Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide

Shi, Yongli; Xue, Jianming; Liu, Jia; Du, Qian; Niu, Jie; Zhang, Dongyang

doi:10.1016/j.colsurfb.2017.10.037

Cited by 61 publications

(13 citation statements)

References 24 publications

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“…On the other hand, large surface area‐to‐volume ratio and the inherent hydrophobicity of electrospun synthetic polymeric scaffolds are major disadvantages of these biomaterials that can trigger a sequential chain of pathophysiological cascades, including adsorption of nonspecific proteins, recruitment of macrophage, and finally fibrosis at the tissue–scaffold interface . An ideal technique for surface decoration is expected to eliminate nonspecific protein adsorption and permit host macrophage phenotype modulation . To this end, Qian et al prepared heparin disaccharide (HD)‐modified nanofibrous scaffolds with combined surface treatment by the LBL assembly approach and click chemistry technique to regulate the foreign body reactions to nanofibrous substrates for tissue engineering purposes.…”

Section: Surface Modification Methodsmentioning

confidence: 99%

“…The results indicated that the coating of TOL‐PLGA‐NPs with chitosan improved the thermostability and therefore NPs could release TOL in a sustained manner at pH 7.4 compared with TOL‐PLGA‐NPs. In addition, in vivo treatment of the diabetic rat by oral administration of chitosan‐coated TOL‐PLGA‐NPs presented great hypoglycemic effects …”

Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

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Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

322

200

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Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed.

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Section: Surface Modification Methodsmentioning

confidence: 99%

Section: Effects Of Bulk Properties On Cellular Behaviormentioning

confidence: 99%

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Amani

Arzaghi

Bayandori

et al. 2019

Adv Materials Inter

322

200

View full text Add to dashboard Cite

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“…The surface crosslinked CS membrane has also been applied for function modication of silver nanoparticles, 41,42 catalase 43 and PLGA nanoparticles. 44 Fig. 4c displays the morphology of reconstituted spray-dried chito-cubosomes.…”

Section: Physicochemical Characterizationsmentioning

confidence: 99%

Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

et al. 2019

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“…Further, when a following thermal event overlaps any stages of a preceding thermal event, it is not easy to assess each event qualitatively or quantitatively. Therefore, in many studies of characterizing PLGA-based micro-/nano-particles through TG experiments, information on residual solvents was not thoroughly discussed [8][9][10][11]. To identify and quantify gas byproducts, TG should be combined with the so-called evolved gas analysis (EGA).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry

Shim

Sah

2020

Pharmaceutics

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Thermogravimetry does not give specific information on residual organic solvents in polymeric matrices unless it is hyphenated with the so-called evolved gas analysis. The purpose of this study was to apply, for the first time, derivative thermogravimetry (DTG) to characterize a residual solvent and a drug in poly-d,l-lactide-co-glycolide (PLGA) microspheres. Ethyl formate, an ICH class 3 solvent, was used to encapsulate progesterone into microspheres. DTG provided a distinct peak, displaying the onset and end temperatures at which ethyl formate started to evolve from to where it completely escaped out of the microspheres. DTG also gave the area and height of the solvent peak, as well as the temperature of the highest mass change rate of the microspheres. These derivative parameters allowed for the measurement of the amount of residual ethyl formate in the microspheres. Interestingly, progesterone affected not only the residual solvent amount but also these derivative parameters. Another intriguing finding was that there was a linear relationship between progesterone content and the peak height of ethyl formate. The residual solvent data calculated by DTG were quite comparable to those measured by gas chromatography. In summary, DTG could be an efficient and practical quality control tool to evaluate residual solvents and drugs in various polymeric matrices.

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Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide

Cited by 61 publications

References 24 publications

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques

Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry

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