Surface Texturing Design to Enhance Echogenicity of Biopsy Needles During Endoscopic Ultrasound Imaging

Markham, Sarah; Mani, A. A.; Bauer, Joanna; Silien, Christophe; Tofail, Syed A. M.

doi:10.1016/j.ultrasmedbio.2020.04.034

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…The echogenicity of Si allows the simulator to be identified in US images due to the presence of an additive material (graphite), serving as a scatterer agent in Si ( 21 ) . Additionally, the higher echogenicity expected for a soft-tissue which has a rougher or varied dimple surface rather than a flat surface ( 22 ) .…”

Section: Discussionmentioning

confidence: 99%

Anatomically realistic aortic dissection simulator as a potential training tool for point-of-care ultrasound

Rahmah,

Al-Ashwal,

Salim

et al. 2024

JUltrason

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Aim: Simulators for aortic dissection diagnosis are limited by complex anatomy influencing the accuracy of point-of-care ultrasound for diagnosing aortic dissection. Therefore, this study aimed to create a healthy ascending aorta and class DeBakey, type II aortic dissection simulator as a potential point-of-care ultrasound training model. Material and methods: 3D mould simulators were created based on computed tomography images of one healthy and one DeBakey type II aortic dissection patient. In the next step, two polyvinyl alcohol-based and two silicone-based simulators were synthesised. Results: The results of the scanning electron microscope assessment showed an aortic dissection simulator’s surface with disorganised surface texture and higher root mean square (RMS or Rq) value than the healthy model of polyvinyl alcohol (RqAD = 20.28 > RqAAo = 10.26) and silicone (RqAD = 33.8 > RqAAo = 23.07). The ultrasound assessment of diameter aortic dissection showed higher than the healthy ascending aorta in polyvinyl alcohol (dAD = 28.2 mm > dAAo = 20.2 mm) and Si (dAD = 31.0 mm > dAAo = 22.4 mm), while the wall thickness of aortic dissection showed thinner than the healthy aorta in polyvinyl alcohol, which is comparable with the actual aorta measurement. The intimal flap of aortic dissection was able to replicate and showed a false lumen in the ultrasound images. The flap was measured quantitatively, indicating that the intimal flap was hyperechoic. Conclusions: The simulators were able to replicate the surface morphology and echogenicity of the intimal flap, which is a linear hyperechoic area representing the separation of the aorta wall.

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Section: Discussionmentioning

confidence: 99%

Anatomically realistic aortic dissection simulator as a potential training tool for point-of-care ultrasound

Rahmah,

Al-Ashwal,

Salim

et al. 2024

JUltrason

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“…24 The CRS symptoms seen in this patient appeared to be related to tumor recurrence/metastasis rather than treatment, which, if anything, in controlling the tumor also controlled the inflammatory syndrome. [25][26][27] Although CREB1 and ATF1 members of the CREB family of transcription factors may participate interchangeably in gene fusions within the same tumor type, there is a striking propensity for the EWSR1:: CREB1 fusion to occur in AFH and EWSR1::ATF1 in soft tissue clear cell sarcoma (CCS), whereas in GI-CCS the two fusion events occur with similar prevalence. 1 AFH is a mesenchymal neoplasm of borderline malignant potential, typically occurring in the superficial soft tissues of children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Modeling Extraordinary Response Through Targeting Secondary Alterations in Fusion-Associated Sarcoma

Vanoli,

Song,

Dermawan

et al. 2024

JCO Precis Oncol

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PURPOSE Targeted therapy in translocation-associated sarcomas has been limited to oncogenic activation of tyrosine kinases or ligands while gene fusions resulting in aberrant expression of transcription factors have been notoriously difficult to target. Moreover, secondary genetic alterations in sarcomas driven by translocations are uncommon, comprising mostly alterations in tumor suppressor genes ( TP53, CDKN2A/ B). Our study was triggered by an index patient showing a dramatic clinical response by targeting the secondary BRAF V600E mutation in a metastatic angiomatoid fibrous histiocytoma (AFH) harboring the typical EWSR1::CREB1 fusion. MATERIALS AND METHODS The patient, a 28-year-old female, was diagnosed with an AFH of the thigh and followed a highly aggressive clinical course, with rapid multifocal local recurrence within a year and widespread distant metastases (adrenal, bone, liver, lung). The tumor showed characteristic morphologic features, with histiocytoid cells intermixed with hemorrhagic cystic spaces and lymphoid aggregates. In addition to the pathognomonic EWSR1::CREB1 fusion, targeted DNA sequencing revealed in both primary and adrenal metastatic sites a hot spot BRAF V600E mutation and a CDKN2A/ B deletion. Accordingly, the patient was treated with a BRAF-MEK inhibitor combination (encorafenib/binimetinib) showing an excellent but short-lived response. RESULTS Using a CRISPR-Cas9 approach, we introduced the BRAF c.1799 T>A point mutation in human embryonic stem (hES) cells harboring a conditional EWSR1 (exon7):: CREB1 (exon7) translocation and further differentiated to mesenchymal progenitors (hES-MP) before fusion expression. The cells maintained the fusion transcript expression and the AFH core gene signature while responding to treatment with encorafenib and binimetinib. CONCLUSION These results highlight that additional targeted DNA NGS in chemotherapy-resistant translocation-associated sarcomas may reveal actionable oncogenic drivers occurring as secondary genetic events during disease progression.

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Surface Texturing Design to Enhance Echogenicity of Biopsy Needles During Endoscopic Ultrasound Imaging

Cited by 2 publications

References 22 publications

Anatomically realistic aortic dissection simulator as a potential training tool for point-of-care ultrasound

Anatomically realistic aortic dissection simulator as a potential training tool for point-of-care ultrasound

Modeling Extraordinary Response Through Targeting Secondary Alterations in Fusion-Associated Sarcoma

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