Surface‐Enhanced Raman Probes Based on Gold Nanomaterials for <i>in vivo</i> Diagnosis and Imaging

Wen, Changchun; Wang, Liping; Liu, Li; Shen, Xing‐Can; Chen, Hua

doi:10.1002/asia.202200014

Cited by 17 publications

(5 citation statements)

References 111 publications

(265 reference statements)

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“…In order to improve the biocompatibility of SERS probes, a SiO 2 or polymer protective layer is usually coated on the surface of the labeled nanoparticles [ 201 , 211 ]. One of the most common surface modification molecules is PEG, which can not only prevent excessive aggregation caused by surface charge of nanoparticles, but also confer increased stability within a variety of microenvironments [ 202 ].…”

Section: Biosensing Applications In Several Important Bio-fieldsmentioning

confidence: 99%

Recent development of surface-enhanced Raman scattering for biosensing

Lin

Peng

et al. 2023

J Nanobiotechnol

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Surface-Enhanced Raman Scattering (SERS) technology, as a powerful tool to identify molecular species by collecting molecular spectral signals at the single-molecule level, has achieved substantial progresses in the fields of environmental science, medical diagnosis, food safety, and biological analysis. As deepening research is delved into SERS sensing, more and more high-performance or multifunctional SERS substrate materials emerge, which are expected to push Raman sensing into more application fields. Especially in the field of biological analysis, intrinsic and extrinsic SERS sensing schemes have been widely used and explored due to their fast, sensitive and reliable advantages. Herein, recent developments of SERS substrates and their applications in biomolecular detection (SARS-CoV-2 virus, tumor etc.), biological imaging and pesticide detection are summarized. The SERS concepts (including its basic theory and sensing mechanism) and the important strategies (extending from nanomaterials with tunable shapes and nanostructures to surface bio-functionalization by modifying affinity groups or specific biomolecules) for improving SERS biosensing performance are comprehensively discussed. For data analysis and identification, the applications of machine learning methods and software acquisition sources in SERS biosensing and diagnosing are discussed in detail. In conclusion, the challenges and perspectives of SERS biosensing in the future are presented.

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Section: Biosensing Applications In Several Important Bio-fieldsmentioning

confidence: 99%

Recent development of surface-enhanced Raman scattering for biosensing

Lin

Peng

et al. 2023

J Nanobiotechnol

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“…Many studies have used gold nanoparticles (AuNPs) for therapeutic applications in cancer treatments [16] (Figure 1). High atomic number, relatively strong photoelectric absorption coefficient, good renal clearance, and biocompatibility are the features that make AuNPs a good, promising choice for use in radiotherapy [17,18]. Studies have often investigated the radiation sensitization and synergistic effects of AuNPs alone or in combination with other materials or treatment modalities.…”

Section: Gold-based Nanoparticlesmentioning

confidence: 99%

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

2023

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In recent years, there has been an increasing interest in using nanoparticles in the medical sciences. Today, metal nanoparticles have many applications in medicine for tumor visualization, drug delivery, and early diagnosis, with different modalities such as X-ray imaging, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), etc., and treatment with radiation. This paper reviews recent findings of recent metal nanotheranostics in medical imaging and therapy. The study offers some critical insights into using different types of metal nanoparticles in medicine for cancer detection and treatment purposes. The data of this review study were gathered from multiple scientific citation websites such as Google Scholar, PubMed, Scopus, and Web of Science up through the end of January 2023. In the literature, many metal nanoparticles are used for medical applications. However, due to their high abundance, low price, and high performance for visualization and treatment, nanoparticles such as gold, bismuth, tungsten, tantalum, ytterbium, gadolinium, silver, iron, platinum, and lead have been investigated in this review study. This paper has highlighted the importance of gold, gadolinium, and iron-based metal nanoparticles in different forms for tumor visualization and treatment in medical applications due to their ease of functionalization, low toxicity, and superior biocompatibility.

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“…Among these techniques, surface-enhanced Raman scattering (SERS) is widely employed to enhance the scattering signal by adsorbing Raman-active molecules onto metal substrates such as gold (Au) [19,20]. However, the exceptional chemical stability and resistance to degradation and metabolism of Au and other metal substrates raise potential biocompatibility issues [21,22]. In contrast to SERS, organic resonance-enhanced Raman scattering does not require a metal substrate [23].…”

Section: Introductionmentioning

confidence: 99%

A Visual Raman Nano−Delivery System Based on Thiophene Polymer for Microtumor Detection

Li,

Luo,

et al. 2024

Pharmaceutics

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A visual Raman nano-delivery system (NS) is a widely used technique for the visualization and diagnosis of tumors and various biological processes. Thiophene-based organic polymers exhibit excellent biocompatibility, making them promising candidates for development as a visual Raman NS. However, materials based on thiophene face limitations due to their absorption spectra not matching with NIR (near-infrared) excitation light, which makes it difficult to achieve enhanced Raman properties and also introduces potential fluorescence interference. In this study, we introduce a donor–acceptor (D-A)-structured thiophene-based polymer, PBDB-T. Due to the D-A molecular modulation, PBDB-T exhibits a narrow bandgap of Eg = 2.63 eV and a red-shifted absorption spectrum, with the absorption edge extending into the NIR region. Upon optimal excitation with 785 nm light, it achieves ultra-strong pre-resonant Raman enhancement while avoiding fluorescence interference. As an intrinsically sensitive visual Raman NS for in vivo imaging, the PBDB-T NS enables the diagnosis of microtumor regions with dimensions of 0.5 mm × 0.9 mm, and also successfully diagnoses deeper tumor tissues, with an in vivo circulation half-life of 14.5 h. This research unveils the potential application of PBDB-T as a NIR excited visual Raman NS for microtumor diagnosis, introducing a new platform for the advancement of “Visualized Drug Delivery Systems”. Moreover, the aforementioned platform enables the development of a more diverse range of targeted visual drug delivery methods, which can be tailored to specific regions.

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Surface‐Enhanced Raman Probes Based on Gold Nanomaterials for in vivo Diagnosis and Imaging

Cited by 17 publications

References 111 publications

Recent development of surface-enhanced Raman scattering for biosensing

Recent development of surface-enhanced Raman scattering for biosensing

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

A Visual Raman Nano−Delivery System Based on Thiophene Polymer for Microtumor Detection

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