Surfactant administration prior to one lung ventilation: Physiological and inflammatory correlates in a piglet model

Bhatia, Rahul; Shaffer, Thomas H.; Hossain, Jobayer; Fisher, Alicia Olivant; Horner, Liana M.; Rodríguez, Maria E.; Penfil, Scott; Theroux, Mary C.

doi:10.1002/ppul.21485

Cited by 10 publications

(6 citation statements)

References 47 publications

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“…5 ). This process then releases RIG-I autorepression and allows RIG-I to undergo ATP hydrolysis and form signaling-active homo-oligomers within the RIG-I translocon that facilitates MAM targeting and interaction with MAVS for innate immune signaling ( Liu et al, 2012 , Bhatia et al, 2011 ). During viral infection, RIG-I expression levels are increased in response to IRF3 activation and IFN signaling, such that newly-synthesized RIG-I may have a lower threshold for activation due to having lower acetylation levels.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

et al. 2016

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Retinoic acid inducible gene-I (RIG-I) is a cytosolic pathogen recognition receptor that initiates the immune response against many RNA viruses. Upon RNA ligand binding, RIG-I undergoes a conformational change facilitating its homo-oligomerization and activation that results in its translocation from the cytosol to intracellular membranes to bind its signaling adaptor protein, mitochondrial antiviral-signaling protein (MAVS). Here we show that RIG-I activation is regulated by reversible acetylation. Acetyl-mimetic mutants of RIG-I do not form virus-induced homo-oligomers, revealing that acetyl-lysine residues of the RIG-I repressor domain prevent assembly to active homo-oligomers. During acute infection, deacetylation of RIG-I promotes its oligomerization upon ligand binding. We identify histone deacetylase 6 (HDAC6) as the deacetylase that promotes RIG-I activation and innate antiviral immunity to recognize and restrict RNA virus infection.

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Section: Discussionmentioning

confidence: 99%

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

et al. 2016

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“…Pulmonary function (PF) testing and WOB indices are vital tools in the diagnosis of many pediatric respiratory diseases, as well as guiding pulmonary therapy [1,5,[9][10][11]. These tests and indices are currently available only for patients on ventilators.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary function (PF) testing is a vital tool in the diagnosis and management of these pediatric respiratory diseases. Respiratory inductance plethysmography (RIP) and pneumotachography (PT) have been developed to analyze PF and tidal breathing in patients who are minimally cooperative because of their age or disease severity [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

pneuRIPTM: A Novel Respiratory Inductance Plethysmography Monitor

Rahman

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et al. 2017

Journal of Medical Devices

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Objective pulmonary function (PF) evaluation is essential for the diagnosis, monitoring, and management of many pediatric respiratory diseases as seen in the emergency room, intensive care, and outpatient settings. In this paper, the development and testing of a new noninvasive PF instrument, pneuRIP TM , which utilizes respiratory inductance plethysmography (RIP) are discussed. The pneuRIP TM hardware includes a small circuit board that connects to the RIP bands and measures and wirelessly transmits the band inductance data to any designated wirelessly connected tablet. The software provides indices of respiratory work presented instantaneously in a user-friendly graphical user interface on the tablet. The system was tested with ten normal children and compared with an existing system, Respitrace (Sensormedics, Yorba Linda, CA), under normal and loaded breathing conditions. Under normal breathing, the percentage differences between the two systems were 2.9% for labored breathing index (LBI), 31.8% for phase angle (U), 4.8% for percentage rib cage (RC%), and 26.7% for respiratory rate (BPM). Under loaded breathing, the percentage differences between the two systems were 1.6% for LBI, 4.1% for U, 8.5% for RC%, and 52.7% for BPM. For LBI, U, and RC%, the two systems were in general agreement. For BPM the pneuRIP TM is shown to be more accurate than the respitrace when compared to manually counting the breaths: 13.2% versus 36.4% accuracy for normal breathing and 16.9% versus 60.7% accuracy for breathing under load, respectively.

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“…Slinger et al (19) using regression analysis, found the side of operation to be one of the important factors in predicting hypoxemia during OLV. Therefore, right-OLV is safer than left-OLV when oxygenation is concerned, numerous researchers select right-OLV in their studies (20,21).…”

Section: Discussionmentioning

confidence: 99%

A novel method for right one-lung ventilation modeling in rabbits

Bian

et al. 2016

Experimental and Therapeutic Medicine

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There is no standard method by which to establish a right one-lung ventilation (OLV) model in rabbits. In the present study, a novel method is proposed to compare with two other methods. After 0.5 h of baseline two-lung ventilation (TLV), 40 rabbits were randomly divided into sham group (TLV for 3 h as a contrast) and three right-OLV groups (right OLV for 3 h with different methods): Deep intubation group, clamp group and blocker group (deeply intubate the self-made bronchial blocker into the left main bronchus, the novel method). These three methods were compared using a number of variables: Circulation by heart rate (HR), mean arterial pressure (MAP); oxygenation by arterial blood gas analysis; airway pressure; lung injury by histopathology; and time, blood loss, success rate of modeling. Following OLV, compared with the sham group, arterial partial pressure of oxygen and arterial hemoglobin oxygen saturation decreased, peak pressure increased and lung injury scores were higher in three OLV groups at 3 h of OLV. All these indexes showed no differences between the three OLV groups. During right-OLV modeling, less time was spent in the blocker group (6±2 min), compared with the other two OLV groups (13±4 min in deep intubation group, P<0.05; 33±9 min in clamp group, P<0.001); more blood loss was observed in clamp group (11.7±2.8 ml), compared with the other two OLV groups (2.3±0.5 ml in deep intubation group, P<0.001; 2.1±0.6 ml in blocker group, P<0.001). The first-time and final success rate of modeling showed no differences among the three OLV groups. Deep intubation of the self-made bronchial blocker into the left main bronchus is an easy, effective and reliable method to establish a right-OLV model in rabbits.

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Surfactant administration prior to one lung ventilation: Physiological and inflammatory correlates in a piglet model

Cited by 10 publications

References 47 publications

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

pneuRIPTM: A Novel Respiratory Inductance Plethysmography Monitor

A novel method for right one-lung ventilation modeling in rabbits

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