Surface-Enhanced Raman Spectroscopy on Selectively Adsorbed Plasmonic Nanostructures Using Polar Surface Arrays

Wang, Zunhao; Liu, Zhaowei; Dempwolf, Wibke; Molle, Julia; Kanehira, Yuya; Kogikoski, Sergio; Etzkorn, Markus; Bald, Ilko; Stosch, Rainer; Wundrack, Stefan

doi:10.1021/acsanm.3c01776

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…Bottom-up assembly based on DNA origami can also be combined with top-down lithography [70]. Martynenko et al demonstrated a method for the precisely targeted placement of various shapes of DNA origami on the micrometer to millimeter scale [71].…”

Section: D Arraysmentioning

confidence: 99%

DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications

Xie,

Jiang,

Chao

2023

Sensors

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Gold nanoparticles (Au NPs) have become one of the building blocks for superior assembly and device fabrication due to the intrinsic, tunable physical properties of nanoparticles. With the development of DNA nanotechnology, gold nanoparticles are organized in a highly precise and controllable way under the mediation of DNA, achieving programmability and specificity unmatched by other ligands. The successful construction of abundant gold nanoparticle assembly structures has also given rise to the fabrication of a wide range of sensors, which has greatly contributed to the development of the sensing field. In this review, we focus on the progress in the DNA-mediated assembly of Au NPs and their application in sensing in the past five years. Firstly, we highlight the strategies used for the orderly organization of Au NPs with DNA. Then, we describe the DNA-based assembly of Au NPs for sensing applications and representative research therein. Finally, we summarize the advantages of DNA nanotechnology in assembling complex Au NPs and outline the challenges and limitations in constructing complex gold nanoparticle assembly structures with tailored functionalities.

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Section: D Arraysmentioning

confidence: 99%

DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications

Xie,

Jiang,

Chao

2023

Sensors

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Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding

Liu,

Wang,

Guckel

et al. 2024

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DNA origami is a flexible platform for the precise organization of nano‐objects, enabling numerous applications from biomedicine to nano‐photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top‐down lithography with bottom‐up DNA origami techniques to control folding of the DNA origami with the adsorption on pre‐patterned surfaces. Using this approach, tunable plasmonic dimer nano‐arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self‐organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center‐to‐center distance of the AuNPs dimers on the origami template. To demonstrate this technique's efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami‐based plasmonic nanostructures for many applications.

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Novel analysis tool for the distance of gold dimers controlled by the DNA strand length on the DNA origami

Guckel,

Liu,

Wang

et al. 2024

Journal of Microscopy

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Metallic nanoparticle dimers have been used to enhance the excitation rate of single‐quantum emitters. The interparticle distance (d) of the dimers has a crucial influence on the signal enhancement. Therefore, precise control of d is desired for optimal performance. However, statistical analysis of d has been often restricted to a small number of dimers due to the lack of reliable automatic software tools.For this reason, we developed a novel analysis tool for automatic dimer analysis. Our approach combines particle detection by circle Hough transformation (CHT) with custom classification routines optimised for distinct types of particles. We applied our tool to scanning electron microscopy (SEM) images and achieved great agreement in dimer detection, reaching an agreement of around 97% between automatic analysis and manual inspection for more than 3000 metallic nanoparticle dimers on DNA origami controlled by a combination of multiple DNA strands.Our study revealed the effects of the strand length (L) on the distribution of d. Based on geometric consideration, we expected a strong correlation between L and the standard deviation (σ) of d. We could verify this correlation by characterising four dimer designs with different L while analysing more than 1000 dimers per specimen.

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Surface-Enhanced Raman Spectroscopy on Selectively Adsorbed Plasmonic Nanostructures Using Polar Surface Arrays

Cited by 3 publications

References 53 publications

DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications

DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications

Controlling Nanoparticle Distance by On‐Surface DNA‐Origami Folding

Novel analysis tool for the distance of gold dimers controlled by the DNA strand length on the DNA origami

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