Surface modification of a guided tissue regeneration membrane using tetracycline‐containing biodegradable polymers

Lee, Sang Bae; Lee, Doug Youn; Lee, Yong Keun; Kim, Kyoung Nam; Choi, Seong‐Ho; Kim, Kwang Mahn

doi:10.1002/sia.2761

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…Proper mechanical strength is also necessary to withstand the forces exerted by the overlying soft tissue flaps to prevent the collapse of the soft tissue, and to maintain wound space. To overcome poor mechanical strength of collagen membrane, Lee et al 218 combined synthetic biodegradable polymers with collagen membrane surface. Tetracycline-containing solutions of the biodegradable polymers PLA, poly(L-lactide-co-glycolide), and poly(glycolide-co-caprolactone) were used to coat collagen membrane by spray-coating.…”

Section: Biocompatible or Bioactive Membranesmentioning

confidence: 99%

Composites of functional polymeric hydrogels and porous membranes

et al. 2011

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Polymeric hydrogels are a most interesting class of ''soft matter'' with several established and many more possible applications as functional materials. In this review we will focus on the combination of polymeric hydrogels and porous membranes which leads to composites with promising functionality for, e.g., mass separations, sensing and analytics, (bio)catalysis, biomedical engineering and microsystem technologies. The combination of a rigid porous membrane with a soft functional hydrogel by a suited preparation technique enables that the functionality of the hydrogel can be applied in a unique way. The most important preparation strategies for hydrogel composite membranes, i.e., pore-filling, various surface-grafting methods and combinations thereof, will be discussed. The structural diversity of the hydrogels is based on the use of a wide range of synthetic monomers, but biopolymers or their derivatives can also be applied. The interplay of the membrane pore structure, the structure of the hydrogel and the distribution of the hydrogel in the pore space can lead to different types of composite membranes with completely different potential applications. The focus will be on promising examples for the various types of functional composite membranes, i.e., macroporous membrane adsorbers, antifouling filtration membranes, hydrogel-based ultrafiltration membranes, other separation membranes with pore-filling hydrogel as selective material, stimuli-responsive membranes and porous membrane valves and gates, as well as biocompatible or bioactive membranes.

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Section: Biocompatible or Bioactive Membranesmentioning

confidence: 99%

Composites of functional polymeric hydrogels and porous membranes

et al. 2011

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“…Recent studies that have examined modified resorbable GBR–GTR membranes with different antibacterial properties, suggested that membranes loaded with such materials might enhance GTR efficacy. These include among others mineralization with zinc phosphate shown to inhibit oral bacterial colonization (Chou et al 2007) and tetracycline impregnation which delayed collagen membrane degradation in vivo (Zohar et al 2004; Lee et al 2008).…”

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confidence: 99%

Degradation of collagen‐guided tissue regeneration membranes by proteolytic enzymes of Porphyromonas gingivalis and its inhibition by antibacterial agents

Sela

Babitski

Steinberg

et al. 2009

Clinical Oral Implants Res

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Previous studies have shown that whole cells of several periodontal pathogenic bacteria including Porphyromonas gingivalis may degrade the clinically used regeneration membranes Biomend Extend and Bio-Gide. Fractionation of P. gingivalis cells revealed that cell membrane-associated proteases are responsible for the in vitro degradation of the collagen membranes. In the present study, the specific role of extracellular vesicles and the purified Arg-gingipain enzyme of P. gingivalis in the degradation of three differently cross-linked collagen membranes (Ossix; Bio-Gide and Biomend Extend) was examined. In addition, the inhibitory effect of antibacterial agents and antibiotics used in local periodontal therapy on the enzymatic degradation was evaluated. The data presented show that while all tested collagen membranes, are prone to lysis by oral bacterial proteases, cross-linked membranes are more resistant to proteolysis. Furthermore, therapeutical concentrations of the antibacterial and antibiotic agents chlorhexidine, cetylpyridiniumchloride, minocycline and doxycycline were found to partially inhibit the enzymatic breakdown of the membranes, while metronidazole had no such effect. These results suggest that the presence of P. gingivalis cells, extracellular vesicles and enzymes in the vicinity of regeneration membranes in the periodontium, may change their physical structure and therefore alter their biological properties. Furthermore, the use of cross-linked collagen membranes and antibacterial agents may significantly inhibit this proteolytic process.

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“…The local application of minocycline ointment at regenerative sites was demonstrated to be benefical 29 . In addition, the impregnation of ePTFE or collagen membranes with tetracycline improved GTR efficacy 32,43 . In contrast, the addition of doxycycline to a polylactic acid membrane failed to enhance the treatment outcome of Class II furcation defects compared to a non–antibiotic‐loaded barrier or a bone graft 33 .…”

Section: Discussionmentioning

confidence: 99%