Surgery alone provides long-term survival rates comparable to those of surgery plus postoperative radiotherapy for patients with adenoid cystic carcinoma of the palate

Li, Qun; Xu, Tao; Gao, Jian-ming; Ye, Weijun; Gu, Mo-Fa; Hu, Weixin; Wang, Fang

doi:10.1016/j.oraloncology.2010.12.005

Cited by 13 publications

(16 citation statements)

References 12 publications

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“…This study method was also similar to that of Schmidt et al (2014), who investigated the outcomes of nodal metastatic cutaneous squamous carcinoma of the head and neck treated in a regional center. In our cases, only 4 patients experienced local failure with an incidence of 8.5%, which was much lower than the percentage (21%e77%) reported by prior investigators (Li et al, 2011;Agarwal et al, 2008;Shen et al, 2012;da Cruz et al, 2006;Bianchi et al, 2008). However, this rate was higher than the local recurrence ratio of 3.3% in the study of early stage ACC of the major salivary gland (Bhayani et al, 2012).…”

Section: Discussioncontrasting

confidence: 68%

“…However, this rate was higher than the local recurrence ratio of 3.3% in the study of early stage ACC of the major salivary gland (Bhayani et al, 2012). The overall DM rate was 36.1% in our patients with predominant site of lung, and it was much higher than the average incidence of about 15%e20% as demonstrated by previous works (Li et al, 2011;Agarwal et al, 2008;Van et al, 2013;Amit et al, 2014b;Bianchi et al, 2008;Maciejewski et al, 2002). ACC patients with LN involvement had higher DM rates (40%) than those without LN invasion (27%) (Amit et al, 2014a).…”

Section: Discussioncontrasting

confidence: 51%

“…Positive LN has been associated with poorer survival rate compared with the rates in patients without lymphatic disease (Amit et al, 2014a,b,c;Min et al, 2012). Predictive factors for survival, such as postoperative radiotherapy, tumor site, TNM stage, histological subtype, and surgical margin, have been extensively discussed in general ACC patients (Li et al, 2011;Agarwal et al, 2008;Van et al, 2013). To our knowledge, there is no study concerning the prognostic analysis on ACC patients with LN metastasis (ACC-LNM) thus far.…”

Section: Introductionmentioning

confidence: 99%

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Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Liu

Fang

Dai

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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Section: Discussioncontrasting

confidence: 68%

Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Liu

Fang

Dai

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…ACC of the salivary gland is associated with an increased risk of a positive margin following resection, compared to adenocarcinoma, and is therefore associated with poor prognosis [26]. Although one study reported that surgery alone provided long-term survival rates comparable to those of surgery plus radiotherapy, others found that radiotherapy was effective in cases involving positive margins [27][28][29]. In our study, a patient receiving postoperative CCRT achieved CR, followed by systemic relapse but not local recurrence.…”

Section: Discussionmentioning

confidence: 46%

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Keam

Ock

et al. 2021

Korean J Intern Med

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Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.

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“…ACC is known for its prolonged clinical course, perineural invasion, multiple recurrence rates and delayed onset of distant metastasis. Lymph node metastases are unusual; hematogenous spread, often to the lungs is quite characteristic, metastasis to kidney being extremely rare [6][7][8]. Here we present a case of adenoid cystic carcinoma of the right buccal mucosa that was surgically excised and healed uneventfully.…”

Section: Introductionmentioning

confidence: 92%

Adenoid Cystic Carcinoma of Buccal Mucosa: A Rare Case Report

Garg

Roy

Khanna

et al. 2015

Indian J Otolaryngol Head Neck Surg

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Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Among intra oral adenoid cystic carcinoma, buccal mucosa is among the rarest sites. We report a case of adenoid cystic of buccal mucosa in a 40-year old female. We have discussed the clinical features, histopathology, diagnosis and treatment along with a brief review of the relevant literature. Although the buccal mucosa is an uncommon site for adenoid cystic carcinoma, the relatively indolent growth pattern of this case and its location which is rather atypical for this type of salivary gland malignancy primarily warrants the necessity behind reporting of this case. Secondly, adenoid cystic carcinoma should be considered in the differential diagnosis of mass of buccal mucosa. It is important to identify such cases rather early and surgical removal with adequate margins is the treatment of choice.

show abstract

Surgery alone provides long-term survival rates comparable to those of surgery plus postoperative radiotherapy for patients with adenoid cystic carcinoma of the palate

Cited by 13 publications

References 12 publications

Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma

Adenoid Cystic Carcinoma of Buccal Mucosa: A Rare Case Report

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