Surface plasmon resonance (SPR) sensing for small molecules in biofluids

Masson, Jean-François; Zhao, Sandy Shuo; Bukar, N. V.; Pelletier, Joelle N.; Labrecque-Carbonneau, Jérémie; McKeating, Kristy S.; Yockell-Lelièvre, Hélène

doi:10.1364/sensors.2015.sew1b.2

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…This detection system allowed us to evaluate vancomycin with a high sensitivity (0.41 AU/decade) and a low LoD (84 nM) in clinically relevant ranges (from 0.3 to 40 µM) for an extremely low volume (0.6 nL), as well as to perform rapid measurements (<5 min in total) [187]. Other studies to measure methotrexate, testosterone, and antibiotics using SPR used functionalized chip surfaces to evaluate these drugs in biofluids [188].…”

Section: Surface Functionalization In Tdmmentioning

confidence: 99%

Optical Biosensors for Therapeutic Drug Monitoring

et al. 2019

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Therapeutic drug monitoring (TDM) is a fundamental tool when administering drugs that have a limited dosage or high toxicity, which could endanger the lives of patients. To carry out this monitoring, one can use different biological fluids, including blood, plasma, serum, and urine, among others. The help of specialized methodologies for TDM will allow for the pharmacodynamic and pharmacokinetic analysis of drugs and help adjust the dose before or during their administration. Techniques that are more versatile and label free for the rapid quantification of drugs employ biosensors, devices that consist of one element for biological recognition coupled to a signal transducer. Among biosensors are those of the optical biosensor type, which have been used for the quantification of different molecules of clinical interest, such as antibiotics, anticonvulsants, anti-cancer drugs, and heart failure. This review presents an overview of TDM at the global level considering various aspects and clinical applications. In addition, we review the contributions of optical biosensors to TDM.

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Section: Surface Functionalization In Tdmmentioning

confidence: 99%