Surface modification on rare-earth doped ceramic nanophosphors via ligand exchange method for near-infrared biophotonics

Kamimura, Masao; Suyari, Satoru; Matsumoto, Taiki; Soga, Kohei

doi:10.2494/photopolymer.28.711

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…NaYF 4 NPs doped with Yb 3+ , Ho 3+ , and Er 3+ ions were prepared by a thermal decomposition method reported elsewhere 45 , 46 with minor modifications. Yttrium chloride hexahydrate (Sigma-Aldrich, St Louis, MO, USA) (0.78 mmol), ytterbium(III) chloride hexahydrate (Wako Pure Chemical Industries, Osaka, Japan) (0.20 mmol), holmium(III) chloride hexahydrate (Wako Pure Chemical Industries) (0.03 mmol), and erbium(III) chloride hexahydrate (Wako Pure Chemical Industries) (0.005 mmol) were mixed in a solvent composed of distilled water (0.67 mL), OA (14 mL; Sigma-Aldrich), and 1-octadecene (30 mL; Wako Pure Chemical Industries).…”

Section: Methodsmentioning

confidence: 99%

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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Luminescence nanothermometry has attracted much attention as a non-contact thermal sensing technique. However, it is not widely explored for in vivo applications owing to the low transparency of tissues for the light to be used. In this study, we performed biological temperature sensing in deep tissues using β-NaYF4 nanoparticles co-doped with Yb3+, Ho3+, and Er3+ (NaYF4: Yb3+, Ho3+, Er3+ NPs), which displayed two emission peaks at 1150 nm (Ho3+) and 1550 nm (Er3+) in the >1000 nm near-infrared wavelength region, where the scattering and absorption of light by biological tissues are at the minimum. The change in the luminescence intensity ratio of the emission peaks of Ho3+ and Er3+ (IHo/IEr) in the NaYF4: Yb3+, Ho3+, Er3+ nanothermometer differs corresponding to the thickness of the tissue. Therefore, the relationship between IHo/IEr ratio and temperature needs to be calibrated by the depth of the nanothermometer. The temperature-dependent change in the IHo/IEr was evident at the peritoneal cavity level, which is deeper than the subcutaneous tissue level. The designed experimental system for temperature imaging will open the window to novel luminescent nanothermometers for in vivo deep tissue temperature sensing.

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Section: Methodsmentioning

confidence: 99%

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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“…The OA ligands on the surfaces of the NaGdF 4 :Yb 3+ , Er 3+ NPs were replaced with PEG-b-PAAc by a stepwise ligand-exchange process, according to previously reported methods [17,56,57], with slight modifications. The OA-capped NaGdF 4 :Yb 3+ ,Er 3+ NPs were dispersed in cyclohexane (1 mg/mL) and 50 mg of NOBF 4 was dissolved in 10 mL of DMF.…”

Section: Preparation Of Peg-nagdf 4 :Yb 3+ Er 3+ Npsmentioning

confidence: 99%

Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging

Okubo

Takeda

Murayama

et al. 2021

Science and Technology of Advanced Materials

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“…For fulfilling this criterion, a relatively simple and quick method was developed for building up the surface structure in Fig. 1 [17][18][19][20]. Moreover, the polyvalent effect of the cationic PAMA segment in PEG-b-PAMA on the negative charged YPO 4 NPs surface was anticipated.…”

Section: Introductionmentioning

confidence: 99%

Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal <i>in vivo</i> Imaging Based on Rare-earth Doped Ceramic Nanophosphors

Kamimura

Saito

Hyodo

et al. 2016

J. Photopol. Sci. Technol.

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In this study, we aimed to develop a dual-modal in vivo imaging based on over-1000 nm near-infrared (OTN-NIR) fluorescence and single photon emission computed tomography (SPECT)/computed tomography (CT). As an OTN-NIR nanophosphor material, Ytterbium and erbium ion co-doped yttrium phosphate nanoparticles (YPO 4 NPs) was synthesized by a hydrothermal synthesis method. Biocompatible poly(ethylene glycol) (PEG)/polycation block copolymer and radioactive 111 In were introduced on the YPO 4 NPs surface In-YPO 4 NPs). The PEG- 111In-YPO 4 NPs showed high dispersion stability in physiological saline and excellent radioactivity in any of PBS and FBS solutions. Furthermore, in vivo OTN-NIR fluorescence and SPECT /CT imaging of live mice was performed. Strong OTN-NIR emission from the blood vessel and organs of live mice were observed. Moreover, SPECT/CT images clearly showed the three dimensional images of the live mice. Therefore, In-YPO 4 NPs is an attractive candidate for the OTN-NIR fluorescence and SPECT/CT dual-modal imaging probe, and the concept can be served as a novel platform for real-time imaging and three dimensional quantitative determinations.

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Surface modification on rare-earth doped ceramic nanophosphors via ligand exchange method for near-infrared biophotonics

Cited by 6 publications

References 10 publications

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging

Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal <i>in vivo</i> Imaging Based on Rare-earth Doped Ceramic Nanophosphors

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