Surface modification of poly(hydroxybutyrate) films to control cell–matrix adhesion

Pompe, Tilo; Keller, Κ. A.; Mothes, Gisela; Nitschke, Mirko; Teese, Mark G.; Zimmermann, Ralf; Werner, Carsten

doi:10.1016/j.biomaterials.2006.08.028

Cited by 106 publications

(81 citation statements)

References 33 publications

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“…These results are in accordance with previously published findings on HUVECs-matrix adhesion on degradable polymer scaffolds [4]. Crosslinking of extracellular matrix protein right before their implementation as a coating on the polymer surface seemingly does not convey any beneficial effects on the adhesion of human endothelial cells in vitro.…”

Section: Discussionsupporting

confidence: 93%

Enhanced Endothelialization of PCL Through Chemical Activation, Protein Precoating and VEGF Stimulation

Storm

Teske

Wulf

et al. 2013

Biomedical Engineering / Biomedizinische Technik

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Section: Discussionsupporting

confidence: 93%

Enhanced Endothelialization of PCL Through Chemical Activation, Protein Precoating and VEGF Stimulation

Storm

Teske

Wulf

et al. 2013

Biomedical Engineering / Biomedizinische Technik

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“…11,[18][19][20]23,57,58,60 Surface chemical properties of implant materials have been shown to affect protein adsorption and acute cellular responses. 33,34,42,[61][62][63][64][65][66][67][68][69] In the present study, we examined the hypothesis that biomaterial-mediated fibrotic reactions could be substantially reduced by altering both the type and/ordensity of surface functionality…”

Section: Discussionmentioning

confidence: 99%

Species and Density of Implant Surface Chemistry Affect the Extent of Foreign Body Reactions

et al. 2008

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Implant-associated fibrotic capsule formation presents a major challenge for the development of long term drug release microspheres and implantable sensors. Since material properties have been shown to affect in vitro cellular responses and also to influence short term in vivo tissue responses, we have thus assumed that the type and density of surface chemical groups would affect the degree of tissue responses to microsphere implants. To test this hypothesis, polypropylene particles with different surface densities of -OH and -COOH groups, along with the polypropylene control (-CH 2 groups) were utilized. The influence of functional groups and their surface densities on tissue reactions were analyzed using a mice subcutaneous implantation model. Our comparative studies included determination and correlation of the extents of fibrotic capsule formation, cell infiltration into the particles and recruitment of CD11b+ inflammatory cells for all of the substrates employed. We have observed major differences among microspheres coated with different surface functionalities. Surfaces with -OH surface groups trigger the strongest responses while -COOH rich surfaces prompt the least tissue reactions. However, variation of the surface density of either functional group has a relatively minor influence on the extent of fibrotic tissue reactions. The present results show that surface functionality can be used as a powerful tool to alter implant-associated fibrotic reactions and, potentially, to improve the efficacy and function of drug delivery microspheres, implantable sensors and tissue engineering scaffolds.

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“…Characteristic amino-related bonds, such as C-N stretching at 1190-1130 cm−1 or N-H (1400-1000 cm−1), were not identified. However, the amino (C-N) and amide (N-C_O) groups on the polymer surface after the ammonia-plasma treatment were identified using X-ray photoelectron spectroscopy [15,17]. Therefore, the FT-IR ATR technique did not provide a clear understanding of the formation of amino, C_O, C-O-C or other groups because only the surface layers of the polymers were modified by the plasma and the information depth of the analysis was in the range of 1-2 μm.…”

Section: Chemical Analysismentioning

confidence: 99%

“…However, the wettability of the P3HB may vary with the structure and composition of the surface, e.g., the surface topography, content of the crystalline and amorphous phases, and the presence of polar functional groups with a specific charge [10]. Radio-frequency (RF) plasma is usually used to treat the surface of different polymers [14,15]. Reactive gases allowus to obtain the necessary functional groups on the P3HB surface and also impart other properties, such as bioactivity [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Surface wettability and energy effects on the biological performance of poly-3-hydroxybutyrate films treated with RF plasma

Syromotina

Surmenev

Boyandin

et al. 2016

Materials Science and Engineering: C

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АbstractThe surface properties of poly-3-hydroxybutyrate (P3HB) membranes were modified using oxygen and an ammonia radio-frequency (RF, 13.56 MHz) plasma. The plasma treatment procedures used in the study only affected the surface properties, including surface topography, without inducing any significant changes in the crystalline structure of the polymer,with the exception being a power level of 250W. Thewettability of themodified P3HB surfaces was significantly increased after the plasma treatment, irrespective of the treatment procedure used. Itwas revealed that both surface chemistry and surface roughness changes caused by the plasma treatment affected surface wettability. A treatment-induced surface aging effect was observed and resulted in an increase in the water contact angle and a decrease in the surface free energy. However, the difference in the water contact angle between the polymers that had been treated for 4 weeks and the untreated polymer surfaces was still significant. A dependence between cell adhesion and proliferation and the polar component of the surface energy was revealed. The increase in the polar component after the ammonia plasma modification significantly increased cell adhesion and proliferation on biodegradable polymer surfaces compared to the untreated P3HB and the P3HB modified using an oxygen plasma.

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Surface modification of poly(hydroxybutyrate) films to control cell–matrix adhesion

Cited by 106 publications

References 33 publications

Enhanced Endothelialization of PCL Through Chemical Activation, Protein Precoating and VEGF Stimulation

Enhanced Endothelialization of PCL Through Chemical Activation, Protein Precoating and VEGF Stimulation

Species and Density of Implant Surface Chemistry Affect the Extent of Foreign Body Reactions

Surface wettability and energy effects on the biological performance of poly-3-hydroxybutyrate films treated with RF plasma

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