Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts

Kang, Inn‐Kyu; Choi, Soo-Kyung; Shin, Dong‐Sik; Yoon, Sung Chul

doi:10.1016/s0141-8130(00)00165-3

Cited by 87 publications

(37 citation statements)

References 24 publications

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“…The values for binding energies of these carbon species are well known and can be found in the literature. 16,17 The chemical species in the molecular structure (Scheme 1) can be identified by association to the electro-negativity differences. The known electro-negativity differences (∆x) in Pauling scale C-H are: ∆x = 0.23, C-C: ∆x = 0.18 C-O: ∆x = 1.20; C=O: ∆x = 1.28 , 18 which justify qualitatively the chemical shift.…”

Section: Surface Propertiesmentioning

confidence: 99%

Structural impact of hydroxyvalerate in polyhydroxyalkanoates (PHAscl) dense film monitored by XPS and photothermal methods

Silva¹,

Vargas²,

Poley³

et al. 2005

J. Braz. Chem. Soc.

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Filmes densos de poli(3-hidrobutirato) e poli(3-hidroxibutirato-co-3-hidroxivalerato) com espessuras de 90 µm foram obtidos utilizando o método "casting" de deposição e caracterizados por espectroscopia de fotoelétrons, calorimetria diferencial e métodos fotoacústicos. As frações molares de hidroxivalerato utilizadas foram de 8, 14 e 22 % molar. Seguindo uma mesma tendência, a capacidade térmica específica e a temperatura de transição vítrea diminuem com o aumento da concentração de hidroxivalerato.Poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) polymer dense films with thickness of 90 µm were obtained by the casting method and characterized using X-ray photoelectron spectroscopy, differential scanning calorimetric and photo-thermal methods. The HV molar fractions in the copolymer structure were 8, 14 and 22 mol %. The measured specific thermal capacity and the glass transition temperature of the P3(HB-co-x%HV) decrease for increasing hydroxyvalerate content following a similar trend. Keywords: polymers, photoacoustics, XPS, thermal properties IntroductionIn the last years, science and industry have given special attention to the development of biodegradable polymer materials as consequence of today ecological problems caused by most of the chemical and petrochemical synthesized polymers disposed in the environment. 1 Chemically and petrochemically synthesized polymers are generally resistant to enzymatic attack. Although some of these synthetic polymers can be microbiologically degraded, the process of degradation is slow in contrast to the biodegradability of the polymers of biological origin. 2 The biodegradability is not the only characteristic that makes the polymers of biological origin attractive, also their biosynthesis from renewable carbon sources, based on agricultural products, allows a sustainable closed process for the production and use of such polymers.One important family of the biologically produced thermoplastic polyesters is formed by the polyhydroxyalkanoaes (PHAs). Important members of this family are the P3HB and P(3HB-co-3HV)copolymers synthesized and intracellularly stored by numerous prokaryotes by well know fermentation process. The stereoregularity of P3HB makes it a highly crystalline material having melting point of 177 o C, close to that of polypropylene among others similarities, although the biopolymer is stiffer and more brittle. 3,4 The P(3HB-co-3HV) chains also show crystalline conformations and the co-monomer distribution is statistically random. The properties of the copolymers of 3HB and 3 HV changes depending on their HV contents. The minimum of the melting point (≅80 o C, pseudoeutectic point) of the copolymers is observed for a 30% mole fraction of HV. 5,6 The accurate determination of the thermal properties of polymers and particularly of PHAs is of fundamental importance in many processes and engineering projects aiming at the expansion of the uses of these biodegradable materials. In the present work, the effect of HV contents in the P(3HB-co-...

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Section: Surface Propertiesmentioning

confidence: 99%

Structural impact of hydroxyvalerate in polyhydroxyalkanoates (PHAscl) dense film monitored by XPS and photothermal methods

Silva¹,

Vargas²,

Poley³

et al. 2005

J. Braz. Chem. Soc.

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“…Nonpolymerizing gas plasma can create reactive sites such as peroxide 4 and sulfonic acid groups 5 on the surface of polymers. Plasma processes have been used to increase the hydrophilicity of PLLA and to improve its cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration

Huang

et al. 2007

J Biomedical Materials Res

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Attachment to and proliferation on the substrate are deemed important considerations when Schwann cells (SCs) are to be seeded in synthetic nerve grafts. Good attachment is a prerequisite for the SCs to survive. Fast proliferation will yield large numbers of SCs in a short time, which appears to be promising for stimulating peripheral nerve regeneration. However, surface properties are the dominating factor in influencing the interactions between cells and synthetic nerve grafts. The aim of this study was to investigate the surface effects of laminin modified PLGA and chitosan membranes after chemical method and plasma treatment. Laminin, the extracellular matrix protein, is a permissive protein for SCs adhesion used in neural regeneration. The surface properties of laminin modified membranes were assayed by BCA, FTIR and XPS analysis. Results showed that laminin was covalently bonded onto the surface of both PLGA and chitosan membranes either by chemical method or by oxygen plasma treatment. The cell affinity of the laminin modified membranes was verified by Schwann cells culturing. Our results also indicate that oxygen plasma is indeed a better method to incorporate laminin onto the surface of membrane. Laminin-modified chitosan membrane significantly increases SCs attachment and affinity for directing peripheral nerve regeneration.

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“…PHAs families are classified into two types: (a) short chain length PHAs (PHAscl) which contain 3−5 carbon atoms (poly-3-hydroxybutyrate (P3HB) and poly-4 hydroxybutyrate (P4HB)) and medium chain length PHAs (PHAmcl) contain 6−14 and more than carbon atoms (poly(3-hydroxyhexanoate) P(3HHx) and poly(3-hydroxyoctanoate) P(3HO) [156]. Long chain length (PHAlcl) contain above 14 carbon atoms.…”

Section: Properties Of Phasmentioning

confidence: 99%

“…The presence of 3-hydroxyl group and the carboxylic groups allows the further modification, for example, phenoxy, cyanophenoxy, halogens, carboxyl, hydroxyl, epoxy, methyl ester, and thiophenoxy groups [156]. Among the PHAs, poly(β-hydroxybutyrates) (3-hydroxybutyric acid) is the first discovered homopolymer, with wide varieties of microbes accumulated and has most similar properties to that of polypropylene.…”

Section: Properties Of Phasmentioning

confidence: 99%

Exploring biodegradable polymer production from marine microbes

Rasu¹,

Arun²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts

Cited by 87 publications

References 24 publications

Structural impact of hydroxyvalerate in polyhydroxyalkanoates (PHAscl) dense film monitored by XPS and photothermal methods

Structural impact of hydroxyvalerate in polyhydroxyalkanoates (PHAscl) dense film monitored by XPS and photothermal methods

Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration

Exploring biodegradable polymer production from marine microbes

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