2024
DOI: 10.1002/adma.202309860
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Surface‐Functionalized Microgels as Artificial Antigen‐Presenting Cells to Regulate Expansion of T Cells

Junzhe Lou,
Charlotte Meyer,
Einat B. Vitner
et al.

Abstract: Artificial antigen‐presenting cells (aAPCs) are currently used to manufacture T cells for adoptive therapy in cancer treatment, but a readily tunable and modular system could enable both rapid T cell expansion and control over T cell phenotype. Here, we show that microgels with tailored surface biochemical properties can serve as aAPCs to mediate T cell activation and expansion. Surface functionalization of microgels was achieved via layer‐by‐layer coating using oppositely charged polymers, forming a thin but … Show more

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