Surface coating affects uptake of silver nanoparticles in neural stem cells

Pongrac, I; Ahmed, Lada Brkić; Mlinarić, Hrvoje; Jurašin, Darija Domazet; Pavičić, Ivan; Čermak, Ana Marija Marjanović; Milić, Mirta; Gajović, Srećko; Vrček, Ivana Vinković

doi:10.1016/j.jtemb.2017.12.003

Cited by 29 publications

(21 citation statements)

References 35 publications

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“…At cellular level, generation of reactive oxygen species (ROS) and oxidative stress, alteration of mitochondrial function, inflammation, and induction of DNA damage have been reported as the most plausible mechanisms of AgNP toxicity, although detailed and consistent data are still missing. We have also demonstrated a similar mode of toxic actions for AgNPs in a wide range of mammalian cells including liver, kidney, and brain cells …”

Section: Introductionsupporting

confidence: 53%

“…Generation of ROS during oxidative stress, as demonstrated by data presented in Figures and , may attack DNA and induce mutagenic lesions. We have already evidenced the genotoxicity of different AgNPs in vitro . Therefore, the genotoxic effect of protein versus polymer‐coated AgNPs was evaluated in all collected body compartments of male and female Wistar rats using the alkaline comet assay.…”

Section: Resultsmentioning

confidence: 99%

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Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo

Barbir

Goessler

Ćurlin

et al. 2019

Part & Part Syst Charact

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Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall applications. Despite their wide use, detailed toxicokinetic data and information on their action mechanisms in vivo are still scarce. One important obstacle is their fate and transformation patterns in biological environments where AgNPs get a “new face” after interaction with biomolecules, particularly proteins. The impact of protein corona on AgNP effects in vivo is eludicated. The in vivo effects of AgNPs prepared with two different protein coronas, albumin, and metallothionein, with polymer‐coated AgNPs are compared in male and female Wistar rats after intravenous administration. The results demonstrate that the character of the protein coronas on the AgNP surface affects not only distribution, but also oxidative stress response and genotoxicity in tissues of rat exposed to AgNPs. Additionally, sex‐related effects are observed. By emphasizing the importance of protein corona formation and sex‐related response, the obtained data support a reliable evidence base needed for assessing the health risks of the steadily increasing human exposure to AgNPs.

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Section: Introductionsupporting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo

Barbir

Goessler

Ćurlin

et al. 2019

Part & Part Syst Charact

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“…Luther et al showed that Fe NPs were successfully taken up by microglial cells chiefly through macropinocytosis and clathrin-mediated endocytosis, in the course of which absorbed particles were directed into the lysosomal compartment [70]. A predominance of endocytosis was also observed in another study on neural stem cells incubated with Ag NPs [71]. Likewise, the uptake of TiO 2 NPs by glial cells was based on the mechanism of endocytosis.…”

Section: Cellular Uptakementioning

confidence: 92%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

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“…246 A number of reports reveals that coating over the silver nanoparticle reduces its toxicity. [247][248][249][250] In green synthesis, reduction and stabilization of the silver nanoparticles are achieved by the biocompatible material and hence the toxicity concern is reduced in most of the cases. Green synthesis using biopolymer i.e.…”

Section: Cytotoxicity Of Agnpsmentioning

confidence: 99%