Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Xu, Cai-Xia; Song, Pei; Yu, Zhou; Wang, Ya-Hao

doi:10.1039/d3an01466e

Cited by 2 publications

(1 citation statement)

References 107 publications

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“…Quantitative analysis is crucial to ensuring the efficacy and safety of herbal medicine [ 1 ]. Technological advancements have led to the use of various advanced instruments for the quality control of herbal medicine, including chromatographs [ 2 ], surface-enhanced Raman spectroscopy [ 3 ], capillary electrophoresis [ 4 ], near-infrared spectroscopy [ 5 ], mass spectrometry imaging [ 6 ], hyperspectral imaging [ 7 ], nuclear magnetic resonance (NMR) [ 8 ], microfluidics [ 9 ], etc. Among these, liquid chromatography with ultraviolet/mass spectrometry (LC-UV/MS) is the most widely used and highly accepted method.…”

Section: Introductionmentioning

confidence: 99%

Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling Capsule

Huang,

Xue,

Liang

et al. 2024

Molecules

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Herbal medicine has been widely valued because of its remarkable efficacy and minimal side effects. The quantitative analysis of herbal medicines is essential to ensure their safety and efficacy. The simultaneous detection of multiple quality markers (Q-markers) has emerged as an important approach and trend in herbal medicine quality control. In recent years, non-targeted screening has become an effective strategy for the discovery and identification of unknown compounds. This study developed a non-targeted screening and quantitative analysis strategy to discover, identify and quantify the multiple components that truly represent the efficacy of Wuling capsule. Within this strategy, 18 types of flavonoids were tentatively discovered and identified from Wuling capsule by analyzing mass cleavage pathways, the precise molecular weights of compounds, and comparing the data with a database. Ten types of flavonoids were determined after the comparison of the standards. Additionally, following the evaluation of the regression equation, linear range, limit of detection (LOD), limit of quantitation (LOQ), precision, repeatability, and recovery of the proposed quantitative method, six flavonoids were quantified. This method successfully screened, identified, and quantified the potential active components in Wuling capsule, providing insights for improving the quality control standards in other herbal medicines.

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Section: Introductionmentioning

confidence: 99%

Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling Capsule

Huang,

Xue,

Liang

et al. 2024

Molecules

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Raman spectroscopy – a visit to the literature on plant, food, and agricultural studies

Lemes

2024

J Sci Food Agric

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Raman spectroscopy, a fast, non‐invasive, and label‐free optical technique, has significantly advanced plant and food studies and precision agriculture by providing detailed molecular insights into biological tissues. Utilizing the Raman scattering effect generates unique spectral fingerprints that comprehensively analyze tissue composition, concentration, and molecular structure. These fingerprints are obtained without chemical additives or extensive sample preparation, making Raman spectroscopy particularly suitable for in‐field applications. Technological enhancements such as surface‐enhanced Raman scattering, Fourier‐transform‐Raman spectroscopy, and chemometrics have increased Raman spectroscopy sensitivity and precision. These and other advancements enable real‐time monitoring of compound translocation within plants and improve the detection of chemical and biological contaminants, essential for food safety and crop optimization. Integrating Raman spectroscopy into agronomic practices is transformative and marks a shift toward more sustainable farming activities. It assesses crop quality – as well as the quality of the food that originated from crop production – early plant stress detection and supports targeted breeding programs. Advanced data processing techniques and machine learning integration efficiently handle complex spectral data, providing a dynamic and detailed view of food conditions and plant health under varying environmental and biological stresses. As global agriculture faces the dual challenges of increasing productivity and sustainability, Raman spectroscopy stands out as an indispensable tool, enhancing farming practices' precision, food safety, and environmental compatibility. This review is intended to select and briefly comment on outstanding literature to give researchers, students, and consultants a reference for works of literature in Raman spectroscopy mainly focused on plant, food, and agronomic sciences. © 2024 Society of Chemical Industry.

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Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Abstract: Surface-enhanced Raman spectroscopy has become a promising analytical method for raw material identification, bioactive component detection, adulterant characterization, and contaminant detection of Chinese herbal medicines.

Cited by 2 publications

References 107 publications

Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling Capsule

Development of a Non-Target Screening and Quantitative Analysis Strategy Based on UPLC-Q-TOF/MS and UPLC-QQQ/MS to Improve the Quality Control of Wuling Capsule

Raman spectroscopy – a visit to the literature on plant, food, and agricultural studies

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