Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis

Saifullah, Salim; Ali, Imdad; Kawish, Muhammad; El-Shabasy, Rehan M.; Chen, Lei; El‐Seedi, Hesham R.

doi:10.1016/b978-0-12-816960-5.00012-4

Cited by 11 publications

(4 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two main factors that need to be considered in the usage of MNPs in vivo include size and surface modification. MNPs possess huge surface area that can be surface functionalised with a huge quantity of functional groups for crosslinking to tumour-targeting ligands, diagnostic imaging, or therapeutic agent delivery [137]. The diameters of MNPs primarily affect their performance in vivo, even in the absence of tumour-targeting surface ligands.…”

Section: In Vivo Applicationsmentioning

confidence: 99%

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

et al. 2020

View full text Add to dashboard Cite

Nanotechnology has gained much attention for its potential application in medical science. Iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications. In particular, magnetite (Fe3O4) nanoparticles are widely applied due to their biocompatibility, high magnetic susceptibility, chemical stability, innocuousness, high saturation magnetisation, and inexpensiveness. Magnetite (Fe3O4) exhibits superparamagnetism as its size shrinks in the single-domain region to around 20 nm, which is an essential property for use in biomedical applications. In this review, the application of magnetite nanoparticles (MNPs) in the biomedical field based on different synthesis approaches and various surface functionalisation materials was discussed. Firstly, a brief introduction on the MNP properties, such as physical, thermal, magnetic, and optical properties, is provided. Considering that the surface chemistry of MNPs plays an important role in the practical implementation of in vitro and in vivo applications, this review then focuses on several predominant synthesis methods and variations in the synthesis parameters of MNPs. The encapsulation of MNPs with organic and inorganic materials is also discussed. Finally, the most common in vivo and in vitro applications in the biomedical world are elucidated. This review aims to deliver concise information to new researchers in this field, guide them in selecting appropriate synthesis techniques for MNPs, and to enhance the surface chemistry of MNPs for their interests.

show abstract

Section: In Vivo Applicationsmentioning

confidence: 99%

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Other organic compounds used in functionalization such as octadecyl trichlorosilane, alkylbenzene sulfonate, poly(vinyl alcohol), poly(ethyleneimine), poly(acrylic acid) and poly(methyl methacrylate are also reported to cause pollution in soil. [100] Therefore, surface functionalization of MNPs using organic compounds is less preferred.…”

Section: Surface Functionalization Of Mnpsmentioning

confidence: 99%

The Potential of Fe‐Based Magnetic Nanomaterials for the Agriculture Sector

et al. 2022

View full text Add to dashboard Cite

Iron‐based magnetic nanoparticles (MNPs) have been studied extensively for the past few decades. They have been applied in various applications, particularly in the biomedical sector. Due to their excellent physical and chemical properties, they have also been used widely in the agricultural sector. MNPs can be synthesized inexpensively and applied in large scale agricultural activities. This paper highlights the applications of iron‐based MNPs in the agricultural sector mainly as antimicrobial agents, plant growth promoters, site‐targeted delivery agents, nanosensors, detection and remediation for pesticide residue. Furthermore, the toxicity and transport of iron‐based MNPs in the soil‐plant system are also elucidated. These aspects have to be well‐understood before MNPs can be fully implemented effectively this pin the agricultural sector. Lastly, a hybrid nanomaterial, which is consisted of iron and magnesium oxide (MgO) nanoparticles (NPs), is proposed. This hybrid nanomaterial is expected to overcome the shortcomings of iron‐based MNPs.

show abstract

“…In magnetic hyperthermia treatment, the activation of magnetic NPs by AMFs (alternating magnetic field) will remotely induce local heat, stimulating a temperature rise in the location of tumoral cells in targeted organs and tissues. To increase this technique’s efficiency, the magnetic NPs have to be systematically coated and functionalized to specifically target the desired area inside the body [ 110 ].…”

Section: Biomedical Applications Of Npsmentioning

confidence: 99%

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review

et al. 2023

View full text Add to dashboard Cite

Rapidly growing interest in using nanoparticles (NPs) for biomedical applications has increased concerns about their safety and toxicity. In comparison with bulk materials, NPs are more chemically active and toxic due to the greater surface area and small size. Understanding the NPs’ mechanism of toxicity, together with the factors influencing their behavior in biological environments, can help researchers to design NPs with reduced side effects and improved performance. After overviewing the classification and properties of NPs, this review article discusses their biomedical applications in molecular imaging and cell therapy, gene transfer, tissue engineering, targeted drug delivery, Anti-SARS-CoV-2 vaccines, cancer treatment, wound healing, and anti-bacterial applications. There are different mechanisms of toxicity of NPs, and their toxicity and behaviors depend on various factors, which are elaborated on in this article. More specifically, the mechanism of toxicity and their interactions with living components are discussed by considering the impact of different physiochemical parameters such as size, shape, structure, agglomeration state, surface charge, wettability, dose, and substance type. The toxicity of polymeric, silica-based, carbon-based, and metallic-based NPs (including plasmonic alloy NPs) have been considered separately.

show abstract

Surface functionalized magnetic nanoparticles for targeted cancer therapy and diagnosis

Cited by 11 publications

References 77 publications

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation

The Potential of Fe‐Based Magnetic Nanomaterials for the Agriculture Sector

Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review

Contact Info

Product

Resources

About