Surfactant bioconcentration - a critical review

Tolls, Johannes; Kloepper-Sams, Pamela J.; Sijm, Dick T.H.M.

doi:10.1016/0045-6535(94)90040-x

Cited by 98 publications

(94 citation statements)

References 43 publications

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“…As expected, empirical BCFs exhibit a positive relationship with both indicators of hydrophobicity [12,37]. Although deriving regression-based equations to describe the relationship between log BCF and hydrophobicity can be successful, it is also apparent that a substantial portion of the variability in empirical BCFs cannot be explained without introducing additional parameters, most importantly to represent susceptibility to biotransformation [55,56].…”

Section: Relationship Between Empirical Bcf and Hydrophobicitysupporting

confidence: 55%

“…Uptake and elimination rate constants measured for a few anionic surfactants, substituted phenols, and carboxylic acids and correlations with K OW,N suggest that hydrophobicity plays a key role in the uptake and elimination of IOCs [37][38][39][40]. General considerations for estimating E W for IOCs include the following: mass transfer of the neutral form of the IOC; (2) mass transfer of the charged form of the IOC (alone or in association with a counter-ion); (3) the degree of ionization in the aqueous phases (pH-driven); and (4) the rate of re-equilibration between the neutral and charged forms.…”

Section: Absorptionmentioning

confidence: 98%

“…The relevance of this pathway for chemical absorption efficiency at the gills is unclear. However, empirical data on the bioconcentration and tissue distribution of quaternary amine surfactants (e.g., hexadecylpyridinium, CAS 140-72-7) [37,48] seem to confirm that gill membranes are permeable to organic cations (alone or as an ion pair).…”

Section: Absorptionmentioning

confidence: 99%

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Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

Armitage

Arnot

Wania

et al. 2012

Enviro Toxic and Chemistry

160

241

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Abstract-A mechanistic mass balance bioconcentration model is developed and parameterized for ionogenic organic chemicals (IOCs) in fish and evaluated against a compilation of empirical bioconcentration factors (BCFs). The model is subsequently applied to a set of perfluoroalkyl acids. Key aspects of model development include revised methods to estimate the chemical absorption efficiency of IOCs at the respiratory surface (E W ) and the use of distribution ratios to characterize the overall sorption capacity of the organism. Membranewater distribution ratios (D MW ) are used to characterize sorption to phospholipids instead of only considering the octanol-water distribution ratio (D OW ). Modeled BCFs are well correlated with the observations (e.g., r 2 ¼ 0.68 and 0.75 for organic acids and bases, respectively) and accurate to within a factor of three on average. Model prediction errors appear to be largely the result of uncertainties in the biotransformation rate constant (k M ) estimates and the generic approaches for estimating sorption capacity (e.g., D MW ). Model performance for the set of perfluoroalkyl acids considered is highly dependent on the input parameters describing hydrophobicity (i.e., log K OW of the neutral form). The model applications broadly support the hypothesis that phospholipids contribute substantially to the sorption capacity of fish, particularly for compounds that exhibit a high degree of ionization at biologically relevant pH. Additional empirical data on biotransformation and sorption to phospholipids and subsequent incorporation into property estimation approaches (e.g., k M , D MW ) are priorities with respect to improving model performance. Environ. Toxicol. Chem. 2013;32:115-128. # 2012 SETAC

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Section: Relationship Between Empirical Bcf and Hydrophobicitysupporting

confidence: 55%

Section: Absorptionmentioning

confidence: 98%

See 1 more Smart Citation

Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

Armitage

Arnot

Wania

et al. 2012

Enviro Toxic and Chemistry

160

241

View full text Add to dashboard Cite

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“…Prominent among the alkylphenols, 4-nonylphenol (NP) enters the aquatic environment as a degradation product of nonylphenol ethoxylates (NPEO) used as nonionic surfactants in a variety of industrial and agricultural processes and as cleaning agents (Tolls et al, 1994). Field surveys have revealed that nonylphenols are distributed at low mg/L levels in the aquatic environment (Tsuda et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Comparison of ethinylestradiol and nonylphenol effects on reproduction of Chinese rare minnows (Gobiocypris rarus)

Zha

Sun

Spear

et al. 2008

Ecotoxicology and Environmental Safety

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Breeding pairs of rare minnows were exposed to 5, 10, 20 mg/L 4-nonylphenol (NP) or 4 ng/L 17a-ethinylestradiol (EE 2 ) for 21 days. Among reproductive parameters investigated, fecundity, fertility, and laying interval were significantly affected by 4 ng/L EE 2 , but were not affected at any exposure level of NP. These effects coincided with male feminization, ova-testis, increased plasma VTG in both males and females as well as the accumulation of eosinophilic material in kidneys and livers. Histopathologic evaluation revealed severe kidney lesions in both EE 2 and NP-exposed fish. The bioassay succeeded in demonstrating that EE 2 was several orders of magnitude more potent than the industrial chemical NP. The rare minnow was more sensitive to EE 2 than medaka, but comparable to zebrafish in terms of sensitivity. The results of the present investigation indicated that a short-term reproductive bioassay is feasible using the Chinese rare minnow as the test species. r

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“…(Gibbs et al, 1988;Jobling et al, 1996). 노닐페놀에 장기간 ( 노닐페놀은 생물체 내에서 암컷의 특징을 유발하는 물질로 알려져 있다 (Tolls et al, 1994;Ackermann et al, 2002).…”

Section: 소화선에서 지방갈색소의 분포비율을 알아보기 위해unclassified

Change of Reproductive and Histological Biomarkers of Ruditapes philippinarum (Bivalvia: Veneridae) Exposed to Nonylphenol

Park¹,

Lee²

2011

The Korean Journal of Malacology

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This study was investigated to find out the change of reproductive and histological biomarkers of Ruditapes philippinarum exposed to nonylphenol (NP). Experimental period was 16 weeks. Experimental groups were composed of one control condition and three NP exposure conditions (0.05, 0.1, 0.2 mg NP L -1 ). Gonad index was higher in exposure group than control in female and higher in control than exposure group in male. Intersexuality in the NP exposure group was 14.56% with male exhibiting higher ratio than female. Histological analysis of organ system illustrated expansion of hemolymph sinus, loss of striated border of inner epidermis and degeneration of mucous cell in the mantle. In the gill partially disappearance of frontal and lateral cilia, degeneration of mucous cell were observed. Also, hyperplasia of epithelium and disappearance of striated border were observed in the foot. As the concentration of NP increased, the accumulation of lipofuscin increased in the digestive gland. The results of this study suggest that NP induces reduction of survival rate, histopathology and intersex of R. philippinarum. Furthermore, it is indentified that NP functions as an estrogenic effector on the reproduction of R. philippinarum.

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Surfactant bioconcentration - a critical review

Cited by 98 publications

References 43 publications

Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish

Comparison of ethinylestradiol and nonylphenol effects on reproduction of Chinese rare minnows (Gobiocypris rarus)

Change of Reproductive and Histological Biomarkers of Ruditapes philippinarum (Bivalvia: Veneridae) Exposed to Nonylphenol

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