Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Alavi, Mehran; Hamblin, Michael R.; Mozafari, M. R.; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo

doi:10.55705/cmbr.2022.338888.1039

Cited by 34 publications

(23 citation statements)

References 67 publications

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“…They can also do this by binding directly to biological macromolecules or indirectly producing reactive oxygen species (ROS). However, under physiological circumstances, using the higher amounts of MNPs required for antibacterial activity can result in poor biocompatibility and cytotoxicity, modification of the MNP surface with additional biocompatible antibacterial compounds is a promising strategy [ 54 ]. In order to understand the wound healing process, it is necessary to understand the antibacterial mechanism.…”

Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

“…The mechanism underlying the antibacterial activity of HA nanocomposites is shown in Figure 2 . The main steps are as follows: (a) Gram-positive bacteria and Gram-negative bacteria released hyaluronidase (HAase), which causes specific cleaved of the HA-Ag-drug nanocarrier [ 53 , 54 ]. Furthermore, metabolic activities of the antibacterial agent cause an acidic environment (H + ) in the vicinity of bacteria [ 55 ].…”

Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

“…(f) MNPs can easily enter bacterial cells by enhancing cell membrane permeability and then biochemically attach to ribosome at h44 in the 30S and H69 in the 50S subunit and prevent protein formation [ 60 ]. (g) Damaged DNA caused by MNPs can interact with intracellular enzymes and disrupt cellular metabolism-induced intracellular ROS production [ 54 , 61 , 62 ]. (h) Furthermore, interactions between MNPs and antibiotics produce MNPs-antibiotic complexes, which stimulate M + ion release at cell walls and inhibit bacterial growth [ 63 ].…”

Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

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Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Sudhakar

Rao

et al. 2022

Pharmaceutics

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Hyaluronic acid (HA) based nanocomposites are considered excellent for improving wound healing. HA is biocompatible, biodegradable, non-toxic, biologically active, has hemostatic ability, and resists bacterial adhesion. HA-based nanocomposites promote wound healing in four different sequential phases hemostasis, inflammation, proliferation, and maturation. The unique biological characteristics of HA enable it to serve as a drug, an antibacterial agent, and a growth factor, which combine to accelerate the healing process. In this review, we focus on the use of HA-based nanocomposites for wound healing applications and we describe the importance of HA for the wound healing process in each sequential phase, such as hemostasis, inflammation, proliferation, and maturation. Metal nanoparticles (MNPs) or metal oxide nanoparticles (MO-NPs) loaded with HA nanocomposite are used for wound healing applications. Insights into important antibacterial mechanisms are described in HA nanocomposites. Furthermore, we explain antibiotics loaded with HA nanocomposite and its combination with the MNPs/MO-NPs used for wound healing applications. In addition, HA derivatives are discussed and used in combination with the other polymers of the composite for the wound healing process, as is the role of the polymer in wound healing applications. Finally, HA-based nanocomposites used for clinical trials in animal models are presented for wound healing applications.

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Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

Section: Wound Healing Applications Of Metal Nanoparticles (Mnps)mentioning

confidence: 99%

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Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Sudhakar

Rao

et al. 2022

Pharmaceutics

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“…Long-term oral administration of diclofenac sodium is easy to destroys the gastric mucosal barrier and cause gastric ulcer, which often leads to digestive tract reactions such as nausea, vomiting, and upper abdominal fullness. When this drug is made into external preparations, such as flexible nanoliposomes, as a new type of transdermal drug delivery carrier, with high self-deformation, it can efficiently pass through skin pores several times smaller than itself and enable some macromolecular drugs that are difficult to penetrate skin successfully penetrate or even enter systemic circulation, eliminating the firstpass effect and exerting greater effects (22)(23)(24)(25)(26)(27).…”

Section: Comparison Of Treatment Effects Between the Two Groupsmentioning

confidence: 99%

Comparison of Therapeutic Effects of Topical Application of Diclofenac Sodium Nanoparticles and Conventional Placebo on Knee Osteoarthritis

Li¹,

Guo²,

Zhang³

2022

Cell Mol Biol (Noisy-le-grand)

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The objective of this study was to investigate the therapeutic effects of diclofenac sodium nanoparticles and traditional placebo on Knee Osteoarthritis (KOA). 80 KOA patients admitted to the Inpatient Department of Orthopedics of Sunshine Union Hospital from June 2020 to July 2021 were selected, and divided into 40 cases using diclofenac sodium nano flexible liposomes topically (study group) and 40 cases using conventional placebo topically (control group). The two groups were compared for knee swelling, knee pain, and knee function scores before treatment, on the 3rd, 7 th , and 14 th days after treatment, and the incidence of adverse events during treatment was recorded. It was found that the knee swelling scores of the study group were significantly lower than those of the control group on the 7th and 14th days after treatment, and that the knee pain score of the study group was significantly lower than that of the control group at the 7th day after treatment, and that the knee joint mobility disorder scores of the study group were significantly lower than those of the control group at the 7th and 14 th days after treatment. The total effective rate of the study group was 85.0% (34/30), which was higher than that of the control group (12.5% (5/30)) (P<0.05). In conclusion, local application of diclofenac sodium nano flexible liposomes showed a stronger effect on KOA than traditional placebo, and no significant adverse reactions occurred.

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“…However, the over-use of herbicides has led to serious human health and environmental concerns (1). Nano-encapsulation of herbicides by increasing the effectiveness of herbicides can reduce their usage amount (2).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of chloridazon-loaded alginate/chitosan nanocapsules

Babaei¹,

Kahrizi²,

Nosratti³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Herbicides contaminate soil, atmosphere, groundwater aquifers and runoff water while threatening human health. Nano-encapsulation of herbicides used in agriculture is one of the strategies to reduce the impact of such widely used agrochemicals. Nano-encapsulated herbicides are controlled membrane systems in which the active ingredient is coated with semi-permeable membranes, which may be organic or inorganic polymers. In our study, chloridazon herbicide was selected as the active ingredient to be nano-encapsulated. The ionic gelation method was used to synthesize nanocapsules consisting of alginate and chitosan for chloridazon encapsulation. Alginate-chitosan nanoparticles were prepared in a two-step process involving the ionotropic pre-gelation of an alginate core and then the formation of a chitosan polyelectrolyte complex. The alginate-chitosan nanocapsules containing chloridazon were synthesized at a size of 253 nm with a polydispersity index (PDI) of 0.266 and a zeta potential of -1.43 mV. The loading capacity and entrapment efficiency of these nanocapsules were 14% and 57%, respectively. The monitoring of chloridazon release from formulated alginate-chitosan nanocapsules was performed using dialysis tube testing and UV spectroscopy. The results indicated the slow release of chloridazon from loaded alginate-chitosan nanocapsules. controlled release and increasing the duration of action of chloridazon, along with reducing the required dose, is promising in reducing the adverse effects of chloridazon. Overall, the synthesized alginate-chitosan nanocapsules, as nanocarriers, have effective properties such as controlled release, prolonged action time, and reduced dose, which are expected to reduce the adverse effects of chloridazon on health and the environment, and improve precision agriculture.

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Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Cited by 34 publications

References 67 publications

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Recent Progress on Hyaluronan-Based Products for Wound Healing Applications

Comparison of Therapeutic Effects of Topical Application of Diclofenac Sodium Nanoparticles and Conventional Placebo on Knee Osteoarthritis

Preparation and characterization of chloridazon-loaded alginate/chitosan nanocapsules

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