Surface engineering of biodegradable implants: emerging trends in bioactive ceramic coatings and mechanical treatments

Nilawar, Sagar; Uddin, Md. Sharif; Chatterjee, Kaushik

doi:10.1039/d1ma00733e

Cited by 29 publications

(20 citation statements)

References 222 publications

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“…These techniques including shot peening, ultrasound shot peening (USSP), laser shock peening (LSP), surface mechanical attrition treatment (SMAT), and ball burnishing, etc. are primarily designed to improve the tribological properties of the metallic part by inducing near-surface compressive residual stress [ 27 , 28 , 29 , 30 , 31 ]. However, the investigation of the corrosion resistance influenced by these strategies has also shown that these techniques can be exploited for the simultaneous improvement in the fatigue and degradation life of magnesium structures [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Surface Cleaning and Pre-treatmentmentioning

confidence: 99%

Chromate-Free Corrosion Protection Strategies for Magnesium Alloys—A Review: PART I—Pre-Treatment and Conversion Coating

et al. 2022

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Corrosion protection systems based on hexavalent chromium are traditionally perceived to be a panacea for many engineering metals including magnesium alloys. However, bans and strict application regulations attributed to environmental concerns and the carcinogenic nature of hexavalent chromium have driven a considerable amount of effort into developing safer and more environmentally friendly alternative techniques that provide the desired corrosion protection performance for magnesium and its alloys. Part I of this review series considers the various pre-treatment methods as the earliest step involved in the preparation of Mg surfaces for the purpose of further anti-corrosion treatments. The decisive effect of pre-treatment on the corrosion properties of both bare and coated magnesium is discussed. The second section of this review covers the fundamentals and performance of conventional and state-of-the-art conversion coating formulations including phosphate-based, rare-earth-based, vanadate, fluoride-based, and LDH. In addition, the advantages and challenges of each conversion coating formulation are discussed to accommodate the perspectives on their application and future development. Several auspicious corrosion protection performances have been reported as the outcome of extensive ongoing research dedicated to the development of conversion coatings, which can potentially replace hazardous chromium(VI)-based technologies in industries.

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Section: Surface Cleaning and Pre-treatmentmentioning

confidence: 99%

Chromate-Free Corrosion Protection Strategies for Magnesium Alloys—A Review: PART I—Pre-Treatment and Conversion Coating

et al. 2022

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“…15,16 Other ceramics, such as vanadium oxide, are reported to be toxic at high concentrations, 17 whereas europium oxide has been investigated as a proangiogenic agent mediated by increased ROS production. 18 In comparison, ceria has been known to have low cell toxicity along with ROS scavenging, osteogenic activity, and antibacterial potential.…”

Section: Introductionmentioning

confidence: 99%

“…Surface functionalization is a viable strategy to impart bioactivity to PLA scaffolds. 18,25 The goal of this work was to investigate the potential of redox-modulating ceria nanoparticles to promote stem cell osteogenesis and inhibit bacterial growth on 3D-printed scaffolds for bone tissue engineering. We prepared porous PLA scaffolds by FFF and established a strategy for surface functionalization with ceria.…”

Section: Introductionmentioning

confidence: 99%

“…Most of these efforts have focused on soft tissue regeneration, with a few studies related to hard tissues. There is some evidence that ceria supports osteogenic differentiation and bone matrix formation of human mesenchymal stem cells (hMSCs). , Other ceramics, such as vanadium oxide, are reported to be toxic at high concentrations, whereas europium oxide has been investigated as a proangiogenic agent mediated by increased ROS production . In comparison, ceria has been known to have low cell toxicity along with ROS scavenging, osteogenic activity, and antibacterial potential.…”

Section: Introductionmentioning

confidence: 99%

“…But PLA lacks bioactivity for promoting cell differentiation. Surface functionalization is a viable strategy to impart bioactivity to PLA scaffolds. , …”

Section: Introductionmentioning

confidence: 99%

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Surface Decoration of Redox-Modulating Nanoceria on 3D-Printed Tissue Scaffolds Promotes Stem Cell Osteogenesis and Attenuates Bacterial Colonization

