Surge Plateletapheresis

Elias, M. K.; Pol, H.; Weggemans, M.; Maas, A.; Das, P. C.; Sibinga, C. Th. Smit

doi:10.1007/978-1-4613-2089-0_16

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Similar changes were also observed by Sirchia et al [7]; but there was no significant difference in the hypotonic shock response before or after filtration. The in vitro function and integrity of the filtered apheresis plate lets were not affected as tested by hypotonic shock response, change in morphologic score or electron-micro scopic morphology [25]. In vivo increments and function of the filtered platelets have been shown to function normally in vivo [7].…”

Section: Methodsmentioning

confidence: 89%

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Comparison of Three Different Methods Used in the Preparation of Leukocyte-Poor Platelet Concentrates

Koerner¹,

Kubanek²

1987

Vox Sanguinis

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We compared three methods for preparing leukocyte-poor platelet concentrates from random donors: the centrifugation procedure 400 g/6 min, the filtration by Immugard TFIG 500 Y and the Cutter Leukotrap platelet pooling system. The most efficient method with regard to removal of leukocytes and platelet yield could be obtained by filtration through the Immugard filter. Platelet loss was less than 10% and the residual leukocyte count was lower than 10 x 10^6.

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Section: Methodsmentioning

confidence: 89%

“…The removal of contaminating leukocytes from apheresis-derived platelets has been reported [25]. The platelets were harvested by an apheresis machine using the surge technique.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Three Different Methods Used in the Preparation of Leukocyte-Poor Platelet Concentrates

Koerner¹,

Kubanek²

1987

Vox Sanguinis

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Preparation and storage of “leukocyte‐depleted single donor” platelet concentrate: A step forward in effective haemotherapy

Elias

Wolf

Blom

et al. 1991

J of Clinical Apheresis

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"Leukocyte-depleted" platelet concentrates (LD-SDPC) were prepared by cotton-wool and by polyester filtration of "leukocyte-poor" PC collected by the elutriation technique. The storage characteristics of LD-SDPC were comparable to those of the filtered pools of multiple donor platelet concentrates (LD-MDPC). However, LD-SDPC were less activated and less damaged than LD-MDPC over a 7-day storage period, as evidenced by beta-thromboglobin percent release and lactic dehydrogenase percent leakage in both products. LD-SDPC were prophylactically transfused to 12 thrombocytopenic patients; the mean bleeding time was shortened from 12 min 20 sec to 4 min 39 sec. Corrected count increment (CCI) was 22.8 at 1 hr and 14.1 at 24 hr compared to 15.5 and 10.0, respectively, with standard PCs.

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Evaluation of elutriated single donor platelets collected and stored in a closed system

Elias

Blom

Rijskamp

et al. 1992

J of Clinical Apheresis

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Single donor platelets (SDPC) were collected by the elutriation technique in a closed-system integrated with large storage containers. Seven runs of SDPC were stored in a 1.5 liter polyvinyl-chloride trimellitate (PVC-TOTM) storage container, making the ratio of platelet concentrate volume to container volume 1:4.5. An equal volume of pooled multiple donor platelet concentrates (MDPC) was stored in parallel under the same conditions. All haematological data were comparable for both products, except for the degree of leukocyte contamination (5-fold increase in the pool). Under these conditions, the functional, morphological, and metabolic characteristics of elutriated platelets throughout 7-day storage were superior to those of pooled platelets. Although the platelet count was not significantly different in both types of concentrates, the mean pH of pooled MDPC fell to 6.0 on day 5 of storage. Leukocytes were shown to contribute to this pH fall. The extent of cell damage, however, as evidenced by LDH leakage (42.7 LDH units/10(11) platelets/day by differential centrifugation, compared to 5.3 units by elutriation) could not be explained solely on the basis of the leukocyte effect. This indicated that the processing method itself influences the platelet quality. By increasing the surface/volume ratio of SDPC, the initial pH of 7.1 was well maintained throughout storage, platelet metabolic rate was slowed, and the function and ultrastructure improved significantly.

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Surge Plateletapheresis

Cited by 4 publications

References 12 publications

Comparison of Three Different Methods Used in the Preparation of Leukocyte-Poor Platelet Concentrates

Comparison of Three Different Methods Used in the Preparation of Leukocyte-Poor Platelet Concentrates

Preparation and storage of “leukocyte‐depleted single donor” platelet concentrate: A step forward in effective haemotherapy

Evaluation of elutriated single donor platelets collected and stored in a closed system

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