Surface functionalization of titanium implants with chitosan-catechol conjugate for suppression of ROS-induced cells damage and improvement of osteogenesis

Chen, Weizhen; Shen, Xinkun; Hu, Yan; Xu, Kui; Ran, Qichun; Yu, Yu; Dai, Liangliang; Yuan, Zhangfu; Huang, Ling; Shen, Tingting; Cai, Kaiyong

doi:10.1016/j.biomaterials.2016.10.055

Cited by 190 publications

(110 citation statements)

References 57 publications

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“…It was found that the coatings obtained by both LbL methods exhibit higher hydrophilicity than the glass control. These results can be related by the presence of the catechol groups in modified CHT and HA, since an hydrophilicity increase of the glass substrate after deposition of multilayer films containing catechol‐modified HA was previously reported (Chen et al, ; Hong et al, ; Neto et al, ; Zhang, Li, Yuan, Cui, & Yang, ). Particularly, in a previous work developed by our group (Neto et al, ), [CHT/HA‐C] 10 dip‐coated films showed lower WCA values (around 73°) compared to [CHT/HA] 10 dip‐coated films (around 77°), using glass as substrate.…”

Section: Discussionsupporting

confidence: 60%

“…Particularly, the increase of the implant surface roughness has been used to enhance the bonding strength of living tissues, due to the higher specific surface area of the implant in the tissue‐implant contact (Krishna Alla et al, ). Moreover, for Ti substrates, Chen et al already demonstrated that multilayered coatings with higher surface roughness promoted improved osteoblasts adhesion, proliferation and differentiation (Chen et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates

et al. 2019

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Layer‐by‐layer films based on chitosan and hyaluronic acid were produced by dip‐ and spin‐coating techniques onto glass, 316L stainless steel and titanium. These natural polymers were modified with catechol groups, in order to build coatings with improved adhesive properties. Polymeric coatings were exclusively composed by both modified polymers whereas the multifunctional coatings combined an inorganic phase of bioactive glass nanoparticles with the polymeric layers to confer bioactivity. Ultraviolet–visible spectroscopy demonstrated that both polymers were successfully synthesized. Fourier transform infrared imaging was used as an innovative way to analyze the layer interdiffusion in these coatings. Their morphology was analyzed by scanning electron microscopy and atomic force microscopy, and their wettability was evaluated by water contact angle measurements. Major differences were found in the structure and surface properties of the coatings assembled either by dip‐ or spin‐coating. The spin‐coated films onto glass were smoother, with a more homogeneous structure and lower interdiffusion of polyelectrolytes layers, when compared with the dip‐coated ones. Furthermore, it was concluded that the intrinsic surface roughness of stainless steel and titanium substrates had great influence on the surface morphology and wettability of the coatings obtained from both layer‐by‐layer methodologies.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates

et al. 2019

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“…Oxidative stress induced by ROS overproduction hinders bone healing at the interface between the bone and implant because it adversely affects the cell growth on the implant surface but large numbers of ROS would inevitably be generated when the cells are in contact with a biomaterial surface such as titanium, or as a result of complex reactions during the surgical procedure 40–43 . To decrease the intracellular ROS production, although the administration of pharmaceutical antioxidants can be considered, conventional methods of drug administration to reduce oxidative stress-related defences face many challenges, such as the targeting of the bone repair cells and the cytotoxicity of antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Overcoming the biological aging of titanium using a wet storage method after ultraviolet treatment

Choi

Jeong

Yul

et al. 2017

Sci Rep

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We evaluated whether the biological activity of the surface of titanium, when stored in an aqueous solution after ultraviolet (UV) treatment, is comparable to that of the surface immediately after UV treatment. We subjected Grade IV titanium discs with machined surfaces to UV radiation for 15 min and then tested them immediately and after storage for 28 days, with and without distilled H 2 O (dH 2 O). We evaluated the surface characteristics using surface profiling, contact angle analysis, X-ray photoelectron spectroscopy, and in terms of the surface zeta-potential. We determined the level of biological activity by analysing albumin adsorption, MC3T3-E1 and human mesenchymal cell adhesion and cytoskeleton development, as well as the production of intracellular reactive oxygen species between groups. The surface characteristics produced by the UV irradiation were maintained in dH 2 O for 28 days. We found that titanium stored in dH 2 O for 28 days after UV treatment exhibited enhanced protein adsorption, cell attachment, and cytoskeleton development. Titanium stored in dH 2 O for 28 days after UV irradiation exhibited a lower level of oxidative stress, comparable to that of the titanium immediately after UV treatment. UV treatment combined with wet storage can be used as a means of overcoming the biological aging of titanium.

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“…To develop such a functional implant, surface modification is an effective approach. Recently, much research efforts on Ti surface modification, such as topographical modification and immobilization of bioactive molecules, have been carried out to enhance the osseointegration and antibacterial properties of the Ti materials . In general, Ti based implant materials with nanorod topologic structure exhibit inherent surface advantages thanks to their high surface area, controllable dimensions, and universal drug delivery capacity .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Chitosan‐18β‐Glycyrrhetinic Acid Modified Titanium Implants with Nanorod Arrays for Suppression of Osteosarcoma Growth and Improvement of Osteoblasts Activity

Zhang

Cheng

Gong

et al. 2017

Adv Funct Materials

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Surgery has been combined with chemotherapy to treat osteosarcoma. However, the recovery rate of osteosarcoma patients is still low. To prevent post-operative recurrence of the osteosarcoma, developing an alternative biomaterial is essential. 18β-Glycyrrhetinic acid (GA) has shown potential anticancer activity in various malignancies. Here it is proposed that GA can induce osteosarcoma cell apoptosis, and a polydopamine-mediated titanium oxide nanorod (TiO 2 NR) surface is functionalized by covalently grafting the chitosan-18β-glycyrrhetinic acid conjugate (CS-GA). In vitro and in vivo biological tests indicate that the CS-GA modified surface shows significant antiproliferation and apoptosis in osteosarcoma cells (MG63). Additionally, this modified surface with nanoarray structure stimulation and chitosan supplementation significantly promotes osteoblast (MC3T3-E1) adhesion and proliferation in vitro. This dual-functional, Ti-based implant with balanced antitumor and biocompatibility properties represents an effective strategy for the surgical treatment of osteosarcoma.

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Surface functionalization of titanium implants with chitosan-catechol conjugate for suppression of ROS-induced cells damage and improvement of osteogenesis

Cited by 190 publications

References 57 publications

Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates

Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates

Overcoming the biological aging of titanium using a wet storage method after ultraviolet treatment

Fabrication of Chitosan‐18β‐Glycyrrhetinic Acid Modified Titanium Implants with Nanorod Arrays for Suppression of Osteosarcoma Growth and Improvement of Osteoblasts Activity

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