Surface modification of titanium by etching in concentrated sulfuric acid

Ban, Seiji; Iwaya, Yukari; Kōno, Hiroshi; Sato, Hideo

doi:10.1016/j.dental.2005.09.007

Cited by 184 publications

(143 citation statements)

References 22 publications

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“…Moreover, this activation method does not modify the topography (i.e. roughness) of the surfaces, as observed with other methods such as acidic 51 or alkaline 52,53 etchings.…”

Section: Discussionmentioning

confidence: 55%

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Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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Dental implant failure can be associated to infections which develop into periimplantitis. In order to reduce biofilm formation, several strategies focusing on the use of antimicrobial peptides (AMP) have been studied. To covalently immobilize these molecules onto metallic substrates several techniques have been developed, including silanization and polymer brush prepared by surface-initiated atom transfer radical polymerization (ATRP), with varied peptide binding yield and antibacterial performance. The aim of the present study was to compare the efficiency of these methods to immobilize the lactoferrin-derived hLf1-11 antibacterial peptide onto titanium, and evaluate their antibacterial activity in vitro.Smooth titanium samples were coated with hLf1-11 peptide under three different conditions: silanization with APTES, and polymer brush based coatings with two different silanes. Peptide presence was determined by X-ray photoelectron spectroscopy and the mechanical stability of the coatings was studied under ultrasonication. The LDH assays confirmed that HFFs viability and proliferation were no affected by the treatments. The in vitro antibacterial properties of the modified surfaces were tested with two oral strains (Streptococcus sanguinis and Lactobacillus salivarius) showing an outstanding reduction. A higher decrease in bacterial attachment was noticed when samples were modified by ATRP methods compared to silanization. This effect is likely due to the capacity to immobilize more peptide on the surfaces using polymer brushes and the non-fouling nature of polymer PDMA segment.3

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“…Moreover, this activation method does not modify the topography (i.e. roughness) of the surfaces, as observed with other methods such as acidic 51 or alkaline 52,53 etchings.…”

Section: Discussionmentioning

confidence: 55%

“…However, due to the relatively chemical inertness of titanium oxide layers, its surface modification often requires the use of activation methods 49,50,51 . In this work, oxygen plasma was selected to clean and activate the surfaces prior to their functionalization.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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“…However, studies in this area are rarely reported in biomaterials science. Our previous study revealed that etching in concentrated sulfuric acid produced a rougher titanium surface than in HCl, H3PO4, HF, or HNO3 20) . It was also demonstrated that the surface roughness and weight loss of commercially pure titanium (cpTi) plates increased with acid temperature and etching time in concentrated sulfuric acid 21) .…”

Section: Introductionmentioning

confidence: 99%

“…Our previous study revealed that etching in concentrated sulfuric acid produced a rougher titanium surface than in HCl, H3PO4, HF, or HNO3 20) . It was also demonstrated that the surface roughness and weight loss of commercially pure titanium (cpTi) plates increased with acid temperature and etching time in concentrated sulfuric acid 21) . Moreover, etching in concentrated sulfuric acid was found to be a simple and effective surface modification method of cpTi for bonding to veneering composite resins 22) as well as an effective surface pretreatment for apatite coating on titanium using an alternate soaking method 23) .…”

Section: Introductionmentioning

confidence: 99%

Surface Properties and Biocompatibility of Acid-etched Titanium

et al. 2008

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The purpose of this study was to evaluate the effects of acid-etched titanium on the biological responses of osteoblast-like MC3T3-E1 cells. Four types of treatments (polishing, sandblasting, concentrated H2SO4 etching, and concentrated H2SO4 etching with vacuum firing) were carried out on the surfaces of commercially pure titanium (cpTi) disks. MC3T3-E1 cells were then cultured on the treated cpTi surfaces. Through surface roughness measurement and SEM analysis, it was found that the acid-etched surfaces showed higher roughness values than the sandblasted ones. Scanning electron microscope analysis showed that the cells on the disks treated with acid-etching and acid-etching with vacuum firing spread as well as the sandblasted ones. There were no significant differences in cell proliferation and collagen production on cpTi among the four different surface treatments. Based on the results of this study, it was concluded that etching with concentrated sulfuric acid was a simple and effective way to roughen the surface of titanium without compromising its biocompatibility.

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“…Therefore, controlling the respective populations of epithelial and mesenchymal stem cells to shift the balance in favor of mesenchymal stem cells could help to ensure osseointegration. To date, various surface modifications have been developed, such as sandblasting and acid etching (SLA), hydrothermal hot pressing, laser pulse, dip coating, and spray plasma coating [16,17,18,19,20,21,22,23,24,25,26]. However, as yet, no method has been devised to regulate cell populations in functional dental implants.…”

Section: Discussionmentioning

confidence: 99%