Surface Flavonoids in <i>Catalpa Ovata, Greyia Sutherlandii</i> and <i>Paulownia Tomentosa</i>

Wollenweber, Eckhard; Wehde, Rüdiger; Christ, Matthias; Dörr, Marion

doi:10.1177/1934578x0800300810

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…In a recent paper, reporting on exudate flavonoids occurring on green fruits of Catalpa ovata and Paulownia tomentosa [6], it was suggested that more attention should be paid to the localization of flavonoids on (unripe) fruits, which is underlined by our present results. Current results also indicate that organ specific diversification of exudate flavonoid profiles may occur occasionally.…”

Section: No 2 211 -212supporting

confidence: 63%

Exudate Flavonoids of Some Juglandaceae

Wollenweber

Dörr

2009

Natural Product Communications

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Six species of Juglandaceae have been checked for the occurrence of flavonoid aglycones on their leaf and fruit surfaces. Except for one, they exhibit flavonols, mostly methyl ethers of kaempferol and quercetin, including 6- O-substituted derivatives. Apigenin and acacetin are the only flavones found so far. Flavonoids accumulated on leaves are different from those excreted on green fruits. It has become evident that in future studies greater attention must be paid to the localization of flavonoid aglycones in different plant organs.

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Section: No 2 211 -212supporting

confidence: 63%

Exudate Flavonoids of Some Juglandaceae

Wollenweber

Dörr

2009

Natural Product Communications

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“…Leaves, green immature fruit (Wollenweber et al 2008) Antimicrobial activity, poor antifungal effect (Omosa et al 2014); low antimicrobial activity, low toxicity against human lymphocytes and monocytes, antioxidant/antiinflammatory activity (Martini et al 2004;Pelzer et al 1998); low affinity to acetylcholinesterase (Remya et al 2012); low inhibitory effect on NO production in RAW264.7 cells (Sudsai et al 2013); no activity against HSV-1, low toxicity against Vero cells (Tian et al 2009); no antioxidant activity (Takamatsu et al 2003); no trypanocidal activity (Grael et al 2000); activity against lipid peroxidation in rat liver microsomes (Yun et al 2000); cytotoxicity against TK-10, MCF-7 and UACC-62 cells (Lopez-Lazaro et al 2000); no inhibition of glycolysis in various tumor cells (Suolinna et al 1975 ,4 0 -Trimethylquercetin (7) Thrombin inhibition (Shi et al 2012); inhibition of IL-4 synthesis in basophils (Hirano et al 2006); weak trypanocidal activity (Jordao et al 2004); weak inhibition of NO production in LPS-activated mouse peritoneal macrophages (Matsuda et al 2003); weak inhibition of degranulation of RBL-2H3 cells (Mastuda et al 2002);…”

Section: /K ?mentioning

confidence: 99%

Phytochemical profile of Paulownia tomentosa (Thunb). Steud.

Schneiderová

Šmejkal

2014

Phytochem Rev

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Paulownia tomentosa, a member of the plant family Paulowniaceae and a rich source of biologically active secondary metabolites, is traditionally used in Chinese herbal medicine. Flavonoids, lignans, phenolic glycosides, quinones, terpenoids, glycerides, phenolic acids, and miscellaneous other compounds have been isolated from different parts of P. tomentosa plant. Recent interest in this species has focused on isolating and identifying of prenylated flavonoids, that exhibit potent antioxidant, antibacterial, and antiphlogistic activities and inhibit severe acute respiratory syndrome coronavirus papain-like protease. They show cytotoxic activity against various human cancer cell lines and inhibit the effects of human cholinesterase, butyrylcholinesterase, and bacterial neuraminidases. Most of the compounds considered here have never been isolated from any other species of plant. This review summarizes the information about the isolated compounds that are active, their bioactivities, and the structure-activity relationships that have been worked out for them. major flavonoid of citrus, activity reviewed by Khan and Zill-E-Huma (2014) 114 R1= R2= R3=R4= H 121 R1= R2=R3=R4 = H 115 R1= OH (6S), R2= R3=R4= H 122 R1= OH (6S), R2=R3= R4= H 116 R1= R3=R4= H, R2= OH (7R) 123 R1= R3=R4= H, R2= OH (7R) 117 R1= R2=R4= H, R3= OH (8R) 124 R1= R2=R4= H, R3= OH (8R) 118 R1= R2=R3= H, R4= OH (9R) 125 R1= R2=R3= H, R4= OH (9R) 119 R1= R3=R4= H, R2= OAc (7R) 126 R1= R2=R4= H, R3= OAc (8R) 120 R1= R2=R4= H, R3= OAc (8R) 127 R1= R2=R3= H, R4= OAc (9R)

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“…NMR Spectroscopic Data (400 MHz, MeOD) for Tomentodiplacones L (1) and M (2) and Tomentodiplacol B(3) …”

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confidence: 99%

“…In particular, C -geranyl flavonoids obtained from P. tomentosa fruits have become the focus of phytochemical research because of their wide spectrum of biological activities. So far, 38 geranylated and two prenylated flavonoids have been isolated from P. tomentosa . − Twenty-six of these C -geranyl flavonoids possess a side-chain modified by oxidation, reduction, or cyclization. The significant bioactivities of these geranylated flavonoids have been investigated mainly using antibacterial, cytotoxic, antiphlogistic, or antioxidant assays. ,− ,− …”

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confidence: 99%

C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production

Hanáková¹,

Hošek²,

Babula³

et al. 2015

J. Nat. Prod.

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Eleven new C-geranylated flavonoids, tomentodiplacones L, M, and N (1, 2, 10), tomentodiplacol B (3), 3',4'-O-dimethyl-5'-hydroxydiplacone (4), mimulones F, G, and H (5, 6, 7), paulowniones A (8) and B (9), tomentone (11), and 3',4',5'-trimethoxyflavanone (12), together with 11 known flavonoids (13-23), were isolated from fruits of Paulownia tomentosa. The structures of the compounds isolated were determined by spectroscopic data interpretation. The ability of compounds 1-23, together with the nonprenylated flavanones eriodictyol (24) and naringenin (25), to reduce the production of the pro-inflammatory cytokine TNF-α in THP-1 cells after bacterial lipopolysaccharide stimulation was evaluated using an in vitro screening test. The preliminary structure-activity relationships of these derivatives were also studied, and the correlation of their TNF-α inhibitory activity with their lipophilicity was investigated. The mechanism of action of compounds with significant antiphlogistic potential (4, 7, 10, 14, 22) was investigated. These compounds reduced both the secretion of TNF-α and the level of its corresponding mRNA. Compounds 4, 7, 10, 14, and 22 inhibited the nuclear translocation of NF-κB, which controls the expression of TNF-α, by blocking the degradation of IκB.

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Surface Flavonoids in Catalpa Ovata, Greyia Sutherlandii and Paulownia Tomentosa

Cited by 3 publications

References 18 publications

Exudate Flavonoids of Some Juglandaceae

Exudate Flavonoids of Some Juglandaceae

Phytochemical profile of Paulownia tomentosa (Thunb). Steud.

C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production

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