Nilawar

Chatterjee

2021

Biomacromolecules

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Oxidative stress at the bone defect site delays the bone regeneration process. Increased level of reactive oxygen species (ROS) is the primary cause of oxidative stress at the damaged site. Bone tissue scaffolds that scavenge ROS offer a potential and yet unexplored route for faster bone healing. Cerium oxide (ceria) is known for its redox-modulating behavior. Threedimensional (3D)-printed porous scaffolds fabricated from degradable polymers provide a physical microenvironment but lack the bioactivity for tissue regeneration. In this work, porous poly(lactic acid) (PLA) scaffolds were prepared by 3D printing and modified with poly(ethylene imine) and citric acid to decorate with ceria nanoparticles. Scanning electron micrographs revealed a macroporous architecture decorated with ceria particles. The compressive modulus of 27 MPa makes them suitable for trabecular bone. The scaffolds supported human mesenchymal stem cell growth, confirming cytocompatibility. The ability to scavenge ROS confirmed that surface functionalization with ceria could reduce oxidative stress levels in the cells. Stem cell osteogenesis was enhanced after ceria decoration of the PLA scaffolds. Transcriptional profiling studied by sequencing revealed changes in the expression of genes associated with inflammation and cell−material interactions. The ceria-functionalized scaffolds show enhanced antibacterial activity against both Gram-negative and Gram-positive bacterial strains. These results demonstrate that surface decoration with nanoceria offers a viable route for enhancing the bioactivity of 3D-printed PLA scaffolds for bone tissue regeneration with ROS scavenging and antibacterial capability.

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Development of surface‐treated poly(lactic acid)/zinc oxide biocomposites for 3D printing in bone tissue engineering

Marega,

Klok,

Steffen

et al. 2024

J of Applied Polymer Sci

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The increase in bone fractures has been driving the development of materials for bone repair with better mechanical and biological properties. This work reports the development of poly (lactic acid) (PLA)‐zinc oxide (ZnO) biocomposites for 3D printing of scaffolds to be applied in bone tissue engineering. The ZnO surface was functionalized with maleic anhydride (ZnOMA) by applying radio frequency plasma treatment as an alternative to control the catalytic effects of ZnO on the degradation of the PLA during the molten state processing. PLA and ZnOMA powders were processed using a heated internal mixer and the resulted biocomposites were used to manufacture scaffolds by 3D printing. The scaffolds were characterized by their rheological, thermal, microstructural, mechanical, and biological properties. Compositions containing ZnOMA presented higher viscosities, evidencing the control of degradation by surface functionalization, and achieved an elastic modulus near 1 GPa, suitable for bone applications, unlike the untreated samples. In relation to cell functions, PLA‐ZnOMA scaffolds exhibited cell viabilities at 160%, compared to 50% for untreated samples and stimulated mesenchymal stem cells toward osteoblast. Therefore, ZnO's negative thermal degradation effect on PLA was successfully overcome using plasma functionalization, enabling the 3D printing of bioactive scaffolds with great potential for application in tissue engineering.

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Surface engineering of biodegradable implants: emerging trends in bioactive ceramic coatings and mechanical treatments

Abstract: Surface of an implant plays a key role in determining the performance as several events are associated with the surface. Modifying the surface with a bioactive coating or/and mechanical treatment can profoundly affect the success of the implant.

Cited by 29 publications

References 222 publications

Chromate-Free Corrosion Protection Strategies for Magnesium Alloys—A Review: PART I—Pre-Treatment and Conversion Coating

Chromate-Free Corrosion Protection Strategies for Magnesium Alloys—A Review: PART I—Pre-Treatment and Conversion Coating

Surface Decoration of Redox-Modulating Nanoceria on 3D-Printed Tissue Scaffolds Promotes Stem Cell Osteogenesis and Attenuates Bacterial Colonization

Development of surface‐treated poly(lactic acid)/zinc oxide biocomposites for 3D printing in bone tissue engineering

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