Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique

Al-Tameemi, Maha

doi:10.21123/bsj.2020.17.1.0057

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…To support the antibacterial activity of newly synthesized heterocyclic compounds, two types of proteins were used PDB-ID 4H2M (undecaprenyl diphosphate synthase) from E. coli and PDB -ID 3FYV (Descriptor Dihydrofolate reductase) from S. aureus are obtained from the Protein Data Bank (www.pdb.org). The synthesized compounds displayed interactions with the binding affinities with target proteins in emulation via the PyRx program 26,27…”

Section: In Silico Studiesmentioning

confidence: 99%

“…The molecular docking was performed by applying the blind docking mode of the PyRx software [20][21][22][23] , which is an important tool for gaining an understanding of the binding interactions between a ligand (prepared compound) and target receptors (mainly, a protein) [24][25][26] . In order to predict the inhibition of the target proteins corresponding to bacteria as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives

Sager,

Abaies,

Katoof

2024

Baghdad Sci.J

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In the field of molecular simulations, molecular docking is a method that can determine the optimal and preferred orientation of a certain molecule related to another when they are coupled to create a stable complex. The strength of the association, or binding affinity, between two molecules can be predicted using knowledge of their preferred orientation. In this study, a series of prepared compounds were evaluated for their binding modes, potential interactions, and target binding locations. Some derivatives 1,3-oxazepane, and 1,3-benzoxazepine were prepared from three Schiff bases compounds (1S-3S). The compounds (1S-3S) were reacted with succinic anhydride and phthalic anhydride to obtain derivatives of 1,3- oxazepane and 1,3-benzoxazepine (1B-3C). The characterization of prepared compounds was achieved by methods of elemental analysis, FT-IR, 1H, and 13C-NMR spectral analysis. The antibacterial activity of the compounds (1B-3C) was recorded against some isolated bacteria including gram-negative (Staphylococcus aureus), and gram-positive (E.coli) in parallel with Amoxicillin as a regular drug. Compounds (1B-3C) exhibited good values as antibacterial spreading from middling to perfect against the bacteria strains. Moreover, the antioxidant activity of the synthesized compounds (1B-3C) was evaluated using 2,2-diphenyl-1-picrylhydrazyl. The results showed that compounds have the highest values as radical scavenging.

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Section: In Silico Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives

Sager,

Abaies,

Katoof

2024

Baghdad Sci.J

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“…The physicochemical properties of Metoclopramide Analytical methods previously published for the quantification of metoclopramide in bulk [13,14,15], pharmaceutical dosage forms [16,17,18], and biological fluids were scanned in the literatüre [19,20,21]. Spectrophotometric [22,23,24], high-performance liquid chromatographic [25,26,27], and liquid chromatographic coupled with tandem mass spectrometry (LC-MS/MS) [28] methods were reported for determination of metoclopramide in pharmaceutical dosage forms and biological fluids were developed.…”

Section: Tablementioning

confidence: 99%

A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods

DEMİR,

Bulduk,

DARWISH

et al. 2023

Preprint

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Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a combination of ethanol and formic acid solution (pH 2.0; 30:70 v/v). Isocratic elution was applied and the flow rate was set at 1.0 mL min− 1. Metoclopramide was detected at 273 nm. The methods performed were economical, rapid, environmentally friendly, and simple, providing metoclopramide analysis within 5 minutes. The methods have been successfully applied in pharmaceutical products without matrix interference. The results of the application of the developed methods to pharmaceutical products were statistically compared and no significant difference was observed between the methods. In addition, the greenness assessment of the developed methods was performed using AGREE software. The developed methods are proposed as excellent environmental and operator-friendly alternatives for the quantification of metoclopramide in pharmaceutical formulations.

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“…Analytical methods previously published for the quantification of metoclopramide in bulk 13 – 15 , pharmaceutical dosage forms 16 – 18 , and biological fluids were scanned in the literatüre 19 – 21 . Spectrophotometric 22 – 24 , high-performance liquid chromatographic 25 – 27 , and liquid chromatographic coupled with tandem mass spectrometry (LC–MS/MS) 28 methods were reported for determination of metoclopramide in pharmaceutical dosage forms and biological fluids were developed.…”

Section: Introductionmentioning

confidence: 99%

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

Demir,

Bulduk,

Darwısh

et al. 2024

Sci Rep

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Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a combination of ethanol and formic acid solution (pH 2.0; 30:70 v/v). Isocratic elution was applied and the flow rate was set at 1.0 mL min−1. Metoclopramide was detected at 273 nm. The methods performed were economical, rapid, environmentally friendly, and simple, providing metoclopramide analysis within 5 min. The methods have been successfully applied in pharmaceutical products without matrix interference. The results of the application of the developed methods to pharmaceutical products were statistically compared and no significant difference was observed between the methods. In addition, the greenness assessment of the developed methods was performed using AGREE software. Our developed methods, based on the use of solvents such as ethanol and water, are proposed as a more environmentally and analyst-friendly option for the quantification of metoclopramide in pharmaceutical products than other methods currently in use.

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Surfactant Cloud Point Extraction as a Procedure of Preconcentrating for Metoclopramide Determination Using Spectro Analytical Technique

Cited by 7 publications

References 1 publication

Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives

Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives

A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods

A green approach for metoclopramide quantification in pharmaceutical products: new HPLC and spectrophotometric methods

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