Surgery for “Long-term epilepsy associated tumors (LEATs)”: Seizure outcome and its predictors

Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

“…2,[4][5][6][7][9][10][11][12][13] In line with literature data, complete seizure control was achieved in 89.7% of patients. 2,[4][5][6][7][9][10][11][12][13] In line with literature data, complete seizure control was achieved in 89.7% of patients.…”

“…11,12 Among the three variables that independently predict seizure outcome at multivariate analysis, age at surgery is largely the most significant, and the probability of unfavorable outcome grows by 4% for every waited year. 11,12 Among the three variables that independently predict seizure outcome at multivariate analysis, age at surgery is largely the most significant, and the probability of unfavorable outcome grows by 4% for every waited year.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] For this group of tumors the acronym "LEATs" (longterm epilepsy associated tumors) was proposed by Luyken et al 1 By definition, "long term" means causing drug-resistant seizures for 2 years or more. [1][2][3][4][5][6][7][8][9][10][11][12][13] For this group of tumors the acronym "LEATs" (longterm epilepsy associated tumors) was proposed by Luyken et al 1 By definition, "long term" means causing drug-resistant seizures for 2 years or more.…”

“…18 If uncontrolled, tumor-related epilepsy significantly affects patients' quality of life, causes cognitive deterioration, and may result in significant morbidity. 2,[9][10][11]13,20 Currently, the definition of drugresistance applies to "failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom," 21 and it may be difficult to assess this criterion in <2 years. 2,[9][10][11]13,20 Currently, the definition of drugresistance applies to "failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom," 21 and it may be difficult to assess this criterion in <2 years.…”

“…Low grade epilepsy associated neuroepithelial tumors (LEATs) encompass a large spectrum of low-grade glial (LGG) tumor or glioneuronal tumor (GNT) frequently encountered in epilepsy surgery practice, particularly in children and young adults. [1][2][3][4][5][6][7][8][9][10][11][12][13] For this group of tumors the acronym "LEATs" (longterm epilepsy associated tumors) was proposed by Luyken et al 1 By definition, "long term" means causing drug-resistant seizures for 2 years or more.…”