Surface-enhanced Raman scattering (SERS)-active gold nanochains for multiplex detection and photodynamic therapy of cancer

Zhao, Linlin; Kim, Tae Hyun; Kim, Hae‐Won; Ahn, Jin‐Chul; Kim, So Yeon

doi:10.1016/j.actbio.2015.03.036

Cited by 33 publications

(21 citation statements)

References 46 publications

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“…In Fig. 2A, it is observed that two new peaks at 1564 and 1622 cm − 1 , attributed to the amide bond, appear in the PpIX-SH compared with the PpIX, and the characteristic peak of the PpIX-SH at 1988 cm − 1 , corresponding to the stretching vibration of -SH in cysteamine hydrochloride [51], is also observed. Clearly, this result demonstrates that a thiol group has been introduced into PpIX by the conjugation between the carboxyl group of PpIX and the amino group of cysteamine hydrochloride.…”

Section: Synthesis and Characterization Of Ptt/pdt Nanodrugsmentioning

confidence: 88%

“…S4. Although some aggregation occurs, the properties of PTT and PDT properties will not be affected [51].…”

Section: Synthesis and Characterization Of Ptt/pdt Nanodrugsmentioning

confidence: 99%

“…However, these methods have disadvantages in low stability or low sensitivity. Surface enhanced Raman scattering (SERS) imaging, a developing solution with high stability and sensitivity, high specificity and in situ detection, is becoming a good solution for phototherapy application [48][49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

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SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

Tang¹,

Xing²,

Tao³

et al. 2020

Preprint

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Background: Chemotherapy and radiotherapy are common methods of cancer treatment, but they are accompanied by serious side effects. Actually, many cancer cells have overexpression of folic acid (FA) receptor and by FA receptor-mediated endocytosis, anticancer drugs can be easily internalized into cancer cell, this will greatly improve the curative effect and decrease side effects. Along with the development of nanotechnology, phototherapy, owning advantages in tissue selectivity, process controlling, low toxicity and reproducible treatment, has become very promising, especially for photothermal therapy (PTT) and photodynamic therapy (PDT). Since both PTT and PDT involve the utilization of light energy, so they synergistic treatment should be a good solution by ingenious design. In this paper, based on surface enhanced Raman spectroscopy (SERS) imaging, we hope to construct a FA receptor-mediated PTT/PDT synergistic anticancer nanodrug (nanoprobe), and achieve the intracellular distribution information of the nanodrugs during cell apoptosis, and then elucidate PTT/PDT-induced cell apoptosis and synergistic efficiency.Results: FA receptor-mediated PTT/PDT synergistic anticancer nanodrugs with tracing function are prepared by the chemical synthesis and modification of gold nanorods (GNR), involving protoporphyrin IX (PpIX), 4-mecaptobenzoic acid (MBA), and FA. Based on SERS imaging, it is found that the FA receptor-mediated endocytosis can greatly facilitate the nanodrugs internalization, in which both the number and intracellular dispersion of the PpIX-GNR-MBA-FA nanodrugs are improved relative to the GNR-MBA or PpIX-GNR-MBA compositions, and then enhance the PTT/PDT-induced cell apoptosis.Conclusion: SERS imaging is very suitable for the phototherapy tracing due to its high sensitivity and stability. The FA receptor-mediated way can significantly facilitate nanodrugs internalization, PTT/PDT-induced cell apoptosis and synergistic efficiency. Importantly, this FA receptor-mediated SERS imaging based PTT/PDT synergistic treatment will provide a novel strategy for the design and application of anticancer phototherapy nanodrugs.

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Section: Synthesis and Characterization Of Ptt/pdt Nanodrugsmentioning

confidence: 88%

“…S4. Although some aggregation occurs, the properties of PTT and PDT properties will not be affected [51].…”

Section: Synthesis and Characterization Of Ptt/pdt Nanodrugsmentioning

confidence: 99%

See 1 more Smart Citation

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

Tang¹,

Xing²,

Tao³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Intra-tumorally injected antibody conjugated nanotags, specifically targeting the three biomarkers, exhibited maximum SERS signal at 6 h. These three SERS nano tags (SERS reporters) consist of cyanine 5 (Cy5) for (TGFbRII), malachite green isothiocyanate (MGIT) for CD44 and rhodamine6G (Rh6G) for EGFR, which are attached to gold nanoparticles (AuNPs) that were conjugated (with the mediation of polyethylene glycol (PEG)) to antibodies against these biomarkers. In their teranostic system, Zhao et al innovated a SERS-active gold nano chain that had a suitable structure for potential application in multiplex detection and photodynamic therapy (PDT) of cancer [75]. They assembled Raman reporter (2-naphthalenethiol (NPT)) and Pheo-SH attached AuNPs with a biocompatible polymer conjugate hyaluronic acid–hydrocaffeic acid (HA–HCA) and made a chain-like structure.…”

Section: Breast Cancermentioning

confidence: 99%

“…They assembled Raman reporter (2-naphthalenethiol (NPT)) and Pheo-SH attached AuNPs with a biocompatible polymer conjugate hyaluronic acid–hydrocaffeic acid (HA–HCA) and made a chain-like structure. Multiplex detections could be exploited to enhance the specificity of cancer detection if we target multiple specific biomarkers of a tumoral tissue [38]. Zheng et al evaluated the capability of SERS to identify different types of breast cancer from different sources.…”

Section: Breast Cancermentioning

confidence: 99%

Application of nanoparticles in cancer detection by Raman scattering based techniques

Ravanshad

Zadeh

Amani

et al. 2017

Nano Reviews & Experiments

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In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.

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A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer

Cao

et al. 2022

ChemMedChem

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Novel nanocomposites were constructed through encapsulation of Au nanoparticles and Ru nanoparticles into dendritic mesoporous silica (DMSN-Au-Ru NPs). These exhibit improved effects due to a cascade catalytic ability for the synergistic therapy of cancer. Au nanoparticles with glucose oxidase-like properties were found to catalyze the oxidation of glucose to produce H 2 O 2 , while Ru nanoparticles could decompose H 2 O 2 and produce toxic 1 O 2 for improved photodynamic therapy (PDT). In addition, the nanocomposites were found to have good photothermal performance under irradiation by nearinfrared (NIR) light. Both in vitro and in vivo experiments show that the nanocomposites have good therapeutic effects due to the cascade catalytic effect and synergistic effect. These findings provide an effective way to design a new generation of nanodrugs for highly efficient cancer treatment.

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Surface-enhanced Raman scattering (SERS)-active gold nanochains for multiplex detection and photodynamic therapy of cancer

Cited by 33 publications

References 46 publications

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

SERS imaging elucidates the folate receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs-induced cell apoptosis

Application of nanoparticles in cancer detection by Raman scattering based techniques

A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer

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