoparticles toward lung cancer cells

Cited by 5 publications

References 66 publications

Biofabrication of Silver Nanoparticles Using Nostoc muscorum Lukesova 2/91: Optimization, Characterization, and Biological Applications

Biofabrication of Silver Nanoparticles Using Nostoc muscorum Lukesova 2/91: Optimization, Characterization, and Biological Applications

Engineered Nanomaterials for Immunomodulation: A Review

Recent Development and Importance of Nanoparticles in Disinfection and Pathogen Control

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