Surface Modification of Metallic Implants with Nanotubular Arrays via Electrochemical Anodization

Jin, Ming; Yao, Shenglian; Wang, Luning

doi:10.1002/9783527698646.ch9

Cited by 1 publication

(1 citation statement)

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“…In addition, surface coating of titanium nanostructure-based implants with optimum dimensions can significantly improve osseointegration by incrementing specific surface area, modification of surface topography, and establishing strong bonds with bone tissue. TiO 2 -NTs with the optimum length in cell adhesion were shown to drive migration of both osteoblast and mesenchymal stem cells, reinforcing the contacts between cells and implant surfaces [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties

et al. 2022

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Due to their high entrapment efficiency, anodized titanium nanotubes (TiO2-NTs) are considered effective reservoirs for loading/releasing strong antibiotics whose systemic administration is associated with diverse and severe side-effects. In this study, TiO2-NTs were synthesized by anodic oxidation of titanium foils, and the effects of electrolyte percentage and viscosity on their dimensions were evaluated. It was found that as the water content increased from 15 to 30%, the wall thickness, length, and inner diameter of the NTs increase from 5.9 to 15.8 nm, 1.56 to 3.21 µm, and 59 to 84 nm, respectively. Ciprofloxacin, a highly potent antibiotic, was loaded into TiO2-NTs with a high encapsulation efficiency of 93%, followed by coating with different chitosan layers to achieve a sustained release profile. The prepared formulations were characterized by various techniques, such as scanning electron microscopy, differential scanning calorimetry, and contact measurement. In vitro release studies showed that the higher the chitosan layer count, the more sustained the release. Evaluation of antimicrobial activity of the formulation against two endodontic species from Peptostreptococcus and Fusobacterium revealed minimum inhibitory concentrations (MICs) of 1 µg/mL for the former and the latter. To summarize, this study demonstrated that TiO2-NTs are promising reservoirs for drug loading, and that the chitosan coating provides not only a sustained release profile, but also a synergistic antibacterial effect.

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Section: Introductionmentioning

confidence: 99%