Surface Design, Fabrication and Properties of Silicone Materials for Use in Tissue Engineering and Regenerative Medicine

Tambe, Nisarg; Cao, Jing; Xu, Ke; Willoughby, Julie A.

doi:10.1002/9781118938478.ch23

Cited by 1 publication

(1 citation statement)

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“…[6][7][8][9] However, most resorbable synthetic polymers used for tissue engineering scaffolds, including PLA, do not possess desirable surface properties necessary for scaffold-cell interaction and function. Surface engineering of these scaffolds 10 can therefore help promote their ability to support cells, promote proliferation, optimize cell-polymer interactions 11 and maintain the cell's functionality. 12 In the past decade, plasma surface treatments have generated considerable interest due their ability to functionalize and fine tune surface properties, 13 including the biocompatibility while maintaining the bulk properties constant.…”

Section: Introductionmentioning

confidence: 99%

Novel genipin‐collagen immobilization of polylactic acid (PLA) fibers for use as tissue engineering scaffolds

et al. 2014

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The material surface plays an important role in the case of biomaterials used as tissue engineering scaffolds. On exposure to a biological environment, extra cellular matrix (ECM) proteins are adsorbed non-specifically onto the surface and cells interact indirectly with the surface through the adsorbed proteins. Most synthetic polymeric biomaterials lack the desirable surface properties for cells as well as have poor cellular adhesion due to their hydrophobic nature. The main objective of this study was to harness surface functionalization technologies to fabricate scaffolds that would be biocompatible and support the adhesion and proliferation of fibroblast cells. The collagen was immobilized on the surface of functionalized PLA via a novel natural cross-linking molecule genipin which resulted in improved cell proliferation of human dermal fibroblasts as compared to the PLA surface coated with collagen without genipin. It is believed that genipin helps reduce steric problems between the functional groups and large protein molecules, and enables immobilized peptide to move more freely in a biological environment.

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