Surface-initiated controlled radical polymerization enhanced DNA biosensing

Bilgic, Tugba; Klok, Harm‐Anton

doi:10.1016/j.eurpolymj.2014.07.037

Cited by 28 publications

(20 citation statements)

References 92 publications

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“…Ap olymerb rush system comprisesaforest of polymer chains tethered at some pointi nt he chain to as urface or substrate [116][117][118][119][120][121][122][123][124][125][126]. At low graftingd ensity,p olymer chains prefer to interact with themselves, adapting am ushroom like structure.A st he density increases,t he brushes begin stretching awayf rom the surface to reduce unfavorablei nteractions with neighboring chains, thus leading to al oss of entropy.…”

Section: Electrografting and Polymerb Rush Modifies Surfaces On Carbomentioning

confidence: 99%

“…Surface-initiated polymerization from covalently immobilized initiators has been shown to be ap owerful methodt oa chieve ah igh degree of control over the func-tionality,d ensity,a nd thickness of grafted materials [116][117][118][119][120][121][122][123][124][125][126].C ontrolled radical polymerizations,p articularly atom transfer radical polymerization (ATRP), are among the most-utilized methods to achieve surface initiated polymer brushes as they providee xcellent control over the polymers molecular weight, polydispersity,a nd composition, and are often experimentally straightforwardt o perform. Thes ubstrate is first modified with initiatorbearingm onolayer.…”

Section: Special Issuementioning

confidence: 99%

“…(Adapted with permission from[126];C opyright 2015 Elsevier). (Adapted with permission from[126];C opyright 2015 Elsevier).…”

mentioning

confidence: 99%

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Electrografting and Controlled Surface Functionalization of Carbon Based Surfaces for Electroanalysis

Randriamahazaka

Ghilane

2015

Electroanalysis

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The basic concepts of electrografting on carbon surfaces are reviewed with the emphasis on the prospects of achieving robust, well‐defined compositions and structures of electrode interfaces. The surface functionalization allows tuning the interfacial properties which play an important role in various electrochemical applications, such as sensors and biosensors. Covalent attachment of organic compounds can be achieved by means of the electrochemical reduction of diazonium salts, and oxidation of amine or carboxylate. This review also demonstrates that the electrografting followed by a post‐functionalization is an interesting approach in the designs of well‐defined interface for electrochemical (bio)sensing.

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Section: Electrografting and Polymerb Rush Modifies Surfaces On Carbomentioning

confidence: 99%

Section: Special Issuementioning

confidence: 99%

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Electrografting and Controlled Surface Functionalization of Carbon Based Surfaces for Electroanalysis

Randriamahazaka

Ghilane

2015

Electroanalysis

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“…Polymers, including synthetic polymers, semi-synthetic polymers and biopolymers, have been demonstrated as a valuable tool for tuning the physicochemical properties of a surface [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Polymer modified substrates have been extensively applied in various fields such as biomedicine, food safety, environment protection and microelectronics, because the polymers with high molecular weight provide multiple options for the immobilization of bioactive molecules with diverse functionalities and various labeling probes suitable for different detection principles [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. In the presence of properly selected reactive groups, including hydroxyl, carboxyl, aldehyde and amine on polymer chains, bioactive compounds can be easily immobilized on the polymer surfaces through covalent reactions and non-covalent interactions.…”

Section: Introductionmentioning

confidence: 99%

The Bioanalytical and Biomedical Applications of Polymer Modified Substrates

Sun

2022

Polymers

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Polymers with different structures and morphology have been extensively used to construct functionalized surfaces for a wide range of applications because the physicochemical properties of polymers can be finely adjusted by their molecular weights, polydispersity and configurations, as well as the chemical structures and natures of monomers. In particular, the specific functions of polymers can be easily achieved at post-synthesis by the attachment of different kinds of active molecules such as recognition ligand, peptides, aptamers and antibodies. In this review, the recent advances in the bioanalytical and biomedical applications of polymer modified substrates were summarized with subsections on functionalization using branched polymers, polymer brushes and polymer hydrogels. The review focuses on their applications as biosensors with excellent analytical performance and/or as nonfouling surfaces with efficient antibacterial activity. Finally, we discuss the perspectives and future directions of polymer modified substrates in the development of biodevices for the diagnosis, treatment and prevention of diseases.

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“…12 Controlled radical polymerization methods (CRP), such as atom transfer radical polymerization (ATRP), nitroxidemediated polymerization (NMP), reversible addition fragmentation chain transfer (RAFT) and macromolecular design via the interchange of xanthates (MADIX) polymerizations have become key tools for the polymerization of a wide range of conjugated monomers to get well dened polymers with predetermined molecular weight, narrow molecular weight distribution, and high degree of chain end functionality. [15][16][17][18][19][20][21][22] However, CRP for unconjugated monomers like N-vinylpyrrolidone (NVP) and NVCL are challenging due to the less activated vinyl groups. In recent years the synthesis of well-dened polymers of these unconjugated monomers via CRP is also getting more successful.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive polymer coated gold nanoparticles: from MADIX/RAFT copolymerization of N-vinylpyrrolidone and N-vinylcaprolactam to salt and temperature induced nanoparticle aggregation

et al. 2015

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In the present contribution, we report the MADIX/RAFT polymerization for the synthesis of thermoresponsive homo and statistical copolymers of N-vinylcaprolactam (NVCL) and N-vinylpyrrolidone (NVP). The conditions for the polymerization of NVP were optimized using an automated parallel synthesizer and these optimal conditions were applied for preparing copolymers with systematical variation in composition. The cloud point temperatures (T-CP's) of aqueous solutions of PNVCL and P(NVCL-stat-NVP)'s (CP1-CP5) were found to be tuneable between 40 degrees C and >95 degrees C at 5 mg mL(-1). Next, stable colloidal solutions of AuNPs coated with PNVCL and CP1-CP5 were obtained via an exchange reaction of pre-synthesized citrate stabilized AuNPs with PNVCL and CP1-CP5 by a direct 'grafting to' approach. The maximum absorbance wavelength (lambda(max)) of the surface plasmon resonance (SPR) band and size of all the thermoresponsive polymer coated AuNPs were found to be almost unchanged up to 65 degrees C (above the T-CP of PNVCL and CP5) in MilliQ water which is presumably due to electrostatic stabilization of the AuNPs by residual citrate groups on the surface. However, in 0.1 M NaCl aqueous solution the lambda(max) of the thermoresponsive AuNPs were red shifted when heated up to 65 degrees C which is attributed to the screening of the citrate negative charges on the surface of AuNPs that suppress electrostatic stabilization enabling T-induced aggregation leading to a shift in the SPR band. These thermoresponsive AuNPs may find applications as colorimetric temperature and/or salt sensors

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Surface-initiated controlled radical polymerization enhanced DNA biosensing

Cited by 28 publications

References 92 publications

Electrografting and Controlled Surface Functionalization of Carbon Based Surfaces for Electroanalysis

Electrografting and Controlled Surface Functionalization of Carbon Based Surfaces for Electroanalysis

The Bioanalytical and Biomedical Applications of Polymer Modified Substrates

Thermoresponsive polymer coated gold nanoparticles: from MADIX/RAFT copolymerization of N-vinylpyrrolidone and N-vinylcaprolactam to salt and temperature induced nanoparticle aggregation

